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Patient-Derived Xenografts Methods and Protocols
This detailed volume explores the dynamic landscape of patient-derived xenograft (PDX) generation and applications. After a few chapters examining...
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Patient-Derived Xenograft Models for Leukemias
Patient-derived xenograft (PDX) modeling is a valuable tool for the study of leukemia pathogenesis, progression, and therapy response. Engraftment of...
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Patient-Derived Xenograft Models for Translational Prostate Cancer Research and Drug Development
Patient-derived xenografts (PDXs) are a valuable preclinical research platform generated through transplantation of a patient’s resected tumor into...
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Generation of Metastatic Cholangiocarcinoma Patient-Derived Xenograft Models
Cholangiocarcinoma (CCA) poses a substantial clinical hurdle as it is often detected at advanced metastatic stages with limited therapeutic options....
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Patient-Derived Xenograft Models in Cancer Research: Methodology, Applications, and Future Prospects
Patient-derived xenografts (PDXs) have emerged as a pivotal tool in translational cancer research, addressing limitations of traditional methods and...
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A Humanized Patient-Derived Xenograft Model for Pancreatic Cancer
Pancreatic cancer is associated with a high mortality rate, and there are still very few effective treatment options. Patient-derived xenografts have...
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Development and Expansion of Patient-Derived Xenografts for Endometrial Cancer
Patient-Derived Xenografts (PDXs) are established by implanting a fragment of a patient tumor into rodents either subcutaneously or orthotopically....
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Patient-Derived Xenografts: A Valuable Preclinical Model for Drug Development and Biomarker Discovery
Patient-derived xenografts (PDXs), established by implanting patient tumor cells into immunodeficient mice, offer a platform for faithfully...
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Patient-Derived Xenografts: Historical Evolution, Immunocompromised Host Models, and Translational Significance
Patient-derived xenografts (PDXs) represent a critical advancement in preclinical cancer research, wherein human tumor samples are implanted into...
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Promising preclinical patient-derived organoid (PDO) and xenograft (PDX) models in upper gastrointestinal cancers: progress and challenges
Gastrointestinal (GI) cancers (gastric cancer, oesophageal cancer, liver cancer, colorectal cancer, etc.) are the most common cancers with the...
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Assessing Protein Expression in Patient-Derived Xenografts Using Western Blotting
The use of patient-derived xenografts (PDXs) in cancer research is increasing due to their ability to closely mimic the features of patient tumors....
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Generation, evolution, interfering factors, applications, and challenges of patient-derived xenograft models in immunodeficient mice
Establishing appropriate preclinical models is essential for cancer research. Evidence suggests that cancer is a highly heterogeneous disease. This...
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Genomic and transcriptomic analysis of a diffuse pleural mesothelioma patient-derived xenograft library
BackgroundDiffuse pleural mesothelioma (DPM) is an aggressive malignancy that, despite recent treatment advances, has unacceptably poor outcomes....
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Patient-derived xenograft (PDX) models, applications and challenges in cancer research
The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in...
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Humanized Patient-Derived Xenograft Models of Ovarian Cancer
In vivo modeling of cancer is a critical step in testing novel therapeutic strategies to advance patient care. Here we describe how to develop a...
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Bioengineered RNA Therapy in Patient-Derived Organoids and Xenograft Mouse Models
Therapeutic RNAs, such as antisense oligonucleotides (ASOs), aptamers, small-interfering RNAs (siRNAs), microRNAs (miRs or miRNAs), messenger RNAs...
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Establishment of experimental salivary gland cancer models using organoid culture and patient-derived xenografting
PurposeDepending on its histological subtype, salivary gland carcinoma (SGC) may have a poor prognosis. Due to the scarcity of preclinical...
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Biological evaluation of novel gemcitabine analog in patient-derived xenograft models of pancreatic cancer
Gemcitabine (Gem) has been a standard first-line drug for pancreatic cancer (PCa) treatment; however, Gem's rapid metabolism and systemic instability...
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Establishment of a high-fidelity patient-derived xenograft model for cervical cancer enables the evaluation of patient’s response to conventional and novel therapies
BackgroundRecurrent or metastatic cervical cancer (r/m CC) often has poor prognosis owing to its limited treatment options. The development of novel...
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Deep whole genome sequencing identifies recurrent genomic alterations in commonly used breast cancer cell lines and patient-derived xenograft models
BackgroundBreast cancer cell lines (BCCLs) and patient-derived xenografts (PDXs) are the most frequently used models in breast cancer research....
