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Head-to-head comparison of two loop-mediated isothermal amplification (LAMP) kits for diagnosis of malaria in a non-endemic setting
BackgroundLight microscopy and rapid diagnostic tests (RDT) have long been the recommended diagnostic methods for malaria. However, in recent years,...
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Loop-mediated isothermal amplification identifies nematode Leidynema in the hindgut of non-pest cockroach
Cockroach microbiome studies generally focus on pest cockroach species belonging to the Blattidae and Ectobiidae families. There are no reports...
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Development of a rapid diagnostic test based on loop-mediated isothermal amplification to identify the most frequent non-typhoidal Salmonella serovars from culture
Identification of Salmonella serovars is performed by conventional seroagglutination or sequencing. These methods are labor-intensive and require...
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Visualization and development of colorimetric loop-mediated isothermal amplification for the rapid detection and diagnosis of paramphistome infection: colorimetric PAR-LAMP
Colorimetric detection can be applied to differentiate between positive and negative conditions. It can be coupled with loop-mediated isothermal...
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A novel detection method based on MIRA-CRISPR/Cas13a-LFD targeting the repeated DNA sequence of Trichomonas vaginalis
BackgroundTrichomonas vaginalis is a protozoan parasite, widely recognized as the most prevalent non-viral sexually transmitted infection (STI)...
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A LAMP-based assay for the molecular detection of group B Streptococcus.
PurposeStreptococcus agalactiae remains a major pathogen in human health, especially in neonatal infection. Detection in pregnant women is essential...
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Development of environmental loop-mediated isothermal amplification (eLAMP) diagnostic tool for Bulinus truncatus field detection
BackgroundGlobal changes are resha** the distribution of vector-borne diseases by spreading vectors to previously non-endemic areas. Since 2013,...
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Comparison of the ScreenFire and Xpert HPV assays for the detection of human papillomavirus and cervical precancer among women living with HIV in Malawi
BackgroundThe World Health Organization recommends human papillomavirus (HPV) testing for primary cervical cancer screening, including among women...
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Physicochemical Characterization of Three Active Pharmaceutical Ingredients for Compound Glycyrrhizin Solid Formulation and Compatibility Analysis via Thermal and Non-thermal Techniques
PurposeThis study aimed to develop evaluation methods for multicomponent system interactions between drug excipients of three active pharmaceutical...
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Small Molecule Screening Discovers Compounds that Reduce FMRpolyG Protein Aggregates and Splicing Defect Toxicity in Fragile X-Associated Tremor/Ataxia Syndrome
Expansion of CGG trinucleotide repeats in 5′ untranslated region of the FMR1 gene is the causative mutation of neurological diseases such as fragile...
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Cyclodextrin/Adamantane-Grafted Polyethylene Glycol–Based Self-assembling Constructs for Topical Delivery of Ketorolac Tromethamine: Formulation, Characterization, and In Vivo Studies
Topical formulation of non-steroidal anti-inflammatory drugs (NSAIDs) exhibits many advantages over the oral administration route, such as avoiding...
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Molecular Diagnosis of Dengue
Several protocols for genomic amplification using reverse transcription followed by polymerase chain reaction (RT-PCR), important in the...
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Spectrum and characterization of bi-allelic variants in MMAB causing cblB-type methylmalonic aciduria
Pathogenic variants in MMAB cause cblB -type methylmalonic aciduria, an autosomal-recessive disorder of propionate metabolism. MMAB encodes...
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A fast extraction-free isothermal LAMP assay for detection of SARS-CoV-2 with potential use in resource-limited settings
BackgroundTo retain the spread of SARS-CoV-2, fast, sensitive and cost-effective testing is essential, particularly in resource limited settings...
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Monkeypox Diagnosis in Clinical Settings: A Comprehensive Review of Best Laboratory Practices
An outbreakOutbreak of monkeypox (Mpox) was reported in more than 40 countries in early 2022. Accurate diagnosisDiagnosis of MpoxMpox can be...
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Evolution of Viral Diagnostics: A Peek into Time
Time and again, viral infections have shaken the world to its core. From serious pandemic situation like COVID-19 to common influenza episodes,...
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Role of the Laboratory in the Diagnosis of Poxvirus Infections
Although WHO-led global efforts led to eradication of smallpoxSmallpox over four decades ago, other poxvirusesPoxvirus, especially monkeypoxMonkeypox...
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Trends in the Determination of Antimicrobial Resistance in Aquaculture and Fisheries
Antimicrobial resistance (AMR) and its transfer is considered a new pollutant in the aquatic system as it acts as root cause of shifting...
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Detection Methods for H1N1 Virus
Influenza A virus H1N1, a respiratory virus transmitted via droplets and responsible for the global pandemic in 2009, belongs to the Orthomyxoviridae...
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Trends in the Determination of Antimicrobial Resistance in Aquaculture and Fisheries
Antimicrobial resistance (AMR) and its transfer is considered a new pollutant in the aquatic system as it acts as root cause of shifting...