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The Role of Nicotine Metabolic Rate on Nicotine Dependence and Rewarding: Nicotine Metabolism in Chinese Male Smokers and Male Mice
The exact relationship between nicotine metabolism and dependence is not fully understood but is known to be influenced at a molecular level by...
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Anhedonia in Nicotine Dependence
Prior findings indicate that trait anhedonia enhances the likelihood of becoming a tobacco smoker, and preliminary evidence suggests that smoking...
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Behavioral characterization of early nicotine withdrawal in the mouse: a potential model of acute dependence
BackgroundClinical and preclinical research have demonstrated that short-term exposure to nicotine during the initial experimentation stage can lead...
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Common hyper-entropy patterns identified in nicotine smoking, marijuana use, and alcohol use based on uni-drug dependence cohorts
Substance use disorders present similar behaviors and psychopathologies related to impaired decision making/inhibition control and information...
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Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans
RationaleNo previous studies examined the discriminative stimulus effects of intravenous (IV) nicotine in humans.
ObjectivesTo evaluate a pulsed IV...
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Smoking reduction using electronic nicotine delivery systems in combination with nicotine skin patches
Abstract RationaleElectronic nicotine delivery systems (ENDS) are used by smokers seeking to reduce combustible cigarette (CC) use, but the role of...
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Intermittent nicotine access is as effective as continuous access in promoting nicotine seeking and taking in rats
RationaleNicotine is a principal psychoactive agent in tobacco, contributing to tobacco’s addictive potential. Preclinical studies on the effects of...
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Nicotine pharmacokinetics and subjective responses after using nicotine pouches with different nicotine levels compared to combustible cigarettes and moist smokeless tobacco in adult tobacco users
RationaleOral tobacco–derived nicotine products include on!® nicotine pouches (NPs) which are tobacco-leaf free and available in multiple flavors and...
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Biobehavioral and affective stress responses during nicotine withdrawal: Influence of regular cannabis co-use
BackgroundCo-use of cannabis is increasing in nicotine users and presents additional challenges in addressing nicotine dependence. This study...
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The effects of nicotine use during adolescence and young adulthood on gray matter cerebral blood flow estimates
Nicotine and tobacco product (NTP) use remains prevalent in adolescence/young adulthood. The effects of NTPs on markers of brain health during this...
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Modulation of Nicotine-Associated Behaviour in Rats By μ-Opioid Signals from the Medial Prefrontal Cortex to the Nucleus Accumbens Shell
Nicotine addiction is a concern worldwide. Most mechanistic investigations are on nicotine substance dependence properties based on its...
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Acute nicotine administration reduces the efficacy of punishment in curbing remifentanil consumption in a seeking-taking chain schedule of reinforcement
RationaleNicotine dependence is highly comorbid with opioid use disorders (OUDs). The use of nicotine-containing products increases the propensity to...
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Nicotine Pharmacology, Abuse, and Addiction
Despite increased public awareness of the substantial health risks, tobacco use remains one of the greatest public health concerns around the world....
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Histone Methyltransferase G9a Plays an Essential Role on Nicotine Preference in Zebrafish
Psychostimulants regulate behavioral responses in zebrafish via epigenetic mechanisms. We have previously shown that DNA methylation and histone...
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Development of pulsed intravenous nicotine infusions as a model for inhaled nicotine in humans
RationaleAlthough nicotine from cigarettes is delivered in puff-sized amounts, most preclinical and human intravenous (IV) nicotine studies have used...
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Poor inhibitory control predicts sex-specific vulnerability to nicotine rewarding properties in mice
RationaleThe risk of becoming addicted to tobacco varies greatly from individual to individual, raising the possibility of behavioural biomarkers...
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Microglia sustain anterior cingulate cortex neuronal hyperactivity in nicotine-induced pain
BackgroundLong-term smoking is a risk factor for chronic pain, and chronic nicotine exposure induces pain-like effects in rodents. The anterior...
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Adult consequences of repeated nicotine and Δ9-tetrahydrocannabinol (THC) vapor inhalation in adolescent rats
RationaleUse of electronic drug delivery systems (EDDS, “e-cigarettes”) to ingest nicotine and Δ 9 -tetrahydrocannabinol (THC) has surged in...
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Elucidating the reinforcing effects of nicotine: a tribute to Nadia Chaudhri
Nadia Chaudhri worked with us as a graduate student in the Center for Neuroscience at the University of Pittsburgh from 1999 until she earned her PhD...
