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Modern Diagnostic Tools for Rapid Detection of Multidrug Resistance
The emergence of multidrug resistance (MDR) presents a serious threat to human health throughout the world. It has become a major obstacle in...
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Non-commercial phenotypic assays for the detection of Mycobacterium tuberculosis drug resistance: a systematic review
Several rapid non-commercial culture-based methods and assays for drug susceptibility testing (DST) of Mycobacterium tuberculosis have emerged over...
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Tuberculosis: current scenario, drug targets, and future prospects
Globally recognized genetic modification with time has supported the emergence of versatile and novel featured organisms in nature, some of which can...
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Pediatric Tuberculosis: Current Evidence for Laboratory Diagnosis
As children develop paucibacillary forms of tuberculosis (TB), bacteriological tests usually are negative. This chapter describes aspects of the...
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Affinity of Mycobacterium tuberculosis strains for M059K microglial cells after migration through A549 alveolar epithelium
Tuberculosis (TB) remains a major threat worldwide while central nervous system TB (CNS-TB) is one of the most severe forms of extrapulmonary TB....
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Drug-Resistant Tuberculosis and HIV
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB are associated with substantially worse outcomes than drug-susceptible...
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Antimycobacterial Drugs
The Mycobacterium tuberculosis complex (MTBC)—including, the M. tuberculosis and seven other closely-related species (like M. bovis)—are the...
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Nomogram to predict multidrug-resistant tuberculosis
BackgroundMultidrug-resistant tuberculosis (MDR-TB) is burgeoning globally, and has been a serious challenge in TB management. Clinically, the...
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Of tuberculosis and non-tuberculous mycobacterial infections – a comparative analysis of epidemiology, diagnosis and treatment
Pulmonary diseases due to mycobacteria cause significant morbidity and mortality to human health. In addition to tuberculosis (TB), caused by Mycobacte...
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The Challenge of Drug-Resistant Tuberculosis: An Update
Tuberculosis (TB) is one of the leading causes of death from a single infectious agent, and millions of people fall sick due to this disease every...
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Assessment of CD27 expression on T-cells as a diagnostic and therapeutic tool for patients with smear-negative pulmonary tuberculosis
BackgroundThere is a global focus on illness diagnosis in smear-negative and latent tuberculosis infectious populations (SN-TB and LTBI). CD27 has...
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Lipocalin 2—not only a biomarker: a study of current literature and systematic findings of ongoing clinical trials
Lipocalin 2 (Lcn2), also known as neutrophil gelatinase–associated lipocalin, is an innate immune protein encoded by the LCN2 gene. In this study,...
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TB Diagnostics: Journey from Smear Microscopy to Whole Genome Sequencing
Tuberculosis is not just a basic clinical and general issue of the whole world. It has attracted worldwide attention of the entire scientific...
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Gastrointestinal and Peritoneal Tuberculosis
Abdominal tuberculosis may affect the gastrointestinal tract, the peritoneum, intra-abdominal lymph nodes and the solid abdominal viscera. This...
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Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
To characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobact...
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Drug-Resistant Tuberculosis
The incidence of drug-resistant tuberculosis (TB), particularly multidrug-resistant TB and extensively drug-resistant TB, is increasing and is a...
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Evaluation of Mycotube, a modified version of Lowenstein–Jensen (LJ) medium, for efficient recovery of Mycobacterium tuberculosis (MTB)
Timely diagnosis of tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is only achieved for ~58% cases. An improved, accurate, time- and...
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General and advanced diagnostic tools to detect Mycobacterium tuberculosis and their drug susceptibility: a review
The global control of tuberculosis remains a great challenge from the standpoint of diagnosis, detection of drug resistance, and treatment, because...