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Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice
A transient ischemic attack (TIA) can cause reversible and delayed impairment of cognition, but the specific mechanisms are still unclear. Annexin a1...
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The Role of Cognitive Reserve in Protecting Cerebellar Volumes of Older Adults with mild Cognitive Impairment
The present study aims to investigate the relationship between cerebellar volumes and cognitive reserve in individuals with Mild Cognitive Impairment...
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Interhemispheric inhibition and gait adaptation associations in people with multiple sclerosis
BackgroundMultiple sclerosis is a neurodegenerative disease that damages the myelin sheath within the central nervous system. Axonal demyelination,...
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Coherence in event-related EEG oscillations in patients with Alzheimer’s disease dementia and amnestic mild cognitive impairment
Objectives Working memory performances are based on brain functional connectivity, so that connectivity may be deranged in individuals with mild...
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The cognitive effect of non-invasive brain stimulation combined with cognitive training in Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis
BackgroundNon-invasive brain stimulation (NIBS) combined with cognitive training (CT) may have shown some prospects on improving cognitive function...
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Targeted cognitive game training enhances cognitive performance in multiple sclerosis patients treated with interferon beta 1-a
BackgroundPrevention of cognitive decline in Multiple Sclerosis (MS) is of major importance. We explored the effect of a 6 months computerized game...
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Excitability of the Nociceptive System in Rats after Blast-Induced Traumatic Brain Injury
In a group of healthy adult male albino rats ( n =6), we measured pain thresholds under conditions of electrocutaneous stimulation of the limbs (in a...
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Ketamine abrogates sensorimotor deficits and cytokine dysregulation in a chronic unpredictable mild stress model of depression
Major depressive disorder (MDD) is a serious mental disorder with influence across the functional systems of the body. The pathogenesis of MDD has...
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Abnormal multisensory integration in relapsing–remitting multiple sclerosis
Temporal Binding Window (TBW) represents a reliable index of efficient multisensory integration process, which allows individuals to infer which...
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Glutamate in Multiple Sclerosis: From Pathophysiology to Treatments
Multiple sclerosis (MS) is an autoimmune disease typified by overt demyelination and inflammation that develop in selected regions of the central...
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Gateway reflexes describe novel neuro-immune communications that establish immune cell gateways at specific vessels
Neuroinflammation is an important biological process induced by complex interactions between immune cells and neuronal cells in the central nervous...
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Transcutaneous auricular vagus nerve stimulation attenuates inflammatory bowel disease in children: a proof-of-concept clinical trial
BackgroundVagus nerve stimulation is an investigational anti-inflammatory therapy targeting the nervous system to modulate immune activity. This...
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Using neural biomarkers to personalize dosing of vagus nerve stimulation
BackgroundVagus nerve stimulation (VNS) is an established therapy for treating a variety of chronic diseases, such as epilepsy, depression, obesity,...
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Models for Assessing Anxiety and Depression in Multiple Sclerosis: from Mouse to Man
Multiple sclerosis (MS) patients often suffer from anxiety disorders and depression. An effective treatment would improve quality of life and would...
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The gateway reflex regulates tissue-specific autoimmune diseases
The dynamic interaction and movement of substances and cells between the central nervous system (CNS) and peripheral organs are meticulously...
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Clinical safety and feasibility of a novel implantable neuroimmune modulation device for the treatment of rheumatoid arthritis: initial results from the randomized, double-blind, sham-controlled RESET-RA study
BackgroundRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes persistent synovitis, bone damage, and progressive joint...
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Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells
BackgroundAlbuterol is the first-line asthma medication used in diverse populations. Although DNA methylation (DNAm) is an epigenetic mechanism...
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Advanced Drug Delivery Approaches Containing Synbiotics
Synbiotics have shown various beneficial effects in inflammatory bowel diseases, irritable bowel syndrome, infectious disorders, and diarrheal...
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Connectivity Alterations in Emotional and Cognitive Networks During a Manic State Induced by Direct Electrical Stimulation
Mania is characterized by affective and cognitive alterations, with heightened external and self-awareness that are opposite to the alteration of...
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Letter K
Kabuki syndrome (Kabuki make-up syndrome, Niikawa-Kuroki Syndrome) is a rare multisystemic disorder characterized by a distinct face, postnatal...