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Adult Glial Cell Proliferation and Neurogenesis
The nomenclature of stem and progenitor cells is reviewed. In the adult body, only glial cells and not neurons can proliferate. The glial cell with...
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Effect of elevated temperature and hydrocortisone addition on the proliferation of fibroblasts
Hyperthermia along with hydrocortisone (HC) are proven teratogens that can negatively influence embryo development during early pregnancy....
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ARF6 promotes hepatocellular carcinoma proliferation through activating STAT3 signaling
BackgroundHepatocellular Carcinoma (HCC) possesses the high mortality in cancers worldwide. Nevertheless, the concrete mechanism underlying HCC...
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Metformin suppresses proliferation and glycolysis of gastric cancer by modulating ADAMTS12
BackgroundGastric cancer (GC) is a common malignancy with its morbidity increasing worldwide. Hence, it is imperative to develop effective...
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The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis
Natural killer (NK) cells are predominant innate lymphocytes that initiate the early immune response during infection. NK cells undergo a metabolic...
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Glucocorticoid Receptor Down-Regulation Affects Neural Stem Cell Proliferation and Hippocampal Neurogenesis
Dysregulation of the hypothalamic–pituitary–adrenal axis and abnormalities in the glucocorticoid receptor (GR) have been linked to major depressive...
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Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms
A genetic system, ProTracer, has been recently developed to record cell proliferation in vivo. However, the ProTracer is initiated by an infrequently...
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The search for CDK4/6 inhibitor biomarkers has been hampered by inappropriate proliferation assays
CDK4/6 inhibitors are effective at treating advanced HR+ /HER2- breast cancer, however biomarkers that can predict response are urgently needed. We...
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Orientin regulates the proliferation and migration of hepatocellular carcinoma cells
Orientin is a flavone isolated from medicinal plants used in traditional Chinese medicine (TCM) that suppresses the growth of cancer cells in vitro....
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TRIM8 Promotes Proliferation, Invasion, and Migration of Cervical Cancer Cells by Ubiquitinating and Degrading SOCS1
Cervical cancer (CC) is a malignant tumor primarily caused by the persistent infection with high-risk strains of human papillomavirus. This study...
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microRNA-622 upregulates cell cycle process by targeting FOLR2 to promote CRC proliferation
BackgroundEpigenetic alterations contribute greatly to the development and progression of colorectal cancer, and effect of aberrant miR-622...
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Cancer as a Disease of Cell Proliferation
Evolutionary dynamics relates the growth and development of tumours to changes in rates of cell proliferation and cell death, and to their mutation...
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iAstrocytes do not restrain T cell proliferation in vitro
The cross-talk between T cells and astrocytes occurring under physiological and, even more, neuroinflammatory conditions may profoundly impact the...
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RORα inhibits gastric cancer proliferation through attenuating G6PD and PFKFB3 induced glycolytic activity
BackgroundGlycolysis is critical for harvesting abundant energy to maintain the tumor microenvironment in malignant tumors. Retinoic acid-related...
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Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway
Hepatocellular carcinoma (HCC) is a highly vascularized tumor, one of the most common and lethal cancer-related tumor deaths worldwide, with cell...
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Effect of Proinflammatory S100A9 Protein on Migration and Proliferation of Microglial Cells
Alzheimer’s disease (AD) is a multifactorial disease affecting aging population worldwide. Neuroinflammation became a focus of research as one of the...
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Yap/Taz activity is associated with increased expression of phosphoglycerate dehydrogenase that supports myoblast proliferation
In skeletal muscle, the Hippo effector Yap promotes satellite cell, myoblast, and rhabdomyoblast proliferation but prevents myogenic differentiation...
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STEAP3 promotes colon cancer cell proliferation and migration via regulating histone acetylation
Colorectal cancer (CRC) is the third most prevalent diagnosed cancer in men and second most prevalent cancer in women. H3K27ac alterations are more...
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Targeting MYH9 represses USP14-mediated NAP1L1 deubiquitination and cell proliferation in glioma
Myosin heavy chain 9 (MYH9) plays an important role in a number of diseases. Nevertheless, the function of MYH9 in glioma is unclear. The present...
