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State-independent inhibition of the oncogenic Kv10.1 channel by desethylamiodarone, a comparison with amiodarone
Kv10.1 is a voltage-dependent K channel whose ectopic expression is associated with several human cancers. Additionally, Kv10.1 has...
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Comprehensive voxel-wise, tract-based, and network lesion map** reveals unique architectures of right and left visuospatial neglect
Visuospatial neglect is a common, post-stroke cognitive impairment which is widely considered to be a disconnection syndrome. However, the patterns...
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Surgery of joints
Crude forms of musculoskeletal surgery have been performed through history for the treatment of deformity, pain and the horrors of battle. In more...
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Project ECHO for Cancer Care: a Sco** Review of Provider Outcome Evaluations
The Project ECHO model of telementoring has been used for the past 10 years to expand access to specialized cancer care. This sco** review...
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Dorothy Price
Dorothy Price was an American zoologist responsible for identifying, characterizing, and formulating the principles of hormoneHormones negative...
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Learning Outcomes of “GetSMART,” Education for Diagnostics and Targeted Treatment for HER2+ Metastatic Gastric and Colorectal Cancers
The treatment landscape for patients affected by gastric and colorectal cancer (G&CRC) has significantly broadened over the past decade. Molecular...
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Hayling and stroop tests tap dissociable deficits and network-level neural correlates
Although many executive function screens have been developed, it is not yet clear whether these assessments are equally effective in detecting...
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Phytogalactolipids activate humoral immunity against colorectal cancer
BackgroundColorectal cancer (CRC) is the third most lethal cancer in the world, and its incidence is steadily rising. In this study, we investigated...
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Cannabinoid tetrad effects of oral Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in male and female rats: sex, dose-effects and time course evaluations
RationaleThe legalization of medicinal use of Cannabis sativa in most US states and the removal of hemp from the Drug Enforcement Agency (DEA)...
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Inhibition of CD4 + T cells by fanchinoline via miR506-3p/NFATc1 in Sjögren’s syndrome
The hyperproliferation and hyperactivation of CD4 + T cells in salivary gland tissues are hallmarks of Sjögren’s syndrome (SS). Fangchinoline (Fan)...
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The relationship between synaptodendritic neuropathology and HIV-associated neurocognitive disorders is moderated by cognitive reserve
We examined whether cognitive reserve moderated the relationship between neurodegeneration and cognition in 67 postmortem persons with HIV (PWH) who...
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Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting the degradation of TRAIL
BackgroundTetrandrine, a bisbenzylisoquinoline (BBI) alkaloid extracted from Stephania tetrandra (S. Moore), and is widely used in several diseases...
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The promise of automated machine learning for the genetic analysis of complex traits
The genetic analysis of complex traits has been dominated by parametric statistical methods due to their theoretical properties, ease of use,...
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TAAR1 Regulates Purinergic-induced TNF Secretion from Peripheral, But Not CNS-resident, Macrophages
Trace amine-associated receptor 1 (TAAR1) is an established neuroregulatory G protein-coupled receptor with recent studies suggesting additional...
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Lupus Anticoagulant Testing: Taipan Snake Venom Time with Ecarin Time as Confirmatory Test
Testing for lupus anticoagulants (LA) in the presence of therapeutic anticoagulation is largely discouraged because of the risk of false-positive and...
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Lupus Anticoagulant Testing: Dilute Prothrombin Time (dPT)
Lupus anticoagulants (LA) rarely affect routine prothrombin time assays because the high phospholipid (PL) content in thromboplastin reagents tends...
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Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys
Understanding the microglial neuro-immune interactions in the primate brain is vital to develo** therapeutics for cortical injury, such as stroke...
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Undergraduate Students’ Engineering Systems Thinking in Synthetic Biology Design: A Qualitative Descriptive Study
The design of biological systems is a multidisciplinary activity in which biomedical engineers collaborate to build novel biological systems that...
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Morphometric study of encephalic lesions in aborted bovine fetuses naturally infected by two subpopulations of Neospora caninum
Neospora caninum is a major reproductive disease in cattle worldwide. In the Argentinian Humid Pampa, the seroprevalence, incidence of abortions, and...
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Inhibition of the K+ conductance and Cole-Moore shift of the oncogenic Kv10.1 channel by amiodarone
The ectopic overexpression of the voltage-dependent Eag1 (Kv10.1) K + channel is associated with the cancerous phenotype in about 70% of human cancers...
