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Neural Stem Cell Intervention in Traumatic Brain Injury
Introduction: Traumatic brain injury (TBI)Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide. The secondary brain damage...
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Stem Cell-Based Neural Model Systems for Brain Disorders
This detailed volume presents validated and well-adapted procedures involving humanized and/or stem cell-based neural model systems that have proven...
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Intranasal administration of induced pluripotent stem cell-derived cortical neural stem cell-secretome as a treatment option for Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly, resulting in gradual destruction of cognitive...
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Neural Stem/Progenitor Cell (NSPC) Extraction and Culture
Neural stem–progenitor cells (NSPCs) are multipotent, self-renewing cells that generate radial glial cells (RGC). RGCs then give rise to neurons and...
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Stem Cell Exosomes Improve Survival of Neural Stem Cells after Radiation Exposure
The death of neural stem cells in the hippocampus during radiation therapy of brain tumors leads to neurogenesis impairment and the development of...
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Interplay Between Zika Virus-Induced Autophagy and Neural Stem Cell Fate Determination
The Zika virus (ZIKV) outbreaks and its co-relation with microcephaly have become a global health concern. It is primarily transmitted by a mosquito,...
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Glucocorticoid Receptor Down-Regulation Affects Neural Stem Cell Proliferation and Hippocampal Neurogenesis
Dysregulation of the hypothalamic–pituitary–adrenal axis and abnormalities in the glucocorticoid receptor (GR) have been linked to major depressive...
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Sodium Butyrate Induced Neural Stem/Progenitor Cell Death in an Experimental Model of Japanese Encephalitis
The anti-inflammatory and neuroprotective effects of short chain fatty acid (SCFA) butyrate have been explored in a wide array of neurological...
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SOX5 Attenuates Toxicity in Neural Stem Cells Induced by Sevoflurane Anesthesia via Regulating the PI3K/AKT Pathway
AbstractDifferentiation and self-renewal capacity of neural stem cells are essential for the development and function of brain. Anesthesia exposure...
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Isolation and Enrichment of Defined Neural Cell Populations from Heterogeneous Neural Stem Cell Progeny
The renewable source of neural stem cells (NSCs) with multi-lineage differentiation capability toward neurons, astrocytes, and oligodendrocytes...
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Endogenous Neural Stem Cell–induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives
Ischemic stroke is a very common cerebrovascular accident that occurred in adults and causes higher risk of neural deficits. After ischemic stroke,...
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Hepatocyte growth factor pretreatment boosts functional recovery after spinal cord injury through human iPSC-derived neural stem/progenitor cell transplantation
BackgroundHuman induced pluripotent stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC)-based cell transplantation has emerged as a...
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Autophagy in Embryonic Stem Cells and Neural Stem Cells
AutophagyAutophagy is a conserved cytoprotective catabolic pathway that plays a crucial role in cellular turnover and homeostasis in eukaryotic...
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Generating Human Pluripotent Stem Cell-Derived Neural AssemBloids™ to Model Interneuron Migration and Immune Cell Interactions
Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs) have emerged as an innovative model to study the central...
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Using Human Fetal Neural Stem Cells to Elucidate the Role of the JAK-STAT Cell Signaling Pathway in Oligodendrocyte Differentiation In Vitro
Oligodendrocytes (OL) are the myelinating cells of the central nervous system that mediate nerve conduction. Loss of oligodendrocytes results in...
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Xeno-free induced pluripotent stem cell-derived neural progenitor cells for in vivo applications
BackgroundCurrently, there is no regenerative therapy for patients with neurological and neurodegenerative disorders. Cell-therapies have emerged as...
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Human induced neural stem cells support functional recovery in spinal cord injury models
Spinal cord injury (SCI) is a clinical condition that leads to permanent and/or progressive disabilities of sensory, motor, and autonomic functions....
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Omics Analyses in a Neural Stem Cell Model of Familial Parkinson’s Disease
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting millions of people worldwide. Despite considerable efforts,...
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Stem Cell Factor Sox2 and Brain Tumor Development
The SRY (sex determining region Y)-box2 is also known as Sox2 transcription factor (TF) located at Chromosome 3q26.33. It maintains the...
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Stem Cell Culture and Its Applications
Cells are the structural and functional unit of life. The dynamics of life encompass the continuous interaction of the cells with the environment and...