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The mechanosensory neurons of touch and their mechanisms of activation
Our sense of touch emerges from an array of mechanosensory structures residing within the fabric of our skin. These tactile end organ structures...
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Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity
Astrocytes are critical regulators of CNS function and are proposed to be heterogeneous in the develo** brain and spinal cord. Here we identify a...
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The Functional Assessment of LRRK2 in Caenorhabditis elegans Mechanosensory Neurons
The nematode Caenorhabditis elegans (C. elegans) is a powerful model organism to systematically analyze the functions of genes of interest in vivo....
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Co-expression of the neuropeptide proctolin and glutamate in the central nervous system, along mechanosensory neurons and leg muscle in Cupiennius salei
Similar to hair cells in the mammalian cochlear system, mechanosensory neurons in the Central American wandering spider Cupiennius salei are strongly...
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Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS
The cerebrospinal fluid (CSF) is a complex solution that circulates around the CNS, and whose composition changes as a function of an animal’s...
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Exposure to dietary fatty acids oleic and palmitic acid alters structure and mechanotransduction of intestinal cells in vitro
Intestinal cells are continuously exposed to food constituents while adapting to peristaltic movement and fluid shear stress. Oleic acid (OA) and...
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Neural signalling of gut mechanosensation in ingestive and digestive processes
Eating and drinking generate sequential mechanosensory signals along the digestive tract. These signals are communicated to the brain for the timely...
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Shear Stress, Myogenic Response, and Blood Flow Autoregulation
The vascular activity is tonically regulated by two major hemodynamic variations: a force parallel to the blood flow brushing against the endothelial...
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A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice
Coughing is a respiratory behavior that plays a crucial role in protecting the respiratory system. Here we show that the nucleus of the solitary...
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The developmental timing of spinal touch processing alterations predicts behavioral changes in genetic mouse models of autism spectrum disorders
Altered somatosensory reactivity is frequently observed among individuals with autism spectrum disorders (ASDs). Here, we report that although...
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Eccentric muscle contractions: from single muscle fibre to whole muscle mechanics
Eccentric muscle loading encompasses several unique features compared to other types of contractions. These features include increased force, work,...
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Apoptotic contraction drives target cell release by cytotoxic T cells
Cytotoxic T lymphocytes (CTLs) fight intracellular pathogens and cancer by identifying and destroying infected or transformed target cells
1 . To kill,...
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Auditory activity is diverse and widespread throughout the central brain of Drosophila
Sensory pathways are typically studied by starting at receptor neurons and following postsynaptic neurons into the brain. However, this leads to a...
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Molecular Pathways and Animal Models of Defects in Situs
Left–right patterning is among the least well understood of the three axes defining the body plan, and yet it is no less important, with left–right...
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Migraine Type-Dependent Patterns of Brain Activation After Facial and Intranasal Trigeminal Stimulation
In migraine, the trigeminal nerve is intimately involved in the pathophysiology of the disease. We hypothesized that alterations in the sensory...
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Non-pharmacological interventions for vascular health and the role of the endothelium
The most common non-pharmacological intervention for both peripheral and cerebral vascular health is regular physical activity (e.g., exercise...
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Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics
Unraveling the intricate relationship between mechanical factors and brain activity is a pivotal endeavor, yet the underlying mechanistic model of...
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Progress in protecting vestibular hair cells
Vestibular hair cells are mechanosensory receptors that are capable of detecting changes in head position and thereby allow animals to maintain their...
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FGF receptors are required for proper axonal branch targeting in Drosophila
Proper axonal branch growth and targeting are essential for establishing a hard-wired neural circuit. Here, we examined the role of Fibroblast Growth...
