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PIM3 kinase promotes tumor metastasis in hepatoblastoma by upregulating cell surface expression of chemokine receptor cxcr4
Patients presenting with metastatic hepatoblastoma have limited treatment options and survival rates as low as 25%. We previously demonstrated that...
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LncRNA SNHG1 Accelerates Cell Proliferation, Migration, and Invasion of Hepatoblastoma Through Mediating miR-6838-5p/PIM3/RhoA Axis
Hepatoblastoma (HB) is a common primary liver malignant tumor in children. Long non-coding RNAs (lncRNAs) are closely engaged in HB progression. The...
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CRISPR/Cas9-mediated knockout of PIM3 suppresses tumorigenesis and cancer cell stemness in human hepatoblastoma cells
Hepatoblastoma remains one of the most difficult childhood tumors to treat and is alarmingly understudied. We previously demonstrated that Proviral...
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Selectivity and potency of natural product PIM kinase inhibitors identified by in silico docking
PIM3 (Proviral Integration site for Maloney murine leukemia virus kinase 3) is a proto-oncogene with serine/threonine kinase activity that prevents...
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CDK9 inhibition induces epigenetic reprogramming revealing strategies to circumvent resistance in lymphoma
Diffuse large B-cell lymphoma (DLBCL) exhibits significant genetic heterogeneity which contributes to drug resistance, necessitating development of...
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Role of PIM Kinase Inhibitor in the Treatment of Alzheimer’s Disease
Alzheimer’s disease (AD), a neurodegenerative disorder, is the most prevalent form of senile dementia, causing progressive deterioration of...
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Oxidative Stress in Cancer: Therapeutic Implications of Small-Molecule Kinase Inhibitors
Cancer-targeted therapeutics have heavily relied on develo** small-molecule kinase inhibitors as anticancer agents in the last two decades. The...
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Oxidative Stress in Cancer: Therapeutic Implications of Small-Molecule Kinase Inhibitors
Cancer-targeted therapeutics have heavily relied on develo** small-molecule kinase inhibitors as anticancer agents in the last two decades. The...
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Targeting Pim kinases in hematological cancers: molecular and clinical review
Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/STAT and tyrosine...
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Synthesis of 2-oxoquinoline derivatives as dual pim and mTORC protein kinase inhibitors
Compound VBT-5445 was identified as an inhibitor to block the association of Pim and the protein Enhancer of Decap** 3 (EDC3), a Pim substrate,...
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Pim1 promotes IFN-β production by interacting with IRF3
The Pim (proviral integration site for Moloney murine leukemia virus) proteins compose a serine threonine kinase family whose members regulate cell...
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2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
Angiogenesis is a crucial process in the progression of various pathologies, like solid tumors, wet age-related macular degeneration, and chronic...
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Carboxamide appended quinoline moieties as potential anti-proliferative agents, apoptotic inducers and Pim-1 kinase inhibitors
The targeted approach of protein kinases (PKs), as PKs are the main regulators of cell survival and proliferation, has been a promising strategy for...
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BEX1 supports the stemness of hepatoblastoma by facilitating Warburg effect in a PPARγ/PDK1 dependent manner
BackgroundHepatoblastoma (HB) is a highly aggressive paediatric malignancy that exhibits a high presence of cancer stem cells (CSCs), which related...
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MicroRNAs from edible plants reach the human gastrointestinal tract and may act as potential regulators of gene expression
MicroRNAs (miRNAs) are small single-stranded non-coding RNA molecules that regulate gene expression at the post-transcriptional level. A...
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ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer
BackgroundZNF322A is an oncogenic transcription factor that belongs to the Cys2His2-type zinc-finger protein family. Accumulating evidence suggests...
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Epithelial–Mesenchymal Transition and Cancer Stem Cells
Epithelial–mesenchymal transition (EMT), a cellular phenotypic change from epithelial to mesenchymal-like features, is related to the resistance and...
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The RNA sequencing results revealed the expression of different genes and signaling pathways during chemotherapy resistance in peripheral T-cell lymphoma
BackgroundPeripheral T-cell lymphoma (PTCL) is a subtype of non-Hodgkin's lymphoma that occurs primarily at extranodal sites and is commonly treated...
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Systems pharmacology and multi-scale mechanism of Enicostema axillare bioactives in treating Alzheimer disease
As a progressive neurological disease with increased morbidity and mortality, Alzheimer Disease (AD) is characterized by neuron damage that controls...
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Analysis of candidate biomarkers and related transcription factors involved in the development and restoration of stress-induced gastric ulcer by transcriptomics
Stress-induced gastric ulcer is one of the common complications affecting patients after trauma, mainly leading to gastrointestinal bleeding and...
