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Alzheimer’s pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome
BackgroundTraumatic encephalopathy syndrome (TES) is a clinical phenotype sensitive but non-specific to underlying chronic traumatic encephalopathy...
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A randomized, cross-over trial assessing effects of beverage sodium concentration on plasma sodium concentration and plasma volume during prolonged exercise in the heat
PurposeThis study assessed whether increasing sodium in a sports drink above that typical (~ 20 mmol L −1 ) affects plasma sodium and volume responses...
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Microfluidic Acoustic Method for High Yield Extraction of Cell-Free DNA in Low-Volume Plasma Samples
Cell-free DNA has many applications in clinical medicine, in particular in cancer diagnosis and cancer treatment monitoring. Microfluidic-based...
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Effects of ingestion of isomaltulose beverage on plasma volume and thermoregulatory responses during exercise in the heat
PurposeIsomaltulose is a low glycemic and insulinaemic carbohydrate increasingly used as an alternative sweetener in commercial beverages. While...
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The association between vitamin B12 and plasma homocysteine levels with episodic memory and the volume of memory related brain structures in middle-aged individuals: a retrospective correlational study
In previous studies, decreased vitamin B12 and increased plasma homocysteine levels were reported as risk factors for dementia. The aim of this study...
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Piezo1, the new actor in cell volume regulation
All animal cells control their volume through a complex set of mechanisms, both to counteract osmotic perturbations of the environment and to enable...
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Quantification of Endocannabinoids in Human Plasma
The determination of the concentration of endocannabinoids and related compounds in human plasma has become a matter of interest due to their...
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Gas Plasma Surface Modification for Biological Assays
Surface chemistry plays an important role in the adsorption and immobilization of enzymes and antibodies. Gas plasma technology performs surface...
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Water Balance and the Regulation of Plasma Osmolality
The kidney plays a key role in the regulation of plasma osmolality, which is directly related to the maintenance of water balance. Plasma osmolality...
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Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia
BackgroundThe gut-derived metabolite Trimethylamine N-oxide (TMAO) and its precursors - betaine, carnitine, choline, and deoxycarnitine – have been...
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Development and evaluation of serological screening based on one dried plasma spot for HIV, syphilis, and HCV
BackgroundIn the effort to prevent and control HIV/AIDS, China has established a national sentinel surveillance system. However, some sentinel sites...
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Effects of excipients on the interactions of self-emulsifying drug delivery systems with human blood plasma and plasma membranes
Due to its versatility in formulation and manufacturing, self-emulsifying drug delivery systems (SEDDS) can be used to design parenteral...
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Comparison of plasma and neuroimaging biomarkers to predict cognitive decline in non-demented memory clinic patients
BackgroundPlasma biomarkers of Alzheimer’s disease (AD) pathology, neurodegeneration, and neuroinflammation are ideally suited for secondary...
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Regulation of the Effective Circulating Volume and the Sodium Balance
As mentioned in Chap. 1 , the kidney plays a key role in maintaining the composition and volume of extracellular...
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Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma
BackgroundThe expression of aquaporin 4 (AQP4) and intermediate filament (IF) proteins is altered in malignant glioblastoma (GBM), yet the expression...
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Plasma Stability and Plasma Metabolite Concentration–Time Profiles of Oligo(Lactic Acid)8-Paclitaxel Prodrug Loaded Polymeric Micelles
Paclitaxel (PTX) is a frequently prescribed chemotherapy drug used to treat a wide variety of solid tumors. Oligo(lactic acid) 8 -PTX prodrug (o(LA) 8 -PT...
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Associations of plasma neurofilament light chain with cognition and neuroimaging measures in community-dwelling early old age men
BackgroundPlasma neurofilament light chain (NfL) is a promising biomarker of neurodegeneration with potential clinical utility in monitoring the...
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Confirming size-exclusion chromatography as a clinically relevant extracellular vesicles separation method from 1mL plasma through a comprehensive comparison of methods
BackgroundExtracellular vesicles (EVs) are amongst the most promising candidates for develo** blood-based biomarkers. However, patient sample...
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Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment
BackgroundPlasma phosphorylated tau (p-tau) has emerged as a promising biomarker for Alzheimer’s disease (AD). Studies have reported strong...
