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Single-cell transcriptomic analysis reveals tumor cell heterogeneity and immune microenvironment features of pituitary neuroendocrine tumors
BackgroundPituitary neuroendocrine tumors (PitNETs) are one of the most common types of intracranial tumors. Currently, the cellular characteristics...
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Single-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage–tumor interaction axes among different lineages of pituitary neuroendocrine tumors
BackgroundPituitary neuroendocrine tumors (PitNETs) are common gland neoplasms demonstrating distinctive transcription factors. Although the role of...
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Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis
Pituitary neuroendocrine tumors (PitNETs) are common, generally benign tumors with complex clinical characteristics related to hormone hypersecretion...
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Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors
We aimed to identify the druggable cell-intrinsic vulnerabilities and target-based drug therapies for PitNETs using the high-throughput drug...
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Growth hormone proteoformics atlas created to promote predictive, preventive, and personalized approach in overall management of pituitary neuroendocrine tumors
Human growth hormone (GH) is the indispensable hormone for the maintenance of normal physiological functions of the human body, including the growth,...
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Benign and Malignant Tumors of the Pituitary Gland
Pituitary glandPituitary gland tumors represent approximately 10–15% of all brain tumorsBrain tumor and the most common neoplasmsNeoplasm of the...
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Muti-omics integration analysis revealed molecular network alterations in human nonfunctional pituitary neuroendocrine tumors in the framework of 3P medicine
Nonfuctional pituitary neuroendocrine tumor (NF-PitNET) is highly heterogeneous and generally considered a common intracranial tumor. A series of...
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Missing pieces of the pituitary puzzle: participation of extra-adenohypophyseal placode-lineage cells in the adult pituitary gland
The pituitary gland is a major endocrine tissue composing of two distinct entities, the adenohypophysis (anterior pituitary, cranial placode origin)...
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Overview of omics biomarkers in pituitary neuroendocrine tumors to design future diagnosis and treatment strategies
Pituitary neuroendocrine tumors (PitNETs) are the second most common type of intracranial neoplasia. Since their manifestation usually causes hormone...
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Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis
The purpose of this study was to analyze the impact of copy number variations (CNV) on sporadic pituitary neuroendocrine tumors (PitNETs) prognosis,...
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Central Nervous System Tumors
The central nervous system (CNS) is the part of the nervous system comprising the brain and the spinal cord. CNS tumors are a heterogeneous group of...
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Phosphorylation of β-catenin at Serine552 correlates with invasion and recurrence of non-functioning pituitary neuroendocrine tumours
Non-functioning pituitary tumours (NF-PitNETs) are common intracranial benign neoplasms that can exhibit aggressive behaviour by invading...
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A History of Immune and Neuroendocrine System Interactions
The purpose of this chapter is to provide a twentieth century history of neuroendocrine and immune systems and the interactions of their components....
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The kinome, cyclins and cyclin-dependent kinases of pituitary adenomas, a look into the gene expression profile among tumors from different lineages
BackgroundPituitary adenomas (PA) are the second most common intracranial tumors and are classified according to hormone they produce, and the...
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The Epidemiology of Brain and Spinal Cord Tumors
CNS tumors are a diverse group of neoplasmsNeoplasm that emerge from a variety of different CNSCentral Nervous System (CNS) cell types. These tumors...
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Energy Balance and Neuroendocrine-Immune Regulation in Chronic Inflammatory and Neoplastic Diseases: An Evolutionary Perspective
The central nervous and immune systems are often in competition for energy substrates. After infection or injury, energy expenditure typically...
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Germline whole genome sequencing in adults with multiple primary tumors
Multiple primary tumors (MPTs) are a harbinger of hereditary cancer syndromes. Affected individuals often fit genetic testing criteria for a number...
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Aggressive variants of prostate cancer: underlying mechanisms of neuroendocrine transdifferentiation
Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on increased androgen receptor (AR) signaling. Therefore,...
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Glioneuronal and Neuronal Tumors of the Central Nervous System
Glioneuronal and neuronal tumorsGlioneuronal and neuronal tumors (GNT) (GNTs) are rare neoplasmsNeoplasm composed of neural and glial elements...
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Brain Control over Pituitary Gland Hormones
Endocrine organs release their products, hormones, into peripheral blood to travel great distances to exert their biological effects. The brain is...