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Effect of Neurotropic and Immunotropic Drugs on Leukocyte Elastase Activity In Vitro
Leukocyte elastase is a marker of inflammation. Previously, a relationship was found between the severity of mental disorders in patients and...
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The role of neutrophil elastase in aortic valve calcification
BackgroundCalcific aortic valve disease (CAVD) is the most commonly valvular disease in the western countries initiated by inflammation and abnormal...
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Alpha-7 Nicotinic Receptor Agonist Protects Mice Against Pulmonary Emphysema Induced by Elastase
Pulmonary emphysema is a primary component of chronic obstructive pulmonary disease (COPD), a life-threatening disorder characterized by lung...
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Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients
BackgroundThe risk for symptomatic COVID-19 requiring hospitalization is higher in the older population. The course of the disease in hospitalised...
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Neutrophils and neutrophil extracellular traps in oral health and disease
Neutrophils perform essential functions in antimicrobial defense and tissue maintenance at mucosal barriers. However, a dysregulated neutrophil...
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Placental neutrophil reverse trans-migration and maternal serum neutrophil extracellular trap expression in HIV infection co-morbid pre-eclampsia in women of African ancestry
Neutrophil extracellular traps (NETs) and placental neutrophil reverse transmigration (r-TM) are implicated in the pathogenesis of pre-eclampsia...
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Association of admission neutrophil serine proteinases levels with the outcomes of acute ischemic stroke: a prospective cohort study
BackgroundNeutrophil serine proteinases (NSPs), released by activated neutrophils, are key proteins involved in the pathophysiologic processes of...
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Neutrophil reverse migration
The behavior of neutrophils is very important for the resolution of inflammation and tissue repair. People have used advanced imaging techniques to...
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Synthesis and evaluation of benzenesulfonic acid derivatives as human neutrophil elastase (hNE) inhibitors
Herein we report our investigation concerning the development of Human neutrophil elastase (hNE) inhibitors for the treatment of Acute Respiratory...
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Visualizing NETosis Using a Novel Neutrophil Extracellular Trap-Specific Marker
As the most abundant leukocyte in circulation, the neutrophil plays a far-reaching role in maintaining homeostasis. Within the context of disease,...
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Effects of neutrophil fate on inflammation
IntroductionNeutrophils are important participants in the innate immune response. They rapidly and efficiently identify and clear infectious agents...
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Neutrophil extracellular traps in intracerebral hemorrhage: implications for pathogenesis and therapeutic targets
Intracerebral hemorrhage is a common neurological disease, and its pathological mechanism is complex. As the first recruited leukocyte subtype after...
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Toxoplasma gondii-induced neutrophil extracellular traps are relevant to glycolysis, TLR2, and TLR4 MAPK signaling pathway in goats
Toxoplasma gondii ( T. gondii ) exhibits a significantly high prevalence of infection in goats, leading to adverse consequences such as abortion and...
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Neutrophil sub-types in maintaining immune homeostasis during steady state, infections and sterile inflammation
IntroductionNeutrophils are component of innate immune system and a) eliminate pathogens b) maintain immune homeostasis by regulating other immune...
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Role of Nitric Oxide Synthase and Nitric Oxide Signaling in the Neutrophil Ontogeny and Functions
Neutrophils are the essential guards of the immune system that inactivate different pathogens as well as instruct specific immune responses. Nitric...
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Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases
Systemic autoimmune diseases are characterized by the failure of the immune system to differentiate self from non-self. These conditions are...
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Neutrophil diversity and plasticity: Implications for organ transplantation
Neutrophils, as the first defenders against external microbes and stimuli, are highly active and finely regulated innate immune cells. Emerging...
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Transient receptor potential melastatin 2 regulates neutrophil extracellular traps formation and delays resolution of neutrophil-driven sterile inflammation
The formation of neutrophil extracellular traps (NETs) is a process releasing into the extracellular space networks of chromatin fibers decorated...
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Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental calculi
Dental calculi can cause gingival bleeding and periodontitis, yet the mechanism underlying the formation of such mineral build-ups, and in particular...
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Baicalin promotes antiviral IFNs production and alleviates type I IFN-induced neutrophil inflammation
Type I and III interferons (IFNs) both serve as pivotal components of the host antiviral innate immune system. Although they exert similar antiviral...
