Search
Search Results
-
Determination of Solute Permeability of Microvascular Endothelial Cell Monolayers In Vitro
The microvascular endothelium has a critical role in regulating the delivery of oxygen, nutrients, and water to the surrounding tissues. Under...
-
Human Umbilical Cord Mesenchymal Stem Cells Repair Endothelial Injury and Dysfunction by Regulating NLRP3 to Inhibit Endothelial Cell Pyroptosis in Kawasaki Disease
Vascular endothelial inflammation and endothelial dysfunction are the main causes of endothelial injury in Kawasaki disease (KD). Human umbilical...
-
Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKε/STAT1/NLRP3 Pathway
Atherosclerosis is initiated by vascular endothelial dysfunction, and low-shear stress (LSS) of blood flow is a key factor leading to endothelial...
-
Differential endothelial cell cycle status in postnatal retinal vessels revealed using a novel PIP-FUCCI reporter and zonation analysis
Cell cycle regulation is critical to blood vessel formation and function, but how the endothelial cell cycle integrates with vascular regulation is...
-
Understanding tumour endothelial cell heterogeneity and function from single-cell omics
Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their success is limited owing to insufficient efficacy and...
-
iPSC-Derived Corneal Endothelial Cells
The corneal endothelium is the innermost monolayer of the cornea that maintains corneal transparency and thickness. However, adult human corneal...
-
Circular RNAs: Regulators of endothelial cell dysfunction in atherosclerosis
Endothelial cell (EC) dysfunction is associated with atherosclerosis. Circular RNAs (circRNAs) are covalently closed loops formed by back-splicing,...
-
Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis
A novel rheumatoid arthritis (RA) synovial fluid protein, Syntenin-1, and its receptor, Syndecan-1 (SDC-1), are colocalized on RA synovial tissue...
-
Generation and characterisation of scalable and stable human pluripotent stem cell-derived microvascular-like endothelial cells for cardiac applications
Coronary microvascular disease (CMD) and its progression towards major adverse coronary events pose a significant health challenge. Accurate in vitro...
-
Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy
PurposeOngoing angiogenesis renders the tumor endothelium unresponsive to inflammatory cytokines and interferes with adhesion of leukocytes,...
-
The maturation of iPS cell-derived brain microvascular endothelial cells by inducible-SOX18 expression
BackgroundBrain microvascular endothelial cells (BMECs) play a major role in the blood–brain barrier (BBB), and are critical for establishing an in...
-
Dysregulated endothelial cell markers in systemic lupus erythematosus: a systematic review and meta-analysis
ObjectivesTo perform a systematic literature review and meta-analysis on endothelial cell (EC) markers that are involved and dysregulated in systemic...
-
α7nAChR Activation Combined with Endothelial Progenitor Cell Transplantation Attenuates Lung Injury in Diabetic Rats with Sepsis through the NF-κB Pathway
Chronic diabetes mellitus compromises the vascular system, which causes organ injury, including in the lung. Due to the strong compensatory ability...
-
In vitro model of brain endothelial cell barrier reveals alterations induced by Plasmodium blood stage factors
Cerebral malaria (CM) is a severe neurological condition caused by Plasmodium falciparum . Disruption of the brain-blood barrier (BBB) is a key...
-
Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice
Tissue-resident vascular endothelial stem cells (VESCs), marked by expression of CD157, possess long-term repopulating potential and contribute to...
-
Effect of Cyclic Uniaxial Mechanical Strain on Endothelial Progenitor Cell Differentiation
PurposeEndothelial progenitor cells (EPCs) have been used as an autologous or allogeneic source in multiple tissue engineering applications. EPCs...
-
Evaluation of Glycolysis and Mitochondrial Function in Endothelial Cells Using the Seahorse Analyzer
Endothelial bioenergetics have emerged as a key regulator of endothelial barrier function. Glycolytic parameters have been linked to barrier...
-
The role of PLVAP in endothelial cells
Endothelial cells play a major part in the regulation of vascular permeability and angiogenesis. According to their duty to fit the needs of the...
-
Wnt7a Decreases Brain Endothelial Barrier Function Via β-Catenin Activation
The blood-brain barrier consists of tightly connected endothelial cells protecting the brain’s microenvironment from the periphery. These endothelial...
-
High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro
IntroductionThe humanized anti-α4 integrin blocking antibody natalizumab (NTZ) is an effective treatment for relapsing–remitting multiple sclerosis...
