Search
Search Results
-
Long Non-coding RNAs in Cancer
Long non-coding RNAs (lncRNAs) are emerging as cardinal biomarkers for diagnosis, prognosis, and therapy of cancers as well as precise therapeutic...
-
Advances on the Mechanisms and Therapeutic Strategies in Non-coding CGG Repeat Expansion Diseases
Non-coding CGG repeat expansions within the 5′ untranslated region are implicated in a range of neurological disorders, including fragile...
-
Heteromorphismes: Mutations in Non-Coding-DNA Regions
In the following chapter, frequent variants or polymorphisms are presented in an overview. As this Atlas gives examples on structural chromosome...
-
Long Non-coding RNAs in Cancer
Long non-coding RNAs (lncRNAs) are emerging as cardinal biomarkers for diagnosis, prognosis, and therapy of cancers as well as precise therapeutic...
-
DNA Methylation of a Group of Long Non-Coding RNA Genes at Different Stages of Ovarian Cancer Dissemination
There are three types of metastases in ovarian cancer: lymphogenous, hematogenous, and peritoneal. Dissemination of the tumor in the peritoneum is...
-
Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are not translated into proteins. Since their discovery,...
-
Targeting and engineering long non-coding RNAs for cancer therapy
RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or employing RNA molecules for therapeutic purposes. Amongst the most...
-
The Role of Non-coding RNAs in Cerebellar Development
Since the sequencing of the human and various mammalian genomes, it is clear that there are far too few protein-coding genes to specify and...
-
A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer
BackgroundmiR-346 was identified as an activator of Androgen Receptor (AR) signalling that associates with DNA damage response (DDR)-linked...
-
Heteromorphismes: Mutations in Non-Coding-DNA Regions
For a long time, the constitutive heterochromatin has been regarded as neglectable as to its significance of mutations in chromosome structure and...
-
The Role of Non-coding RNAs in Drug Resistance of Cancers
Cancer is a leading cause of mortality in patients worldwide. Some types of cancer treatment are surgery, chemotherapy, radiation therapy, targeted...
-
Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance
Cancer is a complex disease with many contributing factors, and researchers have gained extensive knowledge that has helped them understand the...
-
Non-coding RNAs and Exosomal Non-coding RNAs in Traumatic Brain Injury: the Small Player with Big Actions
Nowadays, there is an increasing concern regarding traumatic brain injury (TBI) worldwide since substantial morbidity is observed after it, and the...
-
Modulation of Long Non-coding RNAs in Cancer
Cancer is associated to uncontrolled growth of cells. It is the second most common cause of death worldwide. Main treatment consists of surgery,...
-
MicroRNAs and Long Non-coding RNAs as Key Targets
Cancer is a potentially fatal and complex genetic disease characterized by the dysregulation of genome stability and cell proliferation, cell...
-
Role of non-coding RNAs in neuroblastoma
Neuroblastoma is known as the most prevalent extracranial malignancy in childhood with a neural crest origin. It has been widely accepted that...
-
Genome sequencing identifies coding and non-coding variants for non-syndromic hearing loss
Hearing loss (HL) is a common heterogeneous trait that involves variants in more than 200 genes. In this study, we utilized exome (ES) and genome...
-
Using coding and non-coding rare variants to target candidate genes in patients with severe tinnitus
Tinnitus is the phantom percept of an internal non-verbal set of noises and tones. It is reported by 15% of the population and it is usually...
-
Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications
Breast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming of energy metabolism is a major...
-
G-quadruplexes from non-coding RNAs
Non-coding RNAs (ncRNAs) are significant regulators of gene expression in a wide range of biological processes, such as transcription, RNA...
