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Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease
Failed proteostasis is a well-documented feature of Alzheimer’s disease, particularly, reduced protein degradation and clearance. However, the...
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Light-Based Neuronal Circuit Probing in Living Brains at High Resolution: Constraints and Layouts for Integrating Neuronal Activity Recording and Modulation in Three Dimensions
Understanding how the brain orchestrates neuronal activity to finely produce and regulate behavior is an intriguing yet challenging task. In the last...
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Molecular blueprints for spinal circuit modules controlling locomotor speed in zebrafish
The flexibility of motor actions is ingrained in the diversity of neurons and how they are organized into functional circuit modules, yet our...
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Analysis of lateral orbitofrontal cortex activation on acquisition of fear extinction and neuronal activities in fear circuit
Inappropriate fear expression and failure of fear extinction are commonly seen in patients with post-traumatic stress disorder (PTSD) and...
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Understanding neural circuit function through synaptic engineering
Synapses are a key component of neural circuits, facilitating rapid and specific signalling between neurons. Synaptic engineering — the synthetic...
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Unveiling the Hidden Impact: Hematoma Volumes Unravel Circuit Disruptions in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) imposes a significant burden on patients, and the volume of hematoma plays a crucial role in determining the severity...
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A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice
Coughing is a respiratory behavior that plays a crucial role in protecting the respiratory system. Here we show that the nucleus of the solitary...
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Spatial transcriptomics reveals the distinct organization of mouse prefrontal cortex and neuronal subtypes regulating chronic pain
The prefrontal cortex (PFC) is a complex brain region that regulates diverse functions ranging from cognition, emotion and executive action to even...
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Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson's disease
Deep brain stimulation (DBS) is a well-established and effective treatment for patients with advanced Parkinson's disease (PD), yet its underlying...
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Nicotinic Receptors of the Neuronal and Non-neuronal Cholinergic Systems as Therapeutic Targets: Opportunities and Limitations
Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughtout the body. Classically, nAChRs were considered to mediate fast synaptic...
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Overnight neuronal plasticity and adaptation to emotional distress
Expressions such as ‘sleep on it’ refer to the resolution of distressing experiences across a night of sound sleep. Sleep is an active state during...
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Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral Thalamus
The thalamocortical (TC) circuit is closely associated with pain processing. The hyperpolarization-activated cyclic nucleotide-gated (HCN) 2 channel...
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A biophysical perspective on the resilience of neuronal excitability across timescales
Neuronal membrane excitability must be resilient to perturbations that can take place over timescales from milliseconds to months (or even years in...
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Cell and circuit complexity of the external globus pallidus
The external globus pallidus (GPe) of the basal ganglia has been underappreciated owing to poor understanding of its cells and circuits. It was...
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Biphasic Cholinergic Modulation of Reverberatory Activity in Neuronal Networks
Acetylcholine (ACh) is an important neuromodulator in various cognitive functions. However, it is unclear how ACh influences neural circuit dynamics...
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Ketamine triggers a switch in excitatory neuronal activity across neocortex
The brain can become transiently disconnected from the environment while maintaining vivid, internally generated experiences. This so-called...
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A brainstem circuit for phonation and volume control in mice
Mammalian vocalizations are critical for communication and are produced through the process of phonation, in which expiratory muscles force air...
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Neural dynamics and architecture of the heading direction circuit in zebrafish
Animals generate neural representations of their heading direction. Notably, in insects, heading direction is topographically represented by the...
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Viral Tools for Neural Circuit Tracing
Neural circuits provide an anatomical basis for functional networks. Therefore, dissecting the structure of neural circuits is essential to...
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Circuit-Specific Control of Blood Pressure by PNMT-Expressing Nucleus Tractus Solitarii Neurons
The nucleus tractus solitarii (NTS) is one of the morphologically and functionally defined centers that engage in the autonomic regulation of...
