Search
Search Results
-
A Key Transcription Factor Family: Nuclear Receptors
In this chapter, a highly interesting family of ligand-inducible transcription factors, referred to as nuclear receptors, will be presented. Nuclear...
-
Nuclear Receptors in Energy Metabolism
Nuclear receptors are master regulators of energy metabolism through the conversion of extracellular signals into gene expression signatures. The...
-
Nuclear Receptors in Ovarian Function
The ovary undergoes cycles of hormone production that regulate physiological changes necessary for folliculogenesis, ovulation and luteinisation,...
-
Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders on a disease spectrum that are...
-
Nuclear Receptors and Lipid Sensing
Fluctuations in concentration of diverse lipid classes occur in response to diet and metabolism. These changes are managed and mediated by a cell...
-
Circadian Rhythm and Nuclear Receptors
All life of Earth has evolved mechanisms to track time. This permits anticipation of predictable changes in light/dark, and in most cases also...
-
Nuclear Receptors in Pregnancy and Outcomes: Clinical Perspective
Pregnancy is characterised by profound hormonal and metabolic changes in the mother. Both oestrogen and progesterone, along with their respective...
-
Nuclear Receptors The Art and Science of Modulator Design and Discovery
Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these...
-
Natural compounds targeting nuclear receptors for effective cancer therapy
Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate gene expression both spatially and temporally. Numerous...
-
Cardiovascular Physiopathology of Angiotensin II and Its Plasma and Nuclear Envelop Membranes’ Receptors
In 1934, the discovery of angiotensin IIAngiotensin II opened an Eldorado in the field of the cardiovascular system. Until today, this Eldorado is...
-
Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy
BackgroundCytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a hallmark of the amyotrophic lateral sclerosis and...
-
Nuclear receptors: a bridge linking the gut microbiome and the host
BackgroundThe gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, and fungi within the gastrointestinal tract. The gut...
-
Drugging the Undruggable: Targeting the N-Terminal Domain of Nuclear Hormone Receptors
This chapter focuses on the development of drugsDrugs targeting the N-terminal domain of nuclear hormone receptors, using progress with the androgen...
-
Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics
Recent advances have brought forth the complex interplay between tumor cell plasticity and its consequential impact on drug resistance and tumor...
-
Significance of the Vitamin D Receptor on Crosstalk with Nuclear Receptors and Regulation of Enzymes and Transporters
The vitamin D receptor (VDR), in addition to other nuclear receptors, the pregnane X receptor (PXR) and constitutive androstane receptor (CAR), is...
-
Nuclear Hormone Receptors and Host-Virus Interactions
Viruses are a diverse class of obligate parasites that require a host to propagate. Viruses have evolved to exploit host signaling pathways to...
-
-
Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma
BackgroundNeuroblastoma (NB), a childhood tumor derived from the sympathetic nervous system, presents with heterogeneous clinical behavior. While...
-
Genomic Insights into Non-steroidal Nuclear Receptors in Prostate and Breast Cancer
Alterations in transcriptional programs are a fundamental feature of prostate (PCa) and breast cancerBreast cancers (BrCa), and frequently target the...