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TMEM151A variants associated with paroxysmal kinesigenic dyskinesia
TMEM151A , located at 11q13.2 and encoding transmembrane protein 151A, was recently reported as causative for autosomal dominant paroxysmal...
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Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease
Adult kidney organoids have been described as strictly tubular epithelia and termed tubuloids. While the cellular origin of tubuloids has remained...
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1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease. Cyst development in ADPKD involves abnormal...
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P2 purinergic receptor dysregulation in urologic disease
P2 purinergic receptors are involved in the normal function of the kidney, bladder, and prostate via signaling that occurs in response to...
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An Introduction to Recent Approaches Underlying Mechanistic Insights Harboring Oncobiology
Oncobiology is rapidly progressing, with many ongoing studies aimed at comprehending the intricate mechanisms underpinning cancer initiation,...
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An Introduction to Recent Approaches Underlying Mechanistic Insights Harboring Oncobiology
The field of oncobiology is witnessing rapid progress, with numerous ongoing studies dedicated to comprehending the intricate mechanisms underlying...
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Transplant and Kidney Repair
Kidney injury including acute and chronic types will end in transient or permanent renal failure. Even patients with an episode of acute kidney...
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The role of the metabolite cargo of extracellular vesicles in tumor progression
Metabolomic reprogramming in tumor and stroma cells is a hallmark of cancer but understanding its effects on the metabolite composition and function...
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A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A3 receptor
There is a growing interest in understanding the binding kinetics of compounds that bind to G protein-coupled receptors prior to progressing a lead...
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Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections
The lipid kinases that generate the lipid signalling phosphoinositides have been established as fundamental signalling enzymes that control numerous...
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Intronic PRRT2 mutation generates novel splice acceptor site and causes paroxysmal kinesigenic dyskinesia with infantile convulsions (PKD/IC) in a three generation family
BackgroundMutations in PRRT2 cause autosomal dominant paroxysmal kinesigenic dyskinesia with infantile convulsions (PKD/IC).
Case presentation ...
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Profiling of a suramin-derived compound library at recombinant human P2Y receptors identifies NF272 as a competitive but non-selective P2Y2 receptor antagonist
Extracellular nucleotides mediate multiple physiological effects such as proliferation, differentiation, or induction of apoptosis through G...
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Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors
The diacylglycerol kinases (DGKs) are master regulator kinases that control the switch from diacylglycerol (DAG) to phosphatidic acid (PA), two...
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GPNMB methylation: a new marker of potentially carcinogenic colon lesions
BackgroundEpigenetic plays an important role in colorectal neoplasia process. There is a need to determine sound biomarkers of colorectal cancer...
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Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling
As a major sentinel of adaptive immunity, T cells seek and destroy diseased cells using antigen recognition to achieve molecular specificity....
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Bone Morphogenetic Protein-7 and Its Role in Acute Kidney Injury and Chronic Kidney Failure
Bone morphogenetic protein (BMP)-7 is required for embryonic kidney development, plays a functional role in the adult kidney as renal hormone for...
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Catechol-O-Methyltransferase (COMT): An Update on Its Role in Cancer, Neurological and Cardiovascular Diseases
Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but...
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Using WormBase: A Genome Biology Resource for Caenorhabditis elegans and Related Nematodes
WormBase ( www.wormbase.org ) provides the nematode research community with a centralized database for...