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Phase II Detoxification Enzymes
Phase I enzymes catalyze the activation metabolism of foreign compounds. Their functionalization reactions incorporate a functional group into a...
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Consistent efficacy outcomes between phase 2 and phase 3 trials in Crohn’s disease or ulcerative colitis in adults: a meta-analysis
IntroductionThe approval of novel biologic agents and small molecules for the treatment of Crohn's disease (CD) and ulcerative colitis (UC) is...
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Identification of phase-I and phase-II metabolites and the metabolic pathway of the novel synthetic cannabinoid 5F-EDMB-PICA in vitro
5F-EDMB-PICA is a newly emerged synthetic cannabinoid which has been characterized in relevant literature in recent years. Although phase-I...
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Dose selection for aztreonam-avibactam, including adjustments for renal impairment, for Phase IIa and Phase III evaluation
PurposeA series of iterative population pharmacokinetic (PK) modeling and probability of target attainment (PTA) analyses based on emerging data...
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Analysis of Phase-Separated Biomolecular Condensates in Cancer
Phase-separated biomolecular condensates play important roles in virtually all cellular processes, and their dysregulation is associated with many...
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Phase I Activation Enzymes
A vast majority of chemical reactions in living cells exhibit kinetic barriers that prevent the reactions from occurring spontaneously. Kinetic...
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Collective Cellular Phase Transitions in Cancer
The growth and metastasis of tumors are increasingly recognized to be an inherently collective, multiscale problem, wherein understanding at the...
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Mechanism of phase condensation for chromosome architecture and function
Chromosomal phase separation is involved in a broad spectrum of chromosome organization and functional processes. Nonetheless, the intricacy of this...
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Experimental Medicine Approaches in Early-Phase CNS Drug Development
Traditionally, Phase 1 clinical trials were largely conducted in healthy normal volunteers and focused on collection of safety, tolerability, and...
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Neuromodulation of inhibitory control using phase-lagged transcranial alternating current stimulation
BackgroundTranscranial alternating current stimulation (tACS) is a prominent non-invasive brain stimulation method for modulating neural oscillations...
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The acute phase reactant orosomucoid-2 directly promotes rheumatoid inflammation
Acute phase proteins involved in chronic inflammatory diseases have not been systematically analyzed. Here, global proteome profiling of serum and...
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Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials
Cannabis use disorder (CUD) is widespread, and there is no pharmacotherapy to facilitate its treatment. AEF0117, the first of a new pharmacological...
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Physiological and pathological effects of phase separation in the central nervous system
Phase separation, also known as biomolecule condensate, participates in physiological processes such as transcriptional regulation, signal...
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Criticality in Alzheimer’s and healthy brains: insights from phase-ordering
Criticality, observed during second-order phase transitions, is an emergent phenomenon. The brain operates near criticality where complex systems...
