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Tiagabine and zonisamide differentially regulate the glial properties in an astrocyte-microglia co-culture model of inflammation
Due to the role of astrocytes and microglia in the pathophysiology of epilepsy and limited studies of antiseizure medication (ASM) effects on glial...
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Glutamine Maintains Satellite Glial Cells Growth and Survival in Culture
Satellite glial cells (SGCs) tightly surround neurons and modulate sensory transmission in dorsal root ganglion (DRG). At present, the biological...
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Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease
Communication between glial cells has a profound impact on the pathophysiology of Alzheimer’s disease (AD). We reveal here that reactive astrocytes...
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Culture and Phenoty** of Glial Cell Cultures, Gliospheres , and Neurospheres
Cell cultures constitute an important tool for research as a way to reproduce pathological processes in a controlled system. However, the culture of...
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Evolution of glial cells: a non-bilaterian perspective
Nervous systems of bilaterian animals generally consist of two cell types: neurons and glial cells. Despite accumulating data about the many...
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β-adrenergic signaling triggers enteric glial reactivity and acute enteric gliosis during surgery
BackgroundEnteric glia contribute to the pathophysiology of various intestinal immune-driven diseases, such as postoperative ileus (POI), a motility...
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TUNEL-n-DIFL Method for Detection and Estimation of Apoptosis Specifically in Neurons and Glial Cells in Mixed Culture and Animal Models of Central Nervous System Diseases and Injuries
Detection of merely apoptosis does not reveal the type of central nervous system (CNS) cells that are dying in the CNS diseases and injuries. In situ...
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The Node of Ranvier as an Interface for Axo-Glial Interactions: Perturbation of Axo-Glial Interactions in Various Neurological Disorders
The action potential conduction along the axon is highly dependent on the healthy interactions between the axon and myelin-producing glial cells....
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Isolation and Culture of Mouse Primary Microglia and Oligodendrocyte Precursor Cells
Microglia and oligodendrocyte precursor cells (OPCs) are critical glia subsets in the central nervous system (CNS) and are actively engaged in a body...
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Isolation and Differentiation of Neurons and Glial Cells from Olfactory Epithelium in Living Subjects
The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently,...
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Cell-free oxidized hemoglobin drives reactive oxygen species production and pro-inflammation in an immature primary rat mixed glial cell culture
BackgroundGerminal matrix intraventricular hemorrhage (GM-IVH) is associated with deposition of redox active cell-free hemoglobin (Hb), derived from...
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Cleaved caspase-3 is present in the majority of glial cells in the intact rat spinal cord during postnatal life
Cell death is an essential process that occurs during the development of the central nervous system. Despite the availability of a wide range of...
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The Structure and Function of Glial Networks: Beyond the Neuronal Connections
Glial cells, consisting of astrocytes, oligodendrocyte lineage cells, and microglia, account for >50% of the total number of cells in the mammalian...
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Association of Glial Activation and α-Synuclein Pathology in Parkinson’s Disease
The accumulation of pathological α-synuclein (α-syn) in the central nervous system and the progressive loss of dopaminergic neurons in the substantia...
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MiR-155-5p Aggravated Astrocyte Activation and Glial Scarring in a Spinal Cord Injury Model by Inhibiting Ndfip1 Expression and PTEN Nuclear Translocation
Central nervous injury and regeneration repair have always been a hot and difficult scientific questions in neuroscience, such as spinal cord injury...
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A Three-Dimensional Primary Cortical Culture System Compatible with Transgenic Disease Models, Virally Mediated Fluorescence, and Live Microscopy
In vitro cell culture models can offer high-resolution and high-throughput experimentation of cellular behaviors. However, in vitro culture...
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Enteric glial cells aggravate the intestinal epithelial barrier damage by secreting S100β under high-altitude conditions
Damage to the intestinal epithelial barrier (IEB) has been reported under high-altitude (HA) conditions and may be responsible for HA-associated...
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MiR-26b-3p Promotes Intestinal Motility Disorder by Targeting FZD10 to Inhibit GSK3β/β-Catenin Signaling and Induce Enteric Glial Cell Apoptosis
Enteric glial cells (EGCs) are the major component of the enteric nervous system and affect the pathophysiological process of intestinal motility...
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Glial-Neuronal Interaction in Synapses: A Possible Mechanism of the Pathophysiology of Bipolar Disorder
Bipolar disorder (BD) is a severe and chronic psychiatric disorder that affects approximately 1–4% of the world population and is characterized by...
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Synaptic pruning through glial synapse engulfment upon motor learning
Synaptic pruning is a fundamental process of neuronal circuit refinement in learning and memory. Accumulating evidence suggests that glia...
