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Nitric Oxide
Nitric oxide (NO) is a gaseous molecule with the chemical formula NO. In biological systems, NO is produced from L-arginine by three distinct NO...
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Nitric Oxide: From Research to Therapeutics
This book entitled "Nitric Oxide: From Research to Therapeutics" includes the most recent information about the role of Nitric Oxide (NO) in...
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Role of Nitric Oxide Synthase and Nitric Oxide Signaling in the Neutrophil Ontogeny and Functions
Neutrophils are the essential guards of the immune system that inactivate different pathogens as well as instruct specific immune responses. Nitric...
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Nitric Oxide Regulation in Microparticles
Nitric oxide (NO) has been widely shown to have a varied roles physiologically. Nitric oxide presence in microparticle has been gaining importance...
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Nitric Oxide and Cardiovascular Health
Nitric oxide (NO) is a diffusible free radical and universal messenger that is produced from L-arginine by three different isoforms of nitric oxide...
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Therapeutic Prospects of Nitric Oxide as an Anti-teratogen
A physical, chemical or biological agent that causes malformation of the embryo of foetus is referred to as teratogen. Foetal abnormalities have...
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Evidence of Nitric Oxide Impairment During Hypertensive Pregnancies
Hypertensive disorders of pregnancy complicate up to 10% of pregnancies worldwide, and they can be classified into (1) gestational hypertension, (2)...
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Nitric Oxide and the Heart Autonomic Nervous System
Nitric oxide (NO) is important in physiological cardiovascular regulation and is involved in the pathophysiology of cardiac disorders. This chapter...
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Nitric Oxide in Major Depressive Disorder
The pathogenesis of mood disorders remains elusive, but it is evident that multiple factors, genetic and environmental, play a crucial role in adult...
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Nitric Oxide in Parkinson’s Disease: Insights into Research and Therapeutics
Parkinson’s disease (PD) is characterized by the symptoms of motor and cognitive deficits. There are several approaches available for the treatment...
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Nitric Oxide and Cardiovascular Diseases: Cardioprotection, Complications and Therapeutics
Perpetually increasing cardiovascular complications significantly contribute to economic slow-down in develo** nations. Indeed, adverse...
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Sex Differences in Stress and Stress Related Neuropsychiatric Disorders: Focus on Nitric Oxide
Sex differences in neuropsychiatric disorders are well reported although the mechanisms remain poorly understood. The prevalence of major depressive...
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Involvement of Nitric Oxide in Insulin Secretion to Carbohydrate Metabolism
Since the discovery of nitric oxide (NO) as an important mediator of vasoregulation, the molecule has been found to be involved in several...
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Anti-pruritic effect of L-carnitine against chloroquine-induced pruritus mediated via nitric oxide pathway
BackgroundPruritus, or itching, is a distressing symptom associated with various dermatological and systemic diseases. L-carnitine (βeta...
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Repurposing nitric oxide donating drugs in cancer therapy through immune modulation
BackgroundNitric oxide-releasing drugs are used for cardiovascular diseases; however, their effects on the tumor immune microenvironment are less...
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Genistein mitigates nitroglycerine-induced migraine: modulation of nitric oxide-mediated vasodilation and oxidative stress
Migraine is a widespread brain condition described by frequent, recurrent episodes of incapacitating, moderate-to-severe headaches with throbbing...
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Translating Nitric Oxide Research to Therapeutics: A Critical Appraisal
Nitric oxide (NO) is a signaling molecule with an extensive range of functions in both health and disease. Initially proposed as a regulator of...