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Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment
Periodontitis is a complex chronic inflammatory disease. The invasion of pathogens induces the inflammatory microenvironment in periodontitis. Cell...
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The effects of berteroin on inflammatory mediators and antioxidant enzymes expression in human periodontal ligament cells
Berteroin is a bioactive substance classified as an isothiocyanate found in cruciferous vegetables such as cabbage, arugula, and salad leaves. In...
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Small Extracellular Vesicles from Periodontal Ligament Stem Cells Primed by Lipopolysaccharide Regulate Macrophage M1 Polarization via miR-433-3p Targeting TLR2/TLR4/NF-κB
Lipopolysaccharide (LPS) is regarded as the main pathogenic factor of periodontitis. Mesenchymal stem cell–derived small extracellular vesicles...
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MicroRNA-223 negatively regulates the osteogenic differentiation of periodontal ligament derived cells by directly targeting growth factor receptors
BackgroundMicroRNA (miRNA) is accepted as a critical regulator of cell differentiation. However, whether microRNA-223 (miR-223) could affect the...
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Finite Element Study of Periodontal Ligament Properties for a Maxillary Central Incisor and a Mandibular Second Molar Under Percussion Conditions
PurposeThe quantitative percussion diagnostics (QPD) response of a mandibular second molar and a maxillary central incisor including their supporting...
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The role of non-steroidal anti-inflammatory drugs as adjuncts to periodontal treatment and in periodontal regeneration
Periodontitis is the sixth most prevalent chronic disease globally and places significant burdens on societies and economies worldwide. Behavioral...
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CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy
As a chronic inflammatory disease, periodontitis involves many biological processes including autophagy. At the same time, casein kinase 2...
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Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration
Conventional treatment to periodontal and many other bone defects requires the use of barrier membranes to guided tissue regeneration (GTR) and...
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Selection and validation of reference gene for RT-qPCR studies in co-culture system of mouse cementoblasts and periodontal ligament cells
ObjectiveRT-qPCR is a reliable method for gene expression analysis, but the accuracy of the quantitative data depends on the appropriate selection of...
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Periodontal Disease
Gingivitis and periodontitis are inflammatory conditions caused by the formation and persistence of microbial biofilms on the hard, non-shedding...
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PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis
BackgroundPeriodontal ligament stem cells (PDLSCs) are important seed cells for tissue engineering to realize the regeneration of alveolar bone....
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CTHRC1 Knockdown Promotes Inflammatory Responses Partially by p38 MAPK Activation in Human Periodontal Ligament Cells
Collagen triple helix repeat containing 1 (CTHRC1), a secreted glycoprotein, is widely expressed in many tissues. It has been recently defined as a...
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Extracellular vesicles from the inflammatory microenvironment regulate the osteogenic and odontogenic differentiation of periodontal ligament stem cells by miR-758-5p/LMBR1/BMP2/4 axis
BackgroundExtracellular vesicles (EVs) play a key role in constructing a microenvironment that favors the differentiation of stem cells. The present...
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Galectin-1 Inhibited LPS-Induced Autophagy and Apoptosis of Human Periodontal Ligament Stem Cells
Periodontitis is a widespread human chronic inflammatory disease of the tooth-surrounding tissues, which induces the destruction of periodontium and...
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Periodontal Cell Therapy: A Systematic Review and Meta-analysis
Background: Periodontitis is a chronic inflammatory disease characterized by the loss of tooth-supporting tissues (or periodontium) leading to the...
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Cell Sheet Technology: An Emerging Approach for Tendon and Ligament Tissue Engineering
Tendon and ligament injuries account for a substantial proportion of disorders in the musculoskeletal system. While non-operative and operative...
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Electrospun Polysaccharides for Periodontal Tissue Engineering: A Review of Recent Advances and Future Perspectives
Periodontitis is the leading cause of tooth loss among the adult population. Indeed, conventional treatment modalities have specific challenges such...
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Ligament injury in adult zebrafish triggers ECM remodeling and cell dedifferentiation for scar-free regeneration
After traumatic injury, healing of mammalian ligaments is typically associated with fibrotic scarring as opposed to scar-free regeneration. In...
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Glipizide Alleviates Periodontitis Pathogenicity via Inhibition of Angiogenesis, Osteoclastogenesis and M1/M2 Macrophage Ratio in Periodontal Tissue
New consensus indicates type 2 diabetes mellitus (T2DM) and periodontitis as comorbidity and may share common pathways of disease progression....
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Effect of teeth clenching on handgrip force in adult men: role of periodontal mechanoreceptors
PurposeVoluntary teeth clenching is shown to increase the strength of muscle reflexes contributing to the improvement of postural stability. However,...
