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The Olfactory System
This volume discusses the latest approaches used to investigate molecular biology and physiology in the peripheral and central olfactory system....
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Neonatal olfactory bulbectomy causes dendritic spine retraction in dorsal hippocampal CA3 neurons in female rats and spatial learning deficits in male rats
Olfactory bulbectomy (OBX) is an experimental strategy that is widely employed because it produces changes at different levels (from behavioral to...
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Quantification of identifying cognitive impairment using olfactory-stimulated functional near-infrared spectroscopy with machine learning: a post hoc analysis of a diagnostic trial and validation of an external additional trial
BackgroundWe aimed to quantify the identification of mild cognitive impairment and/or Alzheimer’s disease using olfactory-stimulated functional...
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Memory effects of visual and olfactory landmark information in human wayfinding
Non-human animals are exceptionally good at using smell to find their way through the environment. However, the use of olfactory cues for human...
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ErbB4 deficiency exacerbates olfactory dysfunction in an early-stage Alzheimer’s disease mouse model
Olfactory dysfunction is increasingly recognized as an early indicator of Alzheimer’s disease (AD). Aberrations in GABAergic function and the...
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The development and testing of olfactory-based neurofeedback for the EEG alpha rhythm
This study presents the development and initial testing of a novel olfactory-based neurofeedback (NFB) system, utilizing electroencephalographic...
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Does Olfactory Training Improve Brain Function and Cognition? A Systematic Review
Olfactory training (OT), or smell training,consists of repeated exposure to odorants over time with the intended neuroplastic effect of improving or...
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Olfactory Dysfunction in Schizophrenia: Evaluating Olfactory Abilities Across Species
Though understudied relative to perturbations in the auditory and visual domains, olfactory dysfunction is a common symptom of schizophrenia. Over...
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Amelioration of Cognitive and Olfactory System Deficits in APOE4 Transgenic Mice with DHA Treatment
Olfactory dysfunction and atrophy of olfactory brain regions are observed early in mild cognitive impairment and Alzheimer disease. Despite...
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On the Similarity of the Mechanisms of Processing Olfactory, Auditory, and Visual Information in the CNS: A Hypothesis
Abstract —A possible mechanism for processing odors in a neural network that includes the olfactory bulb, the piriform cortex, the olfactory tubercle,...
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Augmentation of tumor expression of HLA-DR, CXCL9, and CXCL10 may improve olfactory neuroblastoma immunotherapeutic responses
BackgroundOlfactory neuroblastoma is a rare malignancy of the anterior skull base typically treated with surgery and adjuvant radiation. Although...
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Intranasal Insulin Enhances Intracerebroventricular Streptozotocin–Induced Decrease in Olfactory Discriminative Learning via Upregulation of Subventricular Zone–Olfactory Bulb Neurogenesis in the Rat Model
Olfactory perception and learning play a vital role in the animal’s entire life for habituation and survival. Insulin and insulin receptor signaling...
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Complex Impairments to the Olfactory Sensory System in Schizophrenia
This article analyzes published data and shows that the functioning of the olfactory system is impaired in schizophrenia. Structural and functional...
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α-Synuclein aggregation in the olfactory bulb induces olfactory deficits by perturbing granule cells and granular–mitral synaptic transmission
Olfactory dysfunction is an early pre-motor symptom of Parkinson’s disease (PD) but the neural mechanisms underlying this dysfunction remain largely...
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Changes in the Spectral Characteristics and Level of Coherence of Local Field Potentials in the Rat Olfactory Bulb during Xylazine-Tiletamine-Zolazepam Anesthesia
Local field potentials (LFP) recorded in the olfactory bulb (OB) is largely generated in its local neural networks, is directly related to the...
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Transplantation of Nasal Olfactory Mucosa Mesenchymal Stem Cells Benefits Alzheimer’s Disease
Alzheimer’s disease (AD) is a common neurodegenerative disease that contributes to 60–70% of dementia in elderly people and is currently incurable....
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Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory–entorhinal–amygdaloid axis in Alzheimer’s and Parkinson’s diseases
BackgroundSmell impairment is one of the earliest features in Alzheimer’s (AD) and Parkinson’s diseases (PD). Due to sex differences exist in terms...
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Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing
The olfactory system’s ability to detect and discriminate between the vast array of chemicals present in the environment is critical for an animal’s...
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Prenatal Hypoxia Impairs Olfactory Function in Postnatal Ontogeny in Rats
Analysis of the age-related dynamics of olfactory behavior in the odor preference and food search testsshowed that all male Wistar rats, regardless...
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Olfactory coding in honeybees
With less than a million neurons, the western honeybee Apis mellifera is capable of complex olfactory behaviors and provides an ideal model for...
