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Preclinical Models of Meningioma
The management of clinically aggressive meningiomas remains challenging due to limited treatment options aside from surgical removal and...
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Preclinical Models of Retinitis Pigmentosa
Retinitis pigmentosa (RP) is the name for a group of phenotypically-related heritable retinal degenerative disorders. Many genes have been implicated...
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Available Preclinical Tools for Neuroblastoma
Neuroblastoma is the most predominant and deadly cancer in infants and in young children and contributes significantly to childhood cancer deaths....
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Antigen identification strategies and preclinical evaluation models for advancing tuberculosis vaccine development
In its myriad devastating forms, Tuberculosis (TB) has existed for centuries, and humanity is still affected by it. Mycobacterium tuberculosis ( M....
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Preclinical models in head and neck squamous cell carcinoma
Head and neck cancer is the sixth most frequent cancer type. Drug resistance and toxicity are common challenges of the existing therapies, making the...
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Preclinical Mouse Metastatic Model Established Through Induced Lung Metastases
Metastatic disease is the major cause of cancer death, and the lung is one of the most common sites of cancer metastases. To investigate systemic...
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Preclinical Mouse Model of Silicosis
Silicosis is an untreatable occupational lung disease caused by chronic inhalation of crystalline silica. Cyclical release and reuptake of silica...
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Viltolarsen: From Preclinical Studies to FDA Approval
Viltolarsen is a phosphorodiamidate morpholino antisense oligonucleotide (PMO) designed to skip exon 53 of the DMD gene for the treatment of Duchenne...
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Patient-derived tumor models: a suitable tool for preclinical studies on esophageal cancer
Esophageal cancer (EC) is the tenth most common cancer worldwide and has high morbidity and mortality. Its main subtypes include esophageal squamous...
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Resurgence of syphilis: focusing on emerging clinical strategies and preclinical models
Syphilis, a sexually transmitted disease (STD) caused by Treponema pallidum ( T. pallidum ), has had a worldwide resurgence in recent years and remains...
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Generation of Anti-HIV CAR-T Cells for Preclinical Research
The inability of people living with HIV (PLWH) to eradicate human immunodeficiency virus (HIV) infection is due in part to the inadequate...
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Quantitative Evaluation of Stance as a Sensitive Biomarker of Postural Ataxia Development in Preclinical SCA1 Mutation Carriers
The aim of this study was to determine the time between the first detection of postural control impairments and the evident manifestation of ataxia...
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Chronic Pain–Related Cognitive Deficits: Preclinical Insights into Molecular, Cellular, and Circuit Mechanisms
Cognitive impairment is a common comorbidity of chronic pain, significantly disrupting patients’ quality of life. Despite this comorbidity being...
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Preclinical Toxicity Studies
Preclinical toxicity studies involve testing the newly screened compounds to determine the safety of that compound in at least two different animal...
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Small cells – big issues: biological implications and preclinical advancements in small cell lung cancer
Current treatment guidelines refer to small cell lung cancer (SCLC), one of the deadliest human malignancies, as a homogeneous disease. Accordingly,...
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Advancing preclinical cancer models to assess clinically relevant outcomes
Cancer models are indispensable research tools for elucidating the mechanisms involved in tumor onset, progression and treatment resistance. They are...
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Orthotopic MC-38 Allograft as a Robust Preclinical Model of Colorectal Carcinoma
Colorectal cancer (CRC) is a significant global health concern, requiring effective preclinical models for studying its development and testing...
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A Retrospective Analysis of Preclinical and Clinical Pharmacokinetics from Administration of Long-Acting Aqueous Suspensions
Administration of long-acting injectable suspensions is an increasingly common approach to increasing patient compliance and improving therapeutic...
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Role of Modeling and Simulation in Preclinical and Clinical Long-Acting Injectable Drug Development
Innovations in the field of long-acting injectable drug development are increasingly being reported. More advanced in vitro and in vivo ...
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Preclinical Models in Colorectal Cancer Drug Discovery
Currently, colorectal cancer (CRC) remains one of the most common causes of cancer-related death worldwide despite advances in medical therapies of...