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Surrogacy of one-year survival for overall survival in advanced hepatocellular carcinoma
BackgroundThe increasing number of sequential treatments complicates the evaluation of overall survival (OS) in clinical trials for hepatocellular...
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Overall survival of patients with thyroid cancer in Martinique (2008–2018)
BackgroundThyroid cancer (TC) overall survival at 5 years was estimated at 97% in mainland France over 2010–2015. Its prognosis is known to be...
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Progression-free survival as a surrogate endpoint for overall survival in patients with relapsed or refractory multiple myeloma
ObjectivesThe goal of the research was to assess the quantitative relationship between median progression-free survival (PFS) and median overall...
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Development and validation of a nomogram for predicting overall survival in patients with early-onset endometrial cancer
BackgroundThis study aimed to investigate the differences in the clinicopathological characteristics of younger and older patients with endometrial...
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Functional genetic variants of GEN1 predict overall survival of Chinese epithelial ovarian cancer patients
BackgroundInherited variations in DNA double-strand break (DSB) repair pathway are known to influence ovarian cancer occurrence, progression and...
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Development and validation of a nomogram for predicting overall survival in patients with sinonasal mucosal melanoma
BackgroundSinonasal mucosal melanoma (SNMM) is a relatively rare malignant tumour with a poor prognosis. This study was designed to identify...
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Effect of adjuvant radiotherapy on overall survival and breast cancer-specific survival of patients with malignant phyllodes tumor of the breast in different age groups: a retrospective observational study based on SEER
PurposeMalignant phyllodes tumor of the breast (MPTB) is a rare type of breast cancer, with an incidence of less than 1%. The value of adjuvant...
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Construction, validation, and visualization of a web-based nomogram to predict overall survival in small-cell lung cancer patients with brain metastasis
IntroductionBrain metastasis (BM) is an aggressive complication with an extremely poor prognosis in patients with small-cell lung cancer (SCLC). A...
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Support to early clinical decisions in drug development and personalised medicine with checkpoint inhibitors using dynamic biomarker-overall survival models
Longitudinal models of biomarkers such as tumour size dynamics capture treatment efficacy and predict treatment outcome (overall survival) of a...
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Overall survival of patients with hepatocellular carcinoma treated with sintilimab and disease outcome after treatment discontinuation
BackgroundThe use of Anti-PD-1 therapy has yielded promising outcomes in hepatocellular carcinoma (HCC). However, limited research has been conducted...
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Surgery versus no surgery in platinum-sensitive relapsed ovarian cancer: final overall survival analysis of the SOC-1 randomized phase 3 trial
Surgery for platinum-sensitive, relapsed ovarian cancer (PSROC) is widely practiced but had contradictory survival outcomes in previous studies. In...
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Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer
Circulating tumor DNA (ctDNA) sequencing guides therapy decisions but has been studied mostly in small cohorts without sufficient follow-up to...
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A Four Amino Acid Metabolism-Associated Genes (AMGs) Signature for Predicting Overall Survival Outcomes and Immunotherapeutic Efficacy in Hepatocellular Carcinoma
Metabolites are important indicators of cancer and mutations in genes involved in amino acid metabolism may influence tumorigenesis. Immunotherapy is...
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Machine learning prediction of pathological complete response and overall survival of breast cancer patients in an underserved inner-city population
BackgroundGeneralizability of predictive models for pathological complete response (pCR) and overall survival (OS) in breast cancer patients requires...
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Durvalumab after chemoradiotherapy for locally advanced non-small cell lung cancer prolonged distant metastasis-free survival, progression-free survival and overall survival in clinical practice
BackgroundIn clinical practice, the effect of durvalumab and radiation pneumonitis (RP) on survival after intensity-modulated radiotherapy (IMRT) is...
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Identification on surrogating overall survival with progression-free survival of first-line immunochemotherapy in advanced esophageal squamous cell carcinoma—an exploration of surrogate endpoint
BackgroundOverall survival (OS) is the gold standard to assess novel therapeutics to treat cancer. However, to identify early efficacy and speed up...
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Overall survival of patients with metastatic breast cancer in Sweden: a nationwide study
BackgroundBreast cancer is the most common cancer among women in Sweden. Whereas survival for the overall breast cancer population is...
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Machine learning models predict overall survival and progression free survival of non-surgical esophageal cancer patients with chemoradiotherapy based on CT image radiomics signatures
PurposeTo construct machine learning models for predicting progression free survival (PFS) and overall survival (OS) with esophageal squamous cell...
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Nomograms for predicting overall survival in colorectal cancer patients with metastasis to the liver, lung, bone, and brain
BackgroundThe aim of this study was to identify the heterogeneous and homogeneous prognostic factors associated with distant metastasis to the liver,...
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Prognostic model on overall survival in elderly nasopharyngeal carcinoma patients: a recursive partitioning analysis identifying pre-treatment risk stratification
BackgroundWe aimed to evaluate the optimal management for elderly patients with nasopharyngeal carcinoma (NPC) with intensity-modulated radiotherapy...
