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MDM2: current research status and prospects of tumor treatment
Mousedouble minute 2 (MDM2) is one of the molecules activated by p53 and plays an important role in the regulation of p53. MDM2 is generally believed...
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MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1
Senescence, an intricate and inevitable biological process, characterized by the gradual loss of homeostasis and declining organ functions. The...
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Targeting MDM2 in malignancies is a promising strategy for overcoming resistance to anticancer immunotherapy
MDM2 has been established as a biomarker indicating poor prognosis for individuals undergoing immune checkpoint inhibitor (ICI) treatment for...
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BRD4 promotes gouty arthritis through MDM2-mediated PPARγ degradation and pyroptosis
BackgroundGouty arthritis (GA) is characterized by monosodium urate (MSU) crystal accumulation that instigates NLRP3-mediated pyroptosis; however,...
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Targeting MDM2 for the development of a new cancer therapy: progress and challenges
For much of the past 20 years, MDM2 has been pursued as a cancer therapeutic target. Small molecule inhibitors that block the MDM2-p53...
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S100A6 inhibits MDM2 to suppress breast cancer growth and enhance sensitivity to chemotherapy
BackgroundS100A6 and murine double minute 2 (MDM2) are important cancer-related molecules. A previous study identified an interaction between S100A6...
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TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression
BackgroundAs a novel necrosis manner, ferroptosis has been increasingly reported to play a role in tumor progression and treatment, however, the...
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Licochalcone A alleviates ferroptosis in doxorubicin-induced cardiotoxicity via the PI3K/AKT/MDM2/p53 pathway
Licochalcone A (Lico A), a flavonoid found in licorice, possesses multiple pharmacological activities in modulating oxidative stress, glycemia,...
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Functional role and epithelial to mesenchymal transition of the miR-590-3p/MDM2 axis in hepatocellular carcinoma
BackgroundThere is considerable evidence that microRNAs (miRNAs) regulate several key tumor-associated genes/pathways and may themselves have a dual...
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Protooncogene MDM2 SNP309 (rs2279744) Analysis of Polymorphism in Thyroid Cancer: Pakistani Population
AbstractMDM2 has been found to be a major adverse regulatory factor for p53 and to be associated with increased expression of MDM2 with the...
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p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors
Targeting MDM2-p53 interaction has emerged as a promising antitumor therapeutic strategy. Several MDM2-p53 inhibitors have advanced into clinical...
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Identification of a small-molecule RPL11 mimetic that inhibits tumor growth by targeting MDM2-p53 pathway
BackgroundTargeting ribosome biogenesis to activate p53 has recently emerged as a therapeutic strategy in human cancer. Among various ribosomal...
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GSG2 facilitates the progression of human breast cancer through MDM2-mediated ubiquitination of E2F1
BackgroundBreast cancer (BC) has posed a great threat to world health as the leading cause of cancer death among women. Previous evidence...
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Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression
BackgroundN4-acetylcytidine (ac4C), a widespread modification in human mRNAs that is catalyzed by the N-acetyltransferase 10 (NAT10) enzyme, plays an...
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RAB3D/MDM2/β-catenin/c-MYC axis exacerbates the malignant behaviors of acute myeloid leukemia cells in vitro and in vivo
RAB3D, a small Ras-like GTPase involved in regulating secretory pathway, plays a cancer-promoting role in several solid tumors. However, its role in...
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Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2
Vascular calcification increases morbidity and mortality in patients with cardiovascular and renal diseases. Previously, we reported that histone...
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Functional interaction between S100A1 and MDM2 may modulate p53 signaling in normal and malignant endometrial cells
BackgroundS100A1 expression is deregulated in a variety of human malignancies, but its role in normal and malignant endometrial cells is unclear.
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SETD2 non genomic loss of function in advanced systemic mastocytosis is mediated by an Aurora kinase A/MDM2 axis and can be therapeutically targeted
BackgroundThe SETD2 tumor suppressor gene encodes a histone methyltransferase that safeguards transcription fidelity and genomic integrity via...
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RPL15 promotes hepatocellular carcinoma progression via regulation of RPs-MDM2-p53 signaling pathway
BackroundRPL15 has been found to participate in human tumorigenesis. However, its function and regulatory mechanism in hepatocellular carcinoma (HCC)...
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ABCA6 affects the malignancy of Ewing sarcoma cells via cholesterol-guided inhibition of the IGF1R/AKT/MDM2 axis
PurposeThe relevance of the subfamily A members of ATP-binding cassette (ABCA) transporters as biomarkers of risk and response is emerging in...
