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1. Viral Vector-Induced Ocular Hypertension in Mice

   Viral transduction of the mouse trabecular meshwork using a variety of transgenes associated with glaucoma generates an inducible and reproducible...

   J. Cameron Millar, Yogapriya Sundaresan, ... Abbot F. Clark in Retinal Ganglion Cells

   Protocol 2023
   

2. Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension​

   Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that...

   Shruthi Karnam, Shubham Maurya, ... Karsten Gronert in Acta Neuropathologica Communications

   Article Open access 12 April 2024
   

3. Laser-Induced Ocular Hypertension in a Mouse Model of Glaucoma

   Glaucoma is a neurodegenerative disease that leads to the loss of retinal ganglion cells (RGC) and thus to blindness. There are numerous experimental...

   José M. Ramírez, Elena Salobrar-García, ... Ana I. Ramírez in Retinal Ganglion Cells

   Protocol 2023
   

4. Silicone Oil-Induced Ocular Hypertension Glaucoma Model (SOHU) in Rodent and Nonhuman Primate

   In this chapter, we describe a clinically relevant inducible and reversible ocular hypertension glaucoma model, which mimics the secondary glaucoma...

   Fang Fang, Jie Zhang, Yang Hu in Retinal Ganglion Cells

   Protocol 2023
   

5. ATP-P2X₇R-mediated microglia senescence aggravates retinal ganglion cell injury in chronic ocular hypertension

   Background

   Dysfunction of microglia during aging affects normal neuronal function and results in the occurrence of neurodegenerative diseases. Retinal...

   Miao Wei, Guowei Zhang, ... Min Ji in Journal of Neuroinflammation

   Article Open access 31 July 2023
   

6. Human adipose tissue-derived stem cell extracellular vesicles attenuate ocular hypertension-induced retinal ganglion cell damage by inhibiting microglia- TLR4/MAPK/NF-κB proinflammatory cascade signaling

   Microglia-mediated neuroinflammatory responses are recognized as a predominant factor during high intraocular pressure (IOP)-induced retinal and...

   Shangli Ji, Yanfang Peng, ... Shibo Tang in Acta Neuropathologica Communications

   Article Open access 19 March 2024
   

7. Microbead-Induced Ocular Hypertension in a Rodent Model of Glaucoma

   Glaucoma is an irreversible blinding disease characterized by the loss of retinal ganglion cells. Development of therapeutics relies on suitable...

   Ben Mead in Retinal Ganglion Cells

   Protocol 2023
   

8. Genome editing in the treatment of ocular diseases

   Genome-editing technologies have ushered in a new era in gene therapy, providing novel therapeutic strategies for a wide range of diseases, including...

   Elliot H. Choi, Susie Suh, ... Krzysztof Palczewski in Experimental & Molecular Medicine

   Article Open access 01 August 2023
   

9. Transient but not chronic hyperglycemia accelerates ocular glymphatic transport

   Glymphatic transport is vital for the physiological homeostasis of the retina and optic nerve. Pathological alterations of ocular glymphatic fluid...

   Christine Delle, **aowei Wang, ... Maiken Nedergaard in Fluids and Barriers of the CNS

   Article Open access 12 March 2024
   

10. Application of mendelian randomization in ocular diseases: a review

    Ocular disorders can significantly lower patients’ quality of life and impose an economic burden on families and society. However, for the majority...

    **ran Zhang, Weichen Yuan, ... Fangkun Zhao in Human Genomics

    Article Open access 17 June 2024
    

11. Neuro-ocular Effects of Spaceflight

    During long-duration spaceflight, approximately half of the astronauts develop a unique set of structural and functional neuro-ophthalmic changes to...

    Karina Marshall-Goebel in Handbook of Space Pharmaceuticals

    Reference work entry 2022
    

12. Ocular Injection Techniques for Retinitis Pigmentosa: Intravitreal, Subretinal, and Suprachoroidal

    Ocular gene therapyGene therapies represents an emerging and promising therapeutic approach for the treatment of several of the inherited retinal...

    Ioana Scherbakova, Sara D. Ragi, Tarun Sharma in Retinitis Pigmentosa

    Protocol 2023
    

13. Airborne particulate matter (PM_2.5) triggers ocular hypertension and glaucoma through pyroptosis

    Background

    Particulate matter (PM) is strongly linked to human health and has detrimental effects on the eye. Studies have, however, focused on the...

    Li** Li, Chao **ng, ... Yuan Lei in Particle and Fibre Toxicology

    Article Open access 04 March 2021
    

14. Ocular complications with the use of radium-223: a case series

    Background

    Radium-223 is used for the treatment of osseous metastases in castrate-resistant prostate cancer, and has been shown to increase time to...

    Julie R. Bloom, Alexandra G. Castillejos, ... Richard G. Stock in Radiation Oncology

    Article Open access 17 May 2022

15. Metabolomic phenoty** of obesity for profiling cardiovascular and ocular diseases

    Background

    We aimed to evaluate the impacts of metabolomic body mass index (metBMI) phenotypes on the risks of cardiovascular and ocular diseases...

    **ting Zhong, Shaoying Tan, ... Wei Wang in Journal of Translational Medicine

    Article Open access 12 June 2023
    

16. Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases

    Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption and subsequent release of cellular contents and...

    Meini Chen, Rong Rong, **aobo **a in Journal of Neuroinflammation

    Article Open access 14 July 2022
    

17. The Development and Evaluation of Phase Transition Microemulsion for Ocular Delivery of Acetazolamide for Glaucoma Treatment

    The aim of this study was to develop microemulsion (ME) formulation with possible phase transition into liquid crystals upon ocular application to...

    Lubna M. Abd El Wahab, Ebtessam A. Essa, ... Mona F. Arafa in AAPS PharmSciTech

    Article Open access 23 November 2022
    

18. Hypertension secondary to nitric oxide depletion produces oxidative imbalance and inflammatory/fibrotic outcomes in the cornea of C57BL/6 mice

    Arterial hypertension (AH) leads to oxidative and inflammatory imbalance that contribute to fibrosis development in many target organs. Here, we...

    Álvaro Santana-Garrido, Claudia Reyes-Goya, ... Alfonso Mate in Journal of Physiology and Biochemistry

    Article Open access 09 August 2022
    

19. Ocular Pharmacology

    Ocular Pharmacology deals with the treatment of ocular disorders by administering drugs through the eye or systemically. Various pharmacokinetic...

    Abialbon Paul in Introduction to Basics of Pharmacology and Toxicology

    Chapter 2021
    

20. Comparison of In Vitro Corneal Permeation and In Vivo Ocular Bioavailability in Rabbits of Three Marketed Latanoprost Formulations

    Background and Objective

    All latanoprost formulations currently available for the treatment of glaucoma or ocular hypertension contain the same...

    Laure Chauchat, Camille Guerin, ... Jean-Paul Renard in European Journal of Drug Metabolism and Pharmacokinetics

    Article Open access 08 September 2023