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Preclinical Mouse Model of Silicosis
Silicosis is an untreatable occupational lung disease caused by chronic inhalation of crystalline silica. Cyclical release and reuptake of silica...
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Preclinical Mouse Metastatic Model Established Through Induced Lung Metastases
Metastatic disease is the major cause of cancer death, and the lung is one of the most common sites of cancer metastases. To investigate systemic...
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Orthotopic MC-38 Allograft as a Robust Preclinical Model of Colorectal Carcinoma
Colorectal cancer (CRC) is a significant global health concern, requiring effective preclinical models for studying its development and testing...
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Expansion of platform physiologically-based pharmacokinetic model for monoclonal antibodies towards different preclinical species: cats, sheep, and dogs
Monoclonal antibodies (mAbs) are becoming an important therapeutic option in veterinary medicine, and understanding the pharmacokinetic (PK) of mAbs...
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Towards a platform quantitative systems pharmacology (QSP) model for preclinical to clinical translation of antibody drug conjugates (ADCs)
A next generation multiscale quantitative systems pharmacology (QSP) model for antibody drug conjugates (ADCs) is presented, for preclinical to...
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Genetically Engineered and Spontaneous Animal Model: Utilization in Preclinical Cancer Therapy Development
Comparative transcriptomics demonstrate that various animal cancer models share molecular signatures with human cancers. Preclinical evaluation with...
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Metastatic Melanoma: A Preclinical Model Standardization and Development of a Chitosan-Coated Nanoemulsion Containing Temozolomide to Treat Brain Metastasis
Melanoma is the most aggressive type of skin cancer. Brain metastasis is the worst scenario in metastatic melanoma and the treatment options for...
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Patient-Derived Xenografts: A Valuable Preclinical Model for Drug Development and Biomarker Discovery
Patient-derived xenografts (PDXs), established by implanting patient tumor cells into immunodeficient mice, offer a platform for faithfully...
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Characterization of preclinical Alzheimer’s disease model: spontaneous type 2 diabetic cynomolgus monkeys with systemic pro-inflammation, positive biomarkers and develo** AD-like pathology
BackgroundThe key to the prevention and treatment of Alzheimer’s disease (AD) is to be able to predict and diagnose AD at the preclinical or early...
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Preclinical Models of Meningioma
The management of clinically aggressive meningiomas remains challenging due to limited treatment options aside from surgical removal and...
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Available Preclinical Tools for Neuroblastoma
Neuroblastoma is the most predominant and deadly cancer in infants and in young children and contributes significantly to childhood cancer deaths....
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Inhibition of choline metabolism in an angioimmunoblastic T-cell lymphoma preclinical model reveals a new metabolic vulnerability as possible target for treatment
BackgroundAngioimmunoblastic T-cell lymphoma (AITL) is a malignancy with very poor survival outcome, in urgent need of more specific therapeutic...
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Preclinical Models of Retinitis Pigmentosa
Retinitis pigmentosa (RP) is the name for a group of phenotypically-related heritable retinal degenerative disorders. Many genes have been implicated...
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Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease
BackgroundRegulatory T cells (Tregs) play a neuroprotective role by suppressing microglia and macrophage-mediated inflammation and modulating...
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Antigen identification strategies and preclinical evaluation models for advancing tuberculosis vaccine development
In its myriad devastating forms, Tuberculosis (TB) has existed for centuries, and humanity is still affected by it. Mycobacterium tuberculosis ( M....
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Generation of Anti-HIV CAR-T Cells for Preclinical Research
The inability of people living with HIV (PLWH) to eradicate human immunodeficiency virus (HIV) infection is due in part to the inadequate...
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Towards a better preclinical cancer model – human immune aging in humanized mice
BackgroundPreclinical models are often used for cancer studies and evaluation of novel therapeutics. The relevance of these models has vastly...
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Viltolarsen: From Preclinical Studies to FDA Approval
Viltolarsen is a phosphorodiamidate morpholino antisense oligonucleotide (PMO) designed to skip exon 53 of the DMD gene for the treatment of Duchenne...
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Resurgence of syphilis: focusing on emerging clinical strategies and preclinical models
Syphilis, a sexually transmitted disease (STD) caused by Treponema pallidum ( T. pallidum ), has had a worldwide resurgence in recent years and remains...
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Preclinical models in head and neck squamous cell carcinoma
Head and neck cancer is the sixth most frequent cancer type. Drug resistance and toxicity are common challenges of the existing therapies, making the...
