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Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome
Chronic inflammation is currently considered as a molecular basis of metabolic syndrome. Particularly, obesity-induced inflammation in adipose tissue...
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Bone-derived PDGF-BB enhances hippocampal non-specific transcytosis through microglia-endothelial crosstalk in HFD-induced metabolic syndrome
BackgroundIt is well known that high-fat diet (HFD)-induced metabolic syndrome plays a crucial role in cognitive decline and brain-blood barrier...
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Nutrient sensors and their crosstalk
The macronutrients glucose, lipids, and amino acids are the major components that maintain life. The ability of cells to sense and respond to...
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NK cells are never alone: crosstalk and communication in tumour microenvironments
Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour microenvironment (TME) causes insufficient infiltration and poor efficacy...
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Vascular calcification: from the perspective of crosstalk
Vascular calcification (VC) is highly correlated with cardiovascular disease morbidity and mortality, but anti-VC treatment remains an area to be...
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Crosstalk between DNA methylation and hypoxia in acute myeloid leukaemia
BackgroundAcute myeloid leukaemia (AML) is a deadly disease characterised by the uncontrolled proliferation of immature myeloid cells within the bone...
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Bioinformatic Analysis of the Potential Common Pathogenic Mechanisms for Psoriasis and Metabolic Syndrome
The pathogeneses of psoriasis and metabolic syndrome are closely related; however, the underlying biological mechanisms are yet to be clarified. A...
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Stroke and Distal Organ Damage: Exploring Brain-Kidney Crosstalk
Stroke and kidney dysfunction represent significant public health challenges, yet the precise mechanisms connecting these conditions and their severe...
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Crucial Metabolic Networks: Cancer Progression
The study of metabolic networks in cancer cells is essential for understanding the fundamental properties of living systems and how metabolic...
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Iron-Calcium Crosstalk in Neurodegenerative Diseases
Iron and calcium have one thing in common: they are both required for appropriate neural activity. Neuronal calcium impulses drive neurochemical...
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Cancer Drug Resistance and Metabolic Reprogramming
There is a complex and strong association between metabolic reprogramming and the phenomenon of drug resistance in cancer. Cancer cell metabolic...
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FAS-mediated circRNA-miRNA-mRNA Crosstalk Network Regulates Immune Cell Infiltration in Cerebral Infarction
New data are accumulating on the involvement of interaction among circular RNAs (circRNAs), microRNAs (miRNAs/miRs), and messenger RNAs (mRNAs) in...
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Development of a novel testis-on-a-chip that demonstrates reciprocal crosstalk between Sertoli and Leydig cells in testicular tissue
The reciprocal crosstalk between testicular Sertoli and Leydig cells plays a vital role in supporting germ cell development and maintaining...
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Crosstalk between metabolism and cell death in tumorigenesis
It is generally recognized that tumor cells proliferate more rapidly than normal cells. Due to such an abnormally rapid proliferation rate, cancer...
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Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair
The role of extracellular nucleotides as modulators of inflammation and cell stress is well established. One of the main actions of these molecules...
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Colorectal cancer liver metastasis: genomic evolution and crosstalk with the liver microenvironment
Colorectal cancer (CRC) patients frequently develop liver metastases, which are the major cause of cancer-related mortality. The molecular basis and...
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Crosstalk and plasticity driving between cancer-associated fibroblasts and tumor microenvironment: significance of breast cancer metastasis
Cancer-associated fibroblasts (CAFs) are the most abundant stromal cell population in breast tumors. A functionally diverse population of CAFs...
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Acute exposure to polystyrene nanoparticles promotes liver injury by inducing mitochondrial ROS-dependent necroptosis and augmenting macrophage-hepatocyte crosstalk
BackgroundThe global use of plastic materials has undergone rapid expansion, resulting in the substantial generation of degraded and synthetic...
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CTpathway: a CrossTalk-based pathway enrichment analysis method for cancer research
BackgroundPathway enrichment analysis (PEA) is a common method for exploring functions of hundreds of genes and identifying disease-risk pathways....
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Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (mitobiogenesis) and...
