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Machine learning for the micropeptide encoded by LINC02381 regulates ferroptosis through the glucose transporter SLC2A10 in glioblastoma
Glioblastoma (GBM) is the most common primary intracranial tumor in the central nervous system, and resistance to temozolomide is an important reason...
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Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma
BackgroundAlthough, micropeptides encoded by non-coding RNA have been shown to have an important role in a variety of tumors processes, there have...
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Micropeptides: potential treatment strategies for cancer
Some noncoding RNAs (ncRNAs) carry open reading frames (ORFs) that can be translated into micropeptides, although noncoding RNAs (ncRNAs) have been...
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Emerging role of long noncoding RNA-encoded micropeptides in cancer
Increasing evidence has indicated that long noncoding RNAs (lncRNAs) play various important roles in the development of cancers. The widespread...
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Micropeptides: origins, identification, and potential role in metabolism-related diseases
With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode...
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p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy
Long non-coding RNAs (lncRNAs) have been identified as master gene regulators through various mechanisms such as transcription, translation, protein...
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Advances in the understanding of circRNAs that influence viral replication in host cells
Circular RNAs (circRNAs) are non-coding RNAs discovered in recent years, which are produced by back-splicing involving the 3’ and 5’ ends of RNA...
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Beyond traditional translation: ncRNA derived peptides as modulators of tumor behaviors
Within the intricate tapestry of molecular research, noncoding RNAs (ncRNAs) were historically overshadowed by a pervasive presumption of their...
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Aquaporins in Tumor
Recent researches have demonstrated that aquaporins (AQPs), including water-selective channels, aquaglyceroporins and superaquaporins, are generally...
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Exosomal Non-coding RNAs
Cancer remains to be one of the major cause of morbidity and mortality worldwide with breast cancer being the most frequently diagnosed cancer among...
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Exosomal Non-coding RNAs
Cancer remains to be one of the major cause of morbidity and mortality worldwide with breast cancer being the most frequently diagnosed cancer among...
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Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications
Breast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming of energy metabolism is a major...
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Short open reading frames (sORFs) and microproteins: an update on their identification and validation measures
A short open reading frame (sORFs) constitutes ≤ 300 bases, encoding a microprotein or sORF-encoded protein (SEP) which comprises ≤ 100 amino acids....
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Scoring model based on the signature of non-m6A-related neoantigen-coding lncRNAs assists in immune microenvironment analysis and TCR-neoantigen pair selection in gliomas
BackgroundSmall peptides encoded by long non-coding RNAs (lncRNAs) have attracted attention for their various functions. Recent studies indicate that...
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LINC00467: an oncogenic long noncoding RNA
Long non-coding RNAs (lncRNAs) have been found to play essential roles in the cell proliferation, fission and differentiation, involving various...
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Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review
Cells within tissues are subject to various mechanical forces, including hydrostatic pressure, shear stress, compression, and tension. These...
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Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential
Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In cancer cells, metabolic pathway activity varies during...
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The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications
N6-methyladenosine (m6A) is one of the epigenetic modifications of RNA. The addition of this chemical mark to RNA molecules regulates gene expression...
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Microproteins: from behind the scenes to the spotlight
Microproteins, less than 200 amino acids, have been usually regarded as non-functional for a long time. We do not recognize this “dark matter” in the...
