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Chondrocyte death involvement in osteoarthritis
Chondrocyte apoptosis is known to contribute to articular cartilage damage in osteoarthritis and is correlated to a number of cartilage disorders....
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Sappanone a alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis via activating the SIRT1/Nrf2 signaling pathway
Osteoarthritis (OA) is a common degenerative joint disease that cause pain and disability in adults. Chondrocyte ferroptosis is found to be involved...
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CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF-κB pathway
BackgroundOsteoarthritis (OA), the most common joint disease, is linked with chondrocyte apoptosis and extracellular matrix (ECM) degradation....
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Higher ratios of chondrocyte to mesenchymal stem cells elevate the therapeutic effects of extracellular vesicles harvested from chondrocyte/mesenchymal stem cell co-culture on osteoarthritis in a rat model
Extracellular vesicles (EVs) may have a key therapeutic role and offer an innovative treatment for osteoarthritis (OA). Studies have shown that ratio...
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Polydactyly-derived allogeneic chondrocyte cell-sheet transplantation with high tibial osteotomy as regenerative therapy for knee osteoarthritis
Allogeneic cell therapies are not fully effective in treating osteoarthritis of the knee (OAK). We recently reported that transplantation of...
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Mitochondria-Related Gene MAOB is a Key Biomarker of Osteoarthritis and Inhibition of Its Expression Reduces LPS-induced Chondrocyte Damage
The mitochondria are an important organelle in cells responsible for producing energy, and its abnormal function is closely related to the occurrence...
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Klf10 is involved in extracellular matrix calcification of chondrocytes alleviating chondrocyte senescence
Osteoarthritis (OA) is a chronic degenerative disease resulting joint disability and pain. Accumulating evidences suggest that chondrocyte...
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Osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease characterized by deterioration of the articular cartilage. OA is a major cause of disability and...
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Understanding the Influence of Local Physical Stimuli on Chondrocyte Behavior
Investigating the mechanobiology of chondrocytesChondrocyte is challenging due to the complex micromechanical environment of cartilageCartilage...
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Advances in the study of mitophagy in osteoarthritis
Osteoarthritis (OA), characterized by cartilage degeneration, synovial inflammation, and subchondral bone remodeling, is among the most common...
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Molecular mechanisms of environmental pollutant-induced cartilage damage: from developmental disorders to osteoarthritis
The objective of the present study was to review the molecular mechanisms of the adverse effects of environmental pollutants on chondrocytes and...
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SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression
Osteoarthritis (OA) causes serious changes in the metabolic and signaling pathways of chondrocytes, including the mitogen-activated protein kinase...
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The emerging role of the semaphorin family in cartilage and osteoarthritis
In the pathogenesis of osteoarthritis, various signaling pathways may influence the bone joint through a common terminal pathway, thereby...
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The Effect of JAK Inhibitor Tofacitinib on Chondrocyte Autophagy
Osteoarthritis (OA) is a multifactorial disease of the whole joint that has a complex pathogenesis. There is currently no cure for OA. Tofacitinib is...
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The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation
During the development of the appendicular skeleton, the cartilaginous templates undergo hypertrophic differentiation and remodels into bone, except...
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LIPUS regulates the progression of knee osteoarthritis in mice through primary cilia-mediated TRPV4 channels
Osteoarthritis (OA) is a common disease in middle-aged and elderly people. An imbalance in calcium ion homeostasis will contribute to chondrocyte...
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Deletion of DYRK1A Accelerates Osteoarthritis Progression Through Suppression of EGFR-ERK Signaling
Dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) signaling is involved in the dynamic balance of catabolism and anabolism in...
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G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1
BackgroundApoptosis of chondrocyte is involved in osteoarthritis (OA) pathogenesis, and mechanical stress plays a key role in this process by...
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CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy
Osteoarthritis (OA) is the most prevalent chronic degenerative joint disease with few treatment options. The pathogenesis of OA is characterized by...
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Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis
BackgroundOsteoarthritis (OA) is a degenerative joint disease with lacking effective prevention targets. A disintegrin and metalloproteinase with...
