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Methyl β-Cyclodextrin-sperm-mediated gene editing (MBCD-SMGE): a simple and efficient method for targeted mutant mouse production
BackgroundGenerating targeted mutant mice is a crucial technology in biomedical research. This study focuses on optimizing the CRISPR/Cas9 system...
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Lurcher Mouse
Lurcher mutant mouse is a natural model of hereditary cerebellar degeneration which is caused by a mutation in the δ2 glutamate receptor encoding...
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The Rolling Nagoya Mouse
The natural mutant mouse rolling Nagoya is severely ataxic and frequently shows body roll-overs. The phenotype is inherited in an autosomal recessive...
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Long-term inhibition of mutant LRRK2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects
Parkinson’s disease (PD) is characterized by dopaminergic neurodegeneration in nigrostriatal and cortical brain regions associated with pathogenic...
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Moonwalker Mouse
The Moonwalker (Mwk) mouse is a dominant ataxic mouse model of inherited cerebellar ataxia caused by a gain-of-function mutation in the gene encoding...
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Rolling Nagoya Mouse
The natural mutant mouse rolling Nagoya has an uncoordinated gait and frequently displays sideways body rolls. The mutation underlying this autosomal...
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LRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson's disease
Mutations in the leucine-rich repeat kinase 2 gene ( LRRK2 ) are one of the most frequent genetic causes of both familial and sporadic Parkinson’s...
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The Staggerer Mouse: RORα Deficiency Induces Cerebellar Neurodegeneration
The staggerer mutant mouse carries a spontaneous mutation in the ligand-binding domain of the rora gene. RORα is expressed in many tissues and its...
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Dual inhibition of SUMOylation and MEK conquers MYC-expressing KRAS-mutant cancers by accumulating DNA damage
BackgroundKRAS mutations frequently occur in cancers, particularly pancreatic ductal adenocarcinoma, colorectal cancer, and non-small cell lung...
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Phenotypic Analysis of Early Neurogenesis in a Mouse Chimeric Embryo and Stem Cell-Based Neuruloid Model
Analyzing the impact of genetic mutations on early neurogenesis of mammalian embryos in conventional mouse mutant models is laborious and...
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Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation
BackgroundThe identification of novel therapeutic strategies to overcome resistance to the MEK inhibitor trametinib in mutant KRAS lung...
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Lurcher Mouse
Lurcher mutant mice represent one of the frequently used mouse models of the olivocerebellar degenerationOlivocerebellar degeneration. It is caused...
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Disease-Associated Q159X Mutant Prion Protein Is Sufficient to Cause Fatal Degenerative Disease in Mice
PRNP Q160X is one of the five dominantly inheritable nonsense mutations causing familial prion diseases. Till now, it remains unclear how this type...
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Genetic alterations that deregulate RB and PDGFRA signaling pathways drive tumor progression in IDH2-mutant astrocytoma
In IDH -mutant astrocytoma, IDH2 mutation is quite rare and biological mechanisms underlying tumor progression in IDH2 -mutant astrocytoma remain...
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Moonwalker Mouse
The Moonwalker (Mwk) mouse is a model of dominantly inherited cerebellar ataxia. The ataxic phenotype is caused by a gain-of-function mutation in the...
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Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1-Induced Neuronal Cell Death
Although a couple of studies have reported that mutant superoxide dismutase 1 (SOD1), one of the causative genes of familial amyotrophic lateral,...
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Microglia Preserve Visual Function in a Mouse Model of Retinitis Pigmentosa with Rhodopsin-P23H Mutant
Most forms of outer retinal degenerative diseases involve the ectopic accumulation of microglia/macrophages in the subretinal space, including...
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Stalled oligodendrocyte differentiation in IDH-mutant gliomas
BackgroundRoughly 50% of adult gliomas harbor isocitrate dehydrogenase ( IDH ) mutations. According to the 2021 WHO classification guideline, these...
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A Facile Method to Append a Bio-ID Tag to Endogenous Mutant Kras Alleles
KRAS mutations occur in approximately ~50% of colorectal cancers (CRCs) and are associated with poor prognosis and resistance to therapy. While these...
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Robotic Mouse
Gene targeting is a very powerful approach for the generation of clinically relevant mouse models to elucidate the underlying molecular basis of...