Search
Search Results
-
Lipids and Secretory Vesicle Exocytosis
In recent years, the number of studies implicating lipids in the regulation of synaptic vesicle exocytosis has risen considerably. It has become...
-
Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein
Pathologic inclusions composed of α-synuclein called Lewy pathology are hallmarks of Parkinson’s Disease (PD). Dominant inherited mutations in...
-
Liprin-α proteins are master regulators of human presynapse assembly
The formation of mammalian synapses entails the precise alignment of presynaptic release sites with postsynaptic receptors but how nascent cell–cell...
-
Association of variants in the KIF1A gene with amyotrophic lateral sclerosis
BackgroundAmyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease that affects neurons in the central nervous...
-
Optogenetics at the presynapse
Optogenetic actuators enable highly precise spatiotemporal interrogation of biological processes at levels ranging from the subcellular to cells,...
-
Axonal Degeneration, Impaired Axonal Transport, and Synaptic Dysfunction in Motor Neuron Disorder
Motor neuron diseases (MNDs) are progressive disorders of the neurological system that have a strong effect on upper and lower motor neuron systems....
-
Extracellular Vesicle-Serpine-1 Affects Neural Progenitor Cell Mitochondrial Networks and Synaptic Density: Modulation by Amyloid Beta and HIV-1
Brain endothelial extracellular vesicles carrying amyloid beta (EV-Aβ) can be transferred to neural progenitor cells (NPCs) leading to NPC...
-
Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation
Understanding medium spiny neuron (MSN) physiology is essential to understand motor impairments in Parkinson’s disease (PD) given the architecture of...
-
Endoplasmic Reticulum in Metaplasticity: From Information Processing to Synaptic Proteostasis
The ER (endoplasmic reticulum) is a Ca 2+ reservoir and the unique protein-synthesizing machinery which is distributed throughout the neuron and...
-
The Effect of Sleep Deprivation and Subsequent Recovery Period on the Synaptic Proteome of Rat Cerebral Cortex
Sleep deprivation (SD) is commonplace in the modern way of life and has a substantial social, medical, and human cost. Sleep deprivation induces...
-
Specification and Development of GABAergic Interneurons
Of all cerebellar cells, the development of inhibitory interneurons is arguably least understood. The issue is further convoluted by the fact that...
-
Axonal Transport
Axons are long slender cylindrical projections of neurons that enable these cells to communicate directly with other cells in the body over long...
-
Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson’s disease
In addition to the well-known degeneration of midbrain dopaminergic neurons, enteric neurons can also be affected in neurodegenerative disorders such...
-
Transmitters and Peptides: Basic Principles
Signaling between cells plays an important role in all multicellular organisms, both in the nervous system as well as other tissues. Most...
-
The Brain as an Organ
Neurons are highly specialized for circuit activity. Their unique structure and function make them very vulnerable to small fluctuations in the...
-
Basic Properties of Biological Neurons and Synapses
In this chapter we shall make the case that in the study of brain function – from computational or clinical points of view – it is essential to take...
-
Drugs Acting on Central Nervous System
Central nervous system is the part of the body which is responsible for accepting, processing, and creating response against the external stimuli or...
-
Nutrition and Brain Neurotransmitters
Neurotransmitters are the chemical language with which different neurons communicate and with which the brain and the environment communicate with...
-
From Motor Neuron to Muscle—Studies by the School of E.E. Nikolsky
Abstract —The Kazan school of neurobiology, which originated in the 19th century, is famous for its outstanding teachers and students. One of the...
-
Cells of the Central Nervous System: An Overview of Their Structure and Function
The central nervous system is the last major organ system in the vertebrate body to yield its cellular structure, due to the complexity of its cells...