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Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells
BackgroundPromyelocytic leukemia protein (PML) is a primary component of PML nuclear bodies (PML-NBs). PML and PML-NBs play critical roles in...
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Genome-wide analysis of long noncoding RNA profiles in pseudorabies-virus-infected PK15 cells
Recently, an increasing number of studies have shown that long noncoding RNAs (lncRNAs) are involved in host metabolism after infection with...
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Low molecular weight sulfated chitosan efficiently reduces infection capacity of porcine circovirus type 2 (PCV2) in PK15 cells
BackgroundPorcine circovirus type 2 (PCV2)-associated diseases are a major problem for the swine industry worldwide. In addition to vaccines, the...
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PK15 cell line stably overexpressing IL2 enhances PCV2 replication
Porcine circovirus type 2 (PCV2) is the primary agent responsible for porcine circovirus-associated diseases (PCVADs), which is acknowledged as one...
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Coinfection with PEDV and BVDV induces inflammatory bowel disease pathway highly enriched in PK-15 cells
BackgroundFrom the 1078 diarrhea stools tested in our survey from 2017 to 2020 in local area of China, PEDV was the key pathogen that was closely...
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Transcriptomic analysis reveals impact of gE/gI/TK deletions on host response to PRV infection
BackgroundPseudorabies virus (PRV) causes substantial losses in the swine industry worldwide. Attenuated PRV strains with deletions of...
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Resistance to pseudorabies virus by knockout of nectin1/2 in pig cells
Pseudorabies virus (PRV) is a pig pathogen that causes substantial economic losses to the pig industry. Infection of host cells by PRV is mediated by...
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Cell-Based Biosensor to Visualize Nitric Oxide Release from Living Cells for Toxicity Assessment
Fluorescence imaging provides a powerful technique to observe biomolecular dynamics in living systems, if fluorescent biosensors for the relevant...
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Host Interferon-Stimulated Gene 20 Inhibits Pseudorabies Virus Proliferation
Host interferon-stimulated gene 20 (ISG20) exerts antiviral effects on viruses by degrading viral RNA or by enhancing IFN signaling. Here, we...
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Isolation and artificial production of atypical porcine pestivirus, using the swine-kidney-derived cell line SK-L
Congenital tremor (CT) in piglets was first reported in 1922, and although the causative pathogen was unknown for many years, atypical porcine...
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Acute transcriptomic changes in murine RAW 264.7 cells following pseudorabies virus infection
Next-generation sequencing enables the evaluation of gene expression changes resulting from virus–host interactions at the RNA level. Pseudorabies...
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Pseudorabies virus UL38 attenuates the cGAS-STING signaling pathway by recruiting Tollip to promote STING for autophagy degradation
Natural immunity is the first defense line of the host immune system, which plays a significant role in combating foreign pathogenic microorganisms....
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Evaluation of immunogenicity of gene-deleted and subunit vaccines constructed against the emerging pseudorabies virus variants
BackgroundPseudorabies (PR) (also called Aujeszky’s disease, AD) is a serious infectious disease affecting pigs and other animals worldwide. The...
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HMGB1 is involved in viral replication and the inflammatory response in coxsackievirus A16-infected 16HBE cells via proteomic analysis and identification
Coxsackievirus A16 (CV-A16) is still an important pathogen that causes hand, foot and mouth disease (HFMD) in young children and infants worldwide....
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Porcine circovirus type 3 capsid protein induces NF-κB activation and upregulates pro-inflammatory cytokine expression in HEK-293T cells
Porcine circovirus type 3 (PCV3) has been widely detected throughout the world since it was first discovered on pig farms in 2015. PCV3 is closely...
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Analysis of PERV-C superinfection resistance using HA-tagged viruses
BackgroundUsing pigs as organ donors has advanced xenotransplantation to the point that it is almost ready for clinical use. However, there is still...
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Effect of the Porcine STC-1 Gene on Autophagy and Mitochondrial Function as Induced by Serum Starvation
Stanniocalcin-1 (STC-1) is a glycoprotein hormone involved in calcium/phosphorus metabolism and direct inhibition of bone and muscle growth. The aim...
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Rare isolation of human-tropic recombinant porcine endogenous retroviruses PERV-A/C from Göttingen minipigs
BackgroundPorcine endogenous retroviruses (PERVs) can infect human cells and pose a risk for xenotransplantation when pig cells, tissues or organs...
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Genome-Wide PERV Inactivation in Pigs Using CRISPR/Cas9
The shortage of organs for transplantation is probably the biggest unmet medical need. A potential problem with the clinical use of porcine...
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In Vitro Infectious Risk Assessment of Heliothis virescens ascovirus 3j (HvAV-3j) toward Non-target Vertebrate Cells
As specific pathogens of noctuid pests, including Spodoptera exigua , S. litura , Helicoverpa armigera , and Mythimna separata , ascoviruses are suitable...
