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Genome-Wide Studies of the Comorbidity of Somatic and Mental Diseases
Studies of the genomic architecture of complex phenotypes, which include common somatic and mental diseases, have shown them to be characterized by...
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Prognostic impact of chronic lymphocytic leukemia comorbidity index in a young population: a real-world evidence study of a national gulf region cohort
In chronic lymphocytic leukaemia (CLL), comorbidities assessed by the CLL comorbidity index (CLL-CI) have been associated with outcomes in Western...
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The age-specific comorbidity burden of mild cognitive impairment: a US claims database study
BackgroundIdentifying individuals with mild cognitive impairment (MCI) who are likely to progress to Alzheimer’s disease and related dementia...
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Therapeutics in Metabolic Diseases
Metabolic diseases have important effects on the health and healthcare costs of an individual. It adversely affects various body processes. Metabolic...
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Genetic Structure of Susceptibility to Cardiovascular Continuum Comorbidity
AbstractThe genetic structure of susceptibility to cardiovascular disease continuum (CVDC) comorbidity was analyzed, and the functional importance of...
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Screening for idiopathic pulmonary fibrosis using comorbidity signatures in electronic health records
Idiopathic pulmonary fibrosis (IPF) is a lethal fibrosing interstitial lung disease with a mean survival time of less than 5 years. Nonspecific...
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Untargeted serum metabolic profiling of diabetes mellitus among Parkinson’s disease patients
Type 2 diabetes mellitus (T2DM) is a common comorbidity among Parkinson’s disease (PD) patients. Yet, little is known about dysregulated pathways...
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Bioinformatic Analysis of the Potential Common Pathogenic Mechanisms for Psoriasis and Metabolic Syndrome
The pathogeneses of psoriasis and metabolic syndrome are closely related; however, the underlying biological mechanisms are yet to be clarified. A...
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Evaluation of the EMPAR study population on the basis of metabolic phenotypes of selected pharmacogenes
AbstractThe impact of genetic variability of pharmacogenes as a possible risk factor for adverse drug reactions is elucidated in the EMPAR (Einfluss...
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Dissecting Psychiatric Heterogeneity and Comorbidity with Core Region-Based Machine Learning
Machine learning approaches are increasingly being applied to neuroimaging data from patients with psychiatric disorders to extract brain-based...
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The classification of obesity based on metabolic status redefines the readmission of non-Hodgkin’s lymphoma—an observational study
BackgroundThe relationship between obesity and non-Hodgkin’s lymphoma (NHL) was controversial, which may be due to the crudeness definition of...
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Airway Smooth Muscles Contractions in Metabolic Syndrome
We studied contractile responses of isolated airway smooth muscle segments from rats with metabolic syndrome. Metabolic syndrome was induced in rats...
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Association of Overweight and Obesity with Semen Parameters and Metabolic and Hormonal Status in Young Men
We evaluated possible associations of overweight and obesity with semen parameters, sperm DNA fragmentation (SDF), and different indicators of...
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Comparing plasma and skin imprint metabolic profiles in COVID-19 diagnosis and severity assessment
AbstractAs SARS-CoV-2 continues to produce new variants, the demand for diagnostics and a better understanding of COVID-19 remain key topics in...
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Schizophrenia as metabolic disease. What are the causes?
Schizophrenia (SZ) is a devastating neurodevelopmental disease with an accelerated ageing feature. The criteria of metabolic disease firmly fit with...
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The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis,...
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Systemic Onco-sphere: An Overview from the Host’s Perspective
Cancer is a systemic disease. Although many researchers are trying to eradicate cancer, their efforts are incomplete if the treatment modality does...
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Polypharmacology in Clinical Applications: Metabolic Disease Polypharmacology
Metabolic diseases consisting of different groups of disorders are becoming increasingly prevalent and have a major impact on public health...
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Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing
BackgroundHigher mortality of COVID-19 patients with lung disease is a formidable challenge for the health care system. Genetic association between...
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Metabolic comorbidities and the association with risks of recurrent metastatic disease in breast cancer survivors
BackgroundObesity and other metabolic comorbidities affect over 10% of patients with breast cancer and are closely related with adverse outcomes....