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Endothelin mediates sex-differences in acclimation to high salt diet in rats
IntroductionCurrent understanding of sodium (Na + ) handling is based on studies done primarily in males. Contrary to the gradual increase in high...
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Very low-calorie ketogenic diet (VLCKD): an antihypertensive nutritional approach
BackgroundObesity is accompanied by hormonal, inflammatory and endothelial alterations. These alterations induce a stimulation of several other...
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The functions of hydrogen sulfide on the urogenital system of both males and females: from inception to the present
Hydrogen sulfide (H 2 S) is known as a chemical gas in nature with both enzymatic and non-enzymatic biosynthesis in different human organs. A couple of...
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The Role of Cerebellum and Basal Ganglia Functional Connectivity in Altered Voluntary Movement Execution in Essential Tremor
Substantial evidence highlights the role of the cerebellum in the pathophysiology of tremor in essential tremor (ET), although its potential...
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A Novel Frameshift Variant of the ELF4 Gene in a Patient with Autoinflammatory Disease: Clinical Features, Transcriptomic Profiling and Functional Studies
We described the diagnosis and treatment of a patient with autoinflammatory disease, named “Deficiency in ELF4 , X-linked (DEX)”. A novel ELF4 variant...
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Extracellular vesicles released by glioma cells are decorated by Annexin A2 allowing for cellular uptake via heparan sulfate
Extracellular vesicles (EVs) play a crucial role in regulating cell behavior by delivering their cargo to target cells. However, the mechanisms...
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Protocols for Plasmodium gametocyte production in vitro: an integrative review and analysis
BackgroundThe production of Plasmodium gametocytes in vitro is a real challenge. Many protocols have been described, but few have resulted in the...
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Chromatin Immunoprecipitation Sequencing (ChIP-Seq) Assay in Food Allergy Research
Chromatin immunoprecipitation (ChIP) analysis followed by genome-wide sequencing represents the most efficient method for studying the complex...
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Very low-calorie ketogenic diet (VLCKD) in the management of hidradenitis suppurativa (Acne Inversa): an effective and safe tool for improvement of the clinical severity of disease. Results of a pilot study
BackgroundHidradenitis suppurativa (HS), an inflammatory-based dermatological condition often associated with obesity, poses significant challenges...
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Multi-omics characterization of a scoring system to quantify hypoxia patterns in patients with head and neck squamous cell carcinoma
BackgroundThe 5-year survival rate of patients with head and neck squamous cell carcinoma (HNSCC) remains < 50%. Hypoxia patterns are a hallmark of...
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Automatic gait events detection with inertial measurement units: healthy subjects and moderate to severe impaired patients
BackgroundRecently, the use of inertial measurement units (IMUs) in quantitative gait analysis has been widely developed in clinical practice....
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Transcriptomics of the Carotid Body
The carotid body (CB) has emerged as a potential therapeutic target for treating sympathetically mediated cardiovascular, respiratory, and metabolic...
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Targeting cholesterol impairs cell invasion of all breast cancer types
BackgroundBreast cancer clinical outcome relies on its intrinsic molecular subtype and mortality is almost exclusively due to metastasis, whose...
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Increased cerebral vascular resistance underlies preserved cerebral blood flow in response to orthostasis in humans on a high-salt diet
Cerebral blood flow autoregulation protects brain tissue from blood pressure variations and maintains cerebral perfusion pressure by changes in...
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Molecular Dynamics Simulation-Based Prediction of Glycosaminoglycan Interactions with Drug Molecules
Glycosaminoglycans (GAGs) are a class of long linear anionic periodic polysaccharides. Their biological activities are very broad including tissue...
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Dopamine and Glutamate Crosstalk Worsen the Seizure Outcome in TLE-HS Patients
Temporal lobe epilepsy (TLE), accompanied by hippocampal sclerosis (HS), is the most common form of drug-resistant epilepsy (DRE). Nearly 20% of the...
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Mucopolysaccharidosis type IIIC in chinese mainland: clinical and molecular characteristics of ten patients and report of six novel variants in the HGSNAT gene
BackgroundMucopolysaccharidosis type IIIC (MPS IIIC; Sanfilippo syndrome C) is a rare lysosomal storage disease caused by mutations in the...
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The significant mechanism and treatments of cell death in heatstroke
With global warming, extreme environmental heat is becoming a social issue of concern, which can cause adverse health results including heatstroke...
