Abstract
Dorothy Price was an American zoologist responsible for identifying, characterizing, and formulating the principles of hormone negative feedback. During her discovery, Price worked with Carl R. Moore in the Department of Zoology at the University of Chicago. Through a series of early studies, Price and Moore established that sex hormone administration reduced gonadal and accessory sex gland size, but the cause was enigmatic. The key to determining the mechanism leading to this sex-hormone-induced reduction came when Price speculated that there was “reciprocal influence” between the gonads and the anterior pituitary. Studies designed and performed by Price in which she showed that daily implants of pituitary fragments could reverse the effects of gonadal steroid administration provided strong evidence for this proposition and formed the foundation for hormone negative feedback, a central principle in endocrinology. Following these seminal findings, Price went onto receive her PhD at the University of Chicago, joined the faculty there, and continued her major contributions to the field throughout her career.
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Kriegsfeld, L.J. (2022). Dorothy Price. In: Nelson, R.J., Weil, Z.M. (eds) Biographical History of Behavioral Neuroendocrinology . Springer, Cham. https://doi.org/10.1007/978-3-031-12970-4_6
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