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Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification
Metabolites are intermediate products of cellular metabolism catalysed by various enzymes. Metabolic remodelling, as a biochemical fingerprint of...
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Tumor-suppressive functions of protein lysine methyltransferases
Protein lysine methyltransferases (PKMTs) play crucial roles in histone and nonhistone modifications, and their dysregulation has been linked to the...
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Emerging posttranslational modifications and their roles in DNA damage response
Posttranslational modifications (PTMs), occurring on various histones and nonhistone proteins, greatly enrich the diversity of the proteome, thereby...
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SRF is a nonhistone methylation target of KDM2B and SET7 in the regulation of skeletal muscle differentiation
The demethylation of histone lysine residues, one of the most important modifications in transcriptional regulation, is associated with various...
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Posttranslational modification and beyond: interplay between histone deacetylase 6 and heat-shock protein 90
Posttranslational modification (PTM) and regulation of protein stability are crucial to various biological processes. Histone deacetylase 6 (HDAC6),...
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Histone deacetylase III interactions with BK polyomavirus large tumor antigen may affect protein stability
BackgroundHuman polyomavirus BK (BKPyV) causes associated nephropathy and contributes to urinary tract cancer development in renal transplant...
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Ribosomal S6 protein kinase 4 promotes resistance to EZH2 inhibitors in glioblastoma
Glioblastoma (GBM) is a highly malignant type of brain tumor with limited treatment options. Recent research has focused on epigenetic regulatory...
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Protein arginine methyltransferases: promising targets for cancer therapy
Protein methylation, a post-translational modification (PTM), is observed in a wide variety of cell types from prokaryotes to eukaryotes. With recent...
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Beyond metabolic waste: lysine lactylation and its potential roles in cancer progression and cell fate determination
BackgroundLactate is an important metabolite derived from glycolysis under physiological and pathological conditions. The Warburg effect reveals the...
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The multifunctional protein HMGB1: 50 years of discovery
Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin, HMGB1 is now known to regulate diverse biological...
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Transcriptional Expression of Histone Acetyltransferases and Deacetylases During the Recovery of Acute Exercise in Mouse Hippocampus
Protein acetylation, which is dynamically maintained by histone acetyltransferases (HATs) and deacetylases (HDACs), might play essential roles in...
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Gene regulation by histone-modifying enzymes under hypoxic conditions: a focus on histone methylation and acetylation
Oxygen, which is necessary for sustaining energy metabolism, is consumed in many biochemical reactions in eukaryotes. When the oxygen supply is...
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PHD finger protein 20-like protein 1 (PHF20L1) in ovarian cancer: from its overexpression in tissue to its upregulation by the ascites microenvironment
BackgroundOvarian cancer is the most aggressive gynecological malignancy. Transcriptional regulators impact the tumor phenotype and, consequently,...
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The role of epigenetic modifications in Colorectal Cancer Metastasis
Distant metastasis is the major contributor to the high mortality rate of colorectal cancer (CRC). To overcome the poor prognosis caused by distant...
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Protein post-translational modifications in the regulation of cancer hallmarks
Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function regulation, play important roles in regulating a variety...
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The mechanism of HMGB1 secretion and release
High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In the nucleus,...
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High-Mobility Group Box 1 in Spinal Cord Injury and Its Potential Role in Brain Functional Remodeling After Spinal Cord Injury
High-mobility group box 1 (HMGB1) is a nonhistone nuclear protein, the functions of which depend on its subcellular location. It is actively or...
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MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1
Senescence, an intricate and inevitable biological process, characterized by the gradual loss of homeostasis and declining organ functions. The...
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LSD1: more than demethylation of histone lysine residues
Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified nuclear protein with histone demethylase activity. In...
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Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma
BackgroundIntrahepatic cholangiocarcinoma (ICCA) is a heterogeneous group of malignant tumors characterized by high recurrence rate and poor...
