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c-Myc-induced long noncoding RNA MIRE cooperates with hnRNPK to stabilize ELF2 mRNA and promotes clear cell renal cell carcinogenesis
Elevated expression of c-Myc is associated with a variety of human cancers including clear cell renal cell carcinoma (ccRCC). Increasing evidence...
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How germ granules promote germ cell fate
Germ cells are the only cells in the body capable of giving rise to a new organism, and this totipotency hinges on their ability to assemble...
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Cell Biology of the Life Cycle of Giardia intestinalis
Giardia intestinalis (G. lamblia, G. duodenalis) is the agent of Giardiasis, a disease widely prevalent throughout the world. It has a life cycle...
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Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes
Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while...
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Clinical and Therapeutic Aspects of Sideroblastic Anaemia with B-Cell Immunodeficiency, Periodic Fever and Developmental Delay (SIFD) Syndrome: a Systematic Review
Background and PurposeSideroblastic anaemia with B-cell immunodeficiency, periodic fever and developmental delay (SIFD) syndrome is a novel rare...
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Assessment of ASC Oligomerization by Flow Cytometry
Inflammasomes are multiprotein complexes that critically control different aspects of innate and adaptive immunity. Upon activation, inflammasome...
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Surface Passivation of Carbon Dots for Tunable Biological Performance
Recent investigations were shifted this trend toward exploring the biomedical applicability of CDs, relevant to chronic diseases. Herein, a...
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Lecture 1: Cells and Tissues
The cell is the basic structural and functional unit of the body. There are many different types. A group of similar cells adjacent to each other,...
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A Ciliary Branched Actin Network Drives Photoreceptor Disc Morphogenesis
The light-detecting organelle of the photoreceptor cell is a modified primary cilium, called the outer segment. The outer segment houses hundreds of...
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Repetitive mild TBI causes pTau aggregation in nigra without altering preexisting fibril induced Parkinson’s-like pathology burden
Population studies have shown that traumatic brain injury (TBI) is associated with an increased risk for Parkinson’s disease (PD) and among U.S....
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Heat shock proteins-driven stress granule dynamics: yet another avenue for cell survival
Heat shock proteins (HSPs) are evolutionary conserved ‘stress-response’ proteins that facilitate cell survival against various adverse conditions....
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Isolating Circulating Cancer Stem Cells (CCSCs) from Human Whole Blood
Measuring circulating tumor cells (CTCs) or circulating cancer stem cells (CCSCs) in blood, which shed from primary tumors, is a noninvasive method...
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Lectures 5 and 6: Musculo-Skeletal System
There are 206 bones in the (adult) body, which comprise about 14% of our body mass, and 700 muscles that should comprise about 40% of our body mass.
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The Typical and Atypical Centrioles and Their Potential Roles in the Sperm and Embryo
The embryo of humans and other mammals requires the presence of two subcellular structures, named centrioles. The centrioles act as nucleation points...
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Transcriptional Control in Entamoeba: Something Old, Something New
Entamoeba histolytica is an extracellular protozoan parasite and is a global health problem that kills approximately 100,000 people annually. The...
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Increased Expression of CD74 in Atherosclerosis Associated with Inflammatory Responses of Endothelial Cells and Macrophages
To clarify the relationship between CD74 and atherosclerosis (AS) and the mechanisms in oxidized LDL (ox-LDL)-induced endothelial cell and macrophage...
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Harnessing the MYB-dependent TAL1 5’super-enhancer for targeted therapy in T-ALL
The acquisition of genetic abnormalities engendering oncogene dysregulation underpins cancer development. Certain proto-oncogenes possess several...
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Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death
Alzheimer’s disease (AD) is a neurodegenerative disorder without a cure or prevention to date. Hyperphosphorylated tau forms the neurofibrillary...
