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Creation of an Isogenic H/N/KRAS-Less Mouse Embryonic Fibroblast Cell Line Panel Derived from a Size-Sorted Diploid Clone
Cell line panels have proven to be an invaluable tool for investigators researching a range of topics from drug mechanism or drug sensitivity studies...
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Phenotypic Analysis of Early Neurogenesis in a Mouse Chimeric Embryo and Stem Cell-Based Neuruloid Model
Analyzing the impact of genetic mutations on early neurogenesis of mammalian embryos in conventional mouse mutant models is laborious and...
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CRISPR Activation in Mouse Trophoblast Stem Cells
The placenta is a vital organ that regulates nutrient supply to the develo** embryo during gestation. In mice, the placenta is composed of...
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Cell fate determination and Hippo signaling pathway in preimplantation mouse embryo
First cell fate determination plays crucial roles in cell specification during early phases of embryonic development. Three classical concepts have...
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Transcription of MERVL retrotransposons is required for preimplantation embryo development
Zygotic genome activation (ZGA) is a critical postfertilization step that promotes totipotency and allows different cell fates to emerge in the...
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Targeting fibroblast activation protein (FAP): advances in CAR-T cell, antibody, and vaccine in cancer immunotherapy
Fibroblast activation protein (FAP) is a serine protease with dual enzymatic activities overexpressed in cancer-associated fibroblasts (CAFs) in...
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Origin and function of activated fibroblast states during zebrafish heart regeneration
The adult zebrafish heart has a high capacity for regeneration following injury. However, the composition of the regenerative niche has remained...
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Epithelial-mesenchymal transition process during embryo implantation
The epithelial to mesenchymal transition (EMT) in endometrial epithelial and trophectoderm cells is essential for the progression of embryo...
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Exploring the MEN1 dependent modulation of caspase 8 and caspase 3 in human pancreatic and murine embryo fibroblast cells
MEN1 mutation causes pancreatic neuroendocrine neoplasia and benign malignancies of the parathyroid, the adrenal cortex and pituitary gland. The...
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Oviduct as a sensor of embryo quality: deciphering the extracellular vesicle (EV)-mediated embryo-maternal dialogue
AbstractEmbryo-derived extracellular vesicles (EVs) may play a role in mediating the embryo-maternal dialogue at the oviduct, potentially carrying...
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Characteristics of mouse embryonic fibroblasts by cryopreservation period for tissue engineering
ObjectiveFibroblasts are widely used as feeder cells that are co-cultured with stem cells to support embryonic stem cells in tissue engineering....
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Synthesis of Fluorescent C–C Bonded Triazole-Purine Conjugates
A design toward C–C bonded 2,6-bis(1 H -1,2,3-triazol-4-yl)-9 H -purine and 2-piperidinyl-6-(1 H -1,2,3-triazol-4-yl)-9 H -purine derivatives was established...
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Symmetric inheritance of parental histones contributes to safeguarding the fate of mouse embryonic stem cells during differentiation
Parental histones, the carriers of posttranslational modifications, are deposited evenly onto the replicating DNA of sister chromatids in a process...
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Isolation of Mouse Embryonic Neural Stem Cells and Characterization of Neural Stem Markers by Flow Cytometry
Neurogenesis is outlined as a process in which new neurons are generated from neural stem cells (NSCs). This process comprises proliferation and fate...
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Exploring caspase functions in mouse models
Caspases are enzymes with protease activity. Despite being known for more than three decades, caspase investigation still yields surprising and...
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Isolation and Neuronal Reprogramming of Mouse Embryonic Fibroblasts
Forced expression of specific neuronal transcription factors in mouse embryonic fibroblasts (MEFs) can lead to their direct conversion into...
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Mechanisms of Development
Many of the mechanisms underlying neural development are basically similar in vertebrates and invertebrates. Among vertebrates, popular species for...
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Mouse fibroblast growth factor 9 N143T mutation leads to wide chondrogenic condensation of long bones
Long bones of the appendicular skeleton are formed through endochondral ossification. Endochondral bone formation initiates with mesenchymal...
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Therapeutic Prospects of Nitric Oxide as an Anti-teratogen
A physical, chemical or biological agent that causes malformation of the embryo of foetus is referred to as teratogen. Foetal abnormalities have...
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Discovery of novel DprE1 inhibitors via computational bioactivity fingerprints and structure-based virtual screening
Decaprenylphosphoryl-β-D-ribose oxidase (DprE1) plays important roles in the biosynthesis of mycobacterium cell wall. DprE1 inhibitors have shown...
