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The Mood Stabilizer Lithium Slows Down Synaptic Vesicle Cycling at Glutamatergic Synapses
Lithium is a mood stabilizer broadly used to prevent and treat symptoms of mania and depression in people with bipolar disorder (BD). Little is...
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Mood and behavior regulation: interaction of lithium and dopaminergic system
Lithium is one of the most effect mood-stabilizing drugs prescribed especially for bipolar disorder. Lithium has wide range effects on different...
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Ketogenic Diet and Inflammation : Implications for Mood and Anxiety Disorders
The ketogenic diet, known as a low-carbohydrate, high-protein, and high-fat diet, drastically restrains the major source of energy for the body,...
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Abelson Helper Integration Site 1 haplotypes and peripheral blood expression associates with lithium response and immunomodulation in bipolar patients
RationaleIn bipolar disorder (BD), immunological factors play a role in the pathogenesis and treatment of the illness. Studies showed the potential...
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Circadian Rhythms in Mood Disorders
Altered behavioral rhythms are a fundamental diagnostic feature of mood disorders. Patients report worse subjective sleep and objective measures...
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Doxycycline reversal of amphetamine-induced mania-like behavior is related to adjusting brain monoamine abnormalities and antioxidant effects in primary hippocampal neurons
Mania is associated with disturbed dopaminergic transmission in frontotemporal regions. D-amphetamine (AMPH) causes increased extracellular DA...
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Use of antidepressants and mood stabilizers in persons with first-episode schizophrenia
PurposeAntipsychotics are first-line treatment of schizophrenia. They are often accompanied by adjunctive treatments, such as antidepressant (AD) or...
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Aripiprazole and its adverse effects in the form of impulsive-compulsive behaviors: A systematic review of case reports
Aripiprazole is an efficacious treatment for both the positive and negative symptoms of schizophrenia and is also commonly used as a mood stabilizer....
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Paradoxical changes in mood-related behaviors on continuous social isolation after weaning
Continuous social isolation (SI) from an early developmental stage may have different effects in youth and adulthood. Moreover, SI is reported to...
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Fixed Dose Combination Tablets of Aripiprazole and Divalproex Sodium: a Pilot Pharmacokinetic Study in Human Volunteers
A combination product of aripiprazole (antipsychotic) and divalproex sodium (mood stabilizer) was recently developed to establish their tolerability...
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Efficacy of pharmacotherapies for bulimia nervosa: a systematic review and meta-analysis
ObjectiveThe main purpose was to evaluate the efficacy and tolerability of different medications used to treat bulimia nervosa (BN).
Methods ...
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Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria
The steady flow of lactic acid (LA) from tumor cells to the extracellular space via the monocarboxylate transporter symport system suppresses...
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Ayurveda Intervention in Perimenopausal Syndrome
Menopausal transition or perimenopause is the period characterized by irregularities of menses, lengthy and heavy menses with episodes of amenorrhea,...
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Drug Therapy of Psychosis and Mania
Psychosis and mania are psychiatric disorders wherein there is loss of insight for the affected patients. While the exact pathophysiology behind...
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Effects of the monoamine stabilizer, (-)-OSU6162, on cocaine-induced locomotion and conditioned place preference in mice
Cocaine addiction is a severe mental disorder for which few treatment options are available. The underlying mechanisms include facilitation of...
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Effects of the monoamine stabilizer (-)OSU6162 on cognitive function in alcohol dependence
IntroductionAlcohol dependence (AD) is associated with a dysregulated mesolimbocortical dopamine system—a pathway which is also implicated in both...
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Changes in the Midbrain Neurobiological Responses to Lithium Chloride under Inflammatory Conditions
AbstractEffectiveness of psychotropic drugs can be altered under inflammation however the mechanisms of the possible changes remain unclear. In order...
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Circadian neurogenetics of mood disorders
Mood state alterations are often accompanied by disruptions of daily rhythms of physiology. Circadian rhythms of physiology are controlled by a...
