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Comparison of outcome after stereotactic ablative radiotherapy of patients with metachronous lung versus primary lung cancer
BackgroundEarly-stage lung cancer, primarily treated with surgery, often occur in poor surgical candidates (impaired respiratory function, prior...
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Analysis of risk characteristics for metachronous metastasis in different period of nasopharyngeal carcinoma
ObjectiveTo identify the main risk factors for metachronous metastatic nasopharyngeal carcinoma (NPC) in different periods after radiotherapy and...
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Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases
BackgroundColorectal cancer is a highly prevalent and deadly. The most common metastatic site is the liver. We performed a whole exome sequencing...
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Risks and cancer associations of metachronous and synchronous multiple primary cancers: a 25-year retrospective study
BackgroundThe situation of patients develo** multiple primary cancers is becoming more frequent and graver. This study investigated the risks of...
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Secondary Prevention of Gastrointestinal Tumors
Gastrointestinal cancers represent a challenge for public health, especially due to their elevated incidence and poor prognosis. They have a...
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Elucidating the clonal relationship of esophageal second primary tumors in patients with laryngeal squamous cell carcinoma
Laryngeal cancer ranks as the second most prevalent upper airway malignancy, following Lung cancer. Although some progress has been made in managing...
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Stereotactic ablative body radiotherapy with a central high dose using CyberKnife for metastatic lung tumors
BackgroundThe CyberKnife system features a robotically-positioned linear accelerator to deliver real-time image-guided stereotactic ablative body...
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Other Less Prevalent Tumors of the Central Nervous System
The presented tumors in this chapter are somewhat very rare, and their management is still debated due to the scarcity of information about their...
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Discordant DNA mismatch repair protein status between synchronous or metachronous gastrointestinal carcinomas: frequency, patterns, and molecular etiologies
The widespread use of tumor DNA mismatch repair (MMR) protein immunohistochemistry in gastrointestinal tract (GIT) carcinomas has unveiled cases...
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Multifocal organoids reveal clonal associations between synchronous intestinal tumors with pervasive heterogeneous drug responses
Multifocal colorectal cancer (CRC) comprises both clonally independent primary tumors caused by inherited predisposition and clonally related tumors...
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Evaluation of functional outcome of bilateral kidney tumors after sequential surgery
BackgroundThere are limited data concerning patients treated with sequential bilateral kidney surgery. Current guidelines still lack an optimal...
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Risk factors of metachronous brain metastasis in patients with EGFR-mutated advanced non-small cell lung cancer
BackgroundNSCLC patients with EGFR mutation were at a higher incidence of develo** brain metastasis (BM). Patients with BM are associated with high...
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Emerging trends in the coexistence of primary lung Cancer and hematologic malignancy: a comprehensive analysis of clinicopathological features and genetic abnormalities
BackgroundThe incidence of multiple primary cancers (MPC), especially involving primary lung cancer (PLC) and primary hematologic malignancies (PHM),...
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Reconstructing Phylogenetic Relationship in Bladder Cancer: A Methodological Overview
Bladder cancer (BC) expresses itself as a highly heterogeneous disease both at the histological and molecular level, often occurring as synchronous...
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Gene expression profiling for the diagnosis of multiple primary malignant tumors
BackgroundThe incidence of multiple primary malignant tumors (MPMTs) is rising due to the development of screening technologies, significant...
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The co-occurrence of both breast- and differentiated thyroid cancer: incidence, association and clinical implications for daily practice
BackgroundBreast cancer (BC) and differentiated thyroid cancer (TC) are two common cancer types with the highest incidence in women. BC and TC can...
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A case of Ph+ acute lymphoblastic leukemia and EGFR mutant lung adenocarcinoma synchronous overlap: may one TKI drug solve two diseases?
BackgroundPhiladelphia chromosome positive (Ph + ) acute lymphoblastic leukemia (ALL) refers to ALL patients with t(9;22) cytogenetic abnormalities,...
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The frequency and clinical implication of mismatch repair protein deficiency in Chinese patients with ovarian clear cell carcinoma
BackgroundThe aim of the present study was to assess the prevalence of deficient mismatch repair (MMR) in Chinese ovarian clear cell carcinoma (CCC)...
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Clinicomics-guided distant metastasis prediction in breast cancer via artificial intelligence
BackgroundBreast cancer has become the most common malignant tumour worldwide. Distant metastasis is one of the leading causes of breast...
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Impact of Driver Mutations on the Evolution of Isolated Metachronous Lung Metastasis of Pancreatic Ductal adenocarcinoma
BackgroundThe incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing sharply. The survival of patients with metastases is usually about a...