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Solar Radiation and Phototoxicity of Cosmetics: Avenues of In Vitro Skin Models
Skin is the body’s largest organ, performing several critical functions, including photoprotection and thermoregulation. The skin comprises three...
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Evaluation of the skin phototoxicity of systemically administered pharmaceuticals in Sprague–Dawley rats
In vivo phototoxicity testing is important for predicting drug-induced phototoxicity in humans. Currently, there is no internationally validated in...
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Hydrogel Containing Silibinin-Loaded Pomegranate Oil-Based Nanocapsules for Cutaneous Application: In Vitro Safety Investigation and Human Skin Biometry and Permeation Studies
In previous studies, we developed a hydrogel formulation containing silibinin-loaded pomegranate oil nanocapsules (HG-NCSB) that had improved in vivo ...
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Evaluation of the acute toxicity, phototoxicity and embryotoxicity of a residual aqueous fraction from extract of the Antarctic moss Sanionia uncinata
BackgroundUltraviolet (UV) radiation is the main exogenous inductor of skin damage and so photoprotection is important to control skin disorders. The...
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Mosquito larvae exposed to a sublethal dose of photosensitive insecticides have altered juvenile development but unaffected adult life history traits
BackgroundLarvicides are critical for the control of mosquito-borne diseases. However, even sublethal exposure to a larvicide can alter development...
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Optogenetics and Light-Sheet Microscopy
Light-sheet microscopy is a powerful method for imaging small translucent samples in vivo, owing to its unique combination of fast imaging speeds,...
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Safety assessment of cocamidopropyl betaine, a cosmetic ingredient
Cocamidopropyl betaine (CAPB) is a surfactant derived from coconut oil that is widely used in cosmetics and personal products for several purposes,...
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A NIR Fluorescent Probe Benzopyrylium Perchlorate-based for Visual Sensing and Imaging of SO2 Derivatives in Living Cells
Endogenous sulfur dioxide (SO 2 ), as a gas signal molecule, has a certain physiological functions. Understanding the role of endogenous SO 2 in human...
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F127/chlorin e6-nanomicelles to enhance Ce6 solubility and PDT-efficacy mitigating lung metastasis in melanoma
Photodynamic Therapy (PDT) is a promising paradigm for treating cancer, especially superficial cancers, including skin and oral cancers. However, the...
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Quinolones
Nalidixic acid was the first quinolone introduced in 1962. Structural changes have resulted in an extended spectrum and better pharmacokinetics...
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Cosmetic Ingredients: Various Efficacy-Based Testing Methods in the 3D Skin-Based Model Systems
The 3D skin model is a highly physiological, three-dimensional cellular system of human epidermal keratinocytes (HEK) for in vitro investigations. It...
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Nanotechnologies in Oncology
Nano-oncology, the application of nanomedicine to cancer treatments, has the potential to transform clinical oncology by enhancing the efficacy of...
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Nanotechnologies in Oncology
Nano-oncology, the application of nanomedicine to cancer treatments, has the potential to transform clinical oncology by enhancing the efficacy of...
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Sunscreens: Toxic Effects as Determined by Biomarkers
Biomarkers are known to occur in body fluids such as blood or tissues that can be used as a sign of normal or abnormal processes. Genomic and...
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Progress and recent trends in photodynamic therapy with nanoparticles
BackgroundPhotodynamic therapy (PDT) is an emerging treatment option for various therapeutic areas owing to its outstanding advantages compared with...
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Infectious Virus Tracking by Fluorescent Live Cell Imaging in Primary Cells
To successfully infect a cell, HIV-1 has to overcome several host barriers while exploiting cellular cofactors. HIV-1 infection is highly inefficient...
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In vitro assessment of the photo(geno)toxicity associated with Lapatinib, a Tyrosine Kinase inhibitor
The epidermal growth factor receptors EGFR and HER2 are the main targets for tyrosine kinase inhibitors (TKIs). The quinazoline derivative lapatinib...
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