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The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes
The chicken major histocompatibility complex (MHC, also known as the BF-BL region of the B locus) is notably small and simple with few genes, most of...
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The Discovery of the Major Histocompatibility Complex (MHC): The H-2 in Mice and the HLA in Man
In this chapter I describe how the major histocompatibility system, the H-2 system, was discovered in mice by Peter Gorer in 1935 in London. This...
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Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception
BackgroundGastrointestinal malignancies encompass a diverse group of cancers that pose significant challenges to global health. The major...
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Major Histocompatibility Complex Genes
Antigen binding by B cells occurs directly with the BCR recognizing epitopes on antigens. T cell recognition of antigens cannot occur unless the...
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Major histocompatibility complex genes and locus organization in the Komodo dragon (Varanus komodoensis)
We performed a meta-analysis of the newly assembled Komodo dragon ( Varanus komodoensis ) genome to characterize the major histocompatibility complex...
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Antigen-Presenting Cells and the Major Histocompatibility Complex
In this chapter, we will discuss the principles of antigen presentation. We will learn that the major purpose of antigen-presenting cells, such as...
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Major histocompatibility complex (MHC) associations with diseases in ethnic groups of the Arabian Peninsula
Since the discovery of human leukocyte antigens (HLAs), the function of major histocompatibility complex (MHC) gene families in a wide range of...
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DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-κΒ-IRF1-CIITA pathway
Major histocompatibility complex class II (MHC II) is important for the adaptive immune response because MHC II presents processed antigens to a...
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IMGT/3Dstructure-DB: T-Cell Receptor TR Paratope and Peptide/Major Histocompatibility pMH Contact Sites and Epitope
T-cell receptors (TR), the antigen receptors of T cells, specifically recognize peptides presented by the major histocompatibility (MH) proteins, as...
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HLA Genes: A Hallmark of Functional Genetic Variation and Complex Evolution
The major histocompatibility complex (MHC) with its highly polymorphic HLA genes represents one of the most intensely studied genomic regions in the...
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Genotype imputation methods for whole and complex genomic regions utilizing deep learning technology
The imputation of unmeasured genotypes is essential in human genetic research, particularly in enhancing the power of genome-wide association studies...
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Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes
The association of autoimmune diseases with particular allellic products of the class-II major histocompatibility complex (MHCII) region implicates...
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The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation
The identity of histocompatibility loci, besides human leukocyte antigen ( HLA ), remains elusive. The major histocompatibility complex (MHC) class I MICA...
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Characterization of 100 extended major histocompatibility complex haplotypes in Indonesian cynomolgus macaques
Many medical advancements—including improvements to anti-rejection therapies in transplantation and vaccine development—rely on preclinical studies...
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Depauperate major histocompatibility complex variation in the endangered reticulated flatwoods salamander (Ambystoma bishopi)
Reticulated flatwoods salamander ( Ambystoma bishopi ) populations began decreasing dramatically in the 1900s. Contemporary populations are small,...
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Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
BackgroundThe optic nerve is an important tissue in glaucoma and the unmyelinated nerve head region remains an important site of many early...
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HLA imputation and its application to genetic and molecular fine-map** of the MHC region in autoimmune diseases
Variations of human leukocyte antigen (HLA) genes in the major histocompatibility complex region (MHC) significantly affect the risk of various...
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Individual copy number variation and extensive diversity between major MHC-DAB1 allelic lineages in the European bitterling
Polymorphism of the major histocompatibility complex (MHC), DAB1 gene was characterized for the first time in the European bitterling ( Rhodeus amarus )...
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Nomenclature report on the major histocompatibility complex genes and alleles of the laboratory rat (Rattus norvegicus)
The laboratory rat ( Rattus norvegicus ) has a long tradition as experimental animal in transplantation and autoimmunity research and, hence, there has...
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Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species
The major histocompatibility complex (MHC) is central to the innate and adaptive immune responses of jawed vertebrates. Characteristic of the MHC are...
