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Exercise Improves Orofacial Pain and Modifies Neuropeptide Expression in a Rat Model of Parkinson’s Disease
Pain is a common non-motor symptom of Parkinson's disease (PD), which often occurs in the early disease stages. Despite the high prevalence, it...
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Analgesic Effects of Acupuncture on Orofacial Pain
Orofacial pain includes trigeminal neuralgia, headache, migraine, painful temporomandibular dysfunction, toothache, and other oral and facial pain....
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Comparative study of the effects of ibuprofen, acetaminophen, and codeine in a model of orofacial postoperative pain in male and female rats
Pain management is a primary goal after oral surgeries, but little is known about sex differences in the sensitivity to analgesics. This study aimed...
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Antinociceptive effects of bupivacaine and its sulfobutylether-β-cyclodextrin inclusion complex in orofacial pain
Bupivacaine hydrochloride (BVC) represents an option to produce long-lasting analgesia, and complexation in cyclodextrins has shown improvements in...
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Botulinum Toxin in Dentistry and Treatment of Chronic Orofacial Pain
Chronic pain of the hard and soft tissues of the face and oral cavity is generally known as orofacial pain (OFP). OFP is a major issue in dentistry...
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N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways
BackgroundNociceptin/orphanin FQ (N/OFQ) has been revealed to play bidirectional roles in orofacial pain modulation. Calcitonin gene-related peptide...
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N-methyl-D-aspartate Receptor Subunits 2A and 2B Mediate Connexins and Pannexins in the Trigeminal Ganglion Involved in Orofacial Inflammatory Allodynia during Temporomandibular Joint Inflammation
Temporomandibular joint osteoarthritis (TMJOA) is a severe form of temporomandibular joint disorders (TMD), and orofacial inflammatory allodynia is...
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Transient Receptor Potential (TRP) Ion Channels in Orofacial Pain
Orofacial pain, including temporomandibular joint disorders pain, trigeminal neuralgia, dental pain, and debilitating headaches, affects millions of...
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Development of a Nanoformulation for Oral Protein Administration: Characterization and Preclinical Orofacial Antinociceptive Effect
AbstractNanoencapsulation is a valid alternative for the oral administration of peptide drugs and proteins, as nanoparticles protect them from...
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Facemap: a framework for modeling neural activity based on orofacial tracking
Recent studies in mice have shown that orofacial behaviors drive a large fraction of neural activity across the brain. To understand the nature and...
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TET1 Participates in Complete Freund’s Adjuvant-induced Trigeminal Inflammatory Pain by Regulating Kv7.2 in a Mouse Model
Trigeminal inflammatory pain is one of the most severe pain-related disorders in humans; however, the underlying mechanisms remain largely unknown....
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SAHA Inhibits Somatic Hyperalgesia Induced by Stress Combined with Orofacial Inflammation Through Targeting Different Spinal 5-HT Receptor Subtypes
Epigenetic regulation of gene expression has been implicated in the development of chronic pain. However, little is known about whether this...
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Connexin 36 Mediates Orofacial Pain Hypersensitivity Through GluK2 and TRPA1
Trigeminal neuralgia is a debilitating condition, and the pain easily spreads to other parts of the face. Here, we established a mouse model of...
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Rab11a in the spinal cord: an essential contributor to complete Freund’s adjuvant-induced inflammatory pain in mice
Inflammatory pain is a commonly observed clinical symptom in a range of acute and chronic diseases. However, the mechanism of inflammatory pain is...
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Enkephalin Rescues Temporomandibular Joint Pain-Related Behavior in Rats
Temporomandibular joint disorders include a variety of clinical syndromes that are difficult to manage if associated with debilitating severe jaw...
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Modulatory Processes in Craniofacial Pain States
Pain is a common symptom associated with many disorders affecting the craniofacial tissues that include the teeth and their supporting structures,...
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Sex Differences in Pain and Its Treatment
Pain is a highly personal experience. Pain is often considered to be a purely neurologic phenomenon, but in actuality, it is a combination of both...
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Introduction to Acute, Chronic, and Episodic Pain
Pain places an enormous burden on the healthcare system as well as the quality of life of individuals all around the world. With regard to the...
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Optogenetic Inhibition of Glutamatergic Neurons in the Dysgranular Posterior Insular Cortex Modulates Trigeminal Neuropathic Pain in CCI-ION Rat
In individuals with chronic neuropathic pain, the posterior insular cortex (PIC) has been found to exhibit increased glutamatergic activity, and the...
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Optogenetic Approach in Trigeminal Neuralgia and Potential Concerns: Preclinical Insights
The integration of optogenetics in the trigeminal pain circuitry broadens and reinforces existing pain investigations. Similar to research on spinal...
