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The Discovery of the Major Histocompatibility Complex (MHC): The H-2 in Mice and the HLA in Man

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The Major Histocompatibility Complex (MHC/ HLA) in Medicine

Abstract

In this chapter I describe how the major histocompatibility system, the H-2 system, was discovered in mice by Peter Gorer in 1935 in London. This discovery was possible thanks to the development of “inbred and H-2 recombinant strain of mice” in the Jackson Laboratory in Bar Harbor (Maine, USA). George Snell was the leading scientist in that lab. Years later, in the middle of the 1950s, Jean Dausset in Paris and Jon van Rood in Leiden discovered the homologous system in humans: the HLA. The complexity of such genetic system made impossible for a single lab to analyse and understand the structure of genes and molecules involved. I describe also in this chapter the enormous scientific cooperation that made possible such analysis, namely, “The HLA International Workshops”. These workshops are a unique example of exchange reagents and results at large scale providing with a new scientific nomenclature accepted by different participants. The major histocompatibility system has provided enormous new knowledge in basic genetics and immunology, as well as in medicine with a variety of clinical applications that changed the diagnostics and therapies of a large number of diseases.

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References

  • Albert ED, Baur MP, Mayr WR (eds) (1984) Histocompatibility testing. Springer-Verlag, Berlin

    Google Scholar 

  • Amos DB (1953) The agglutination of mouse leukocytes by iso-immune sera. Br J Exp Path 3:464–470

    Google Scholar 

  • Amos DB, van Rood JJ (eds) (1965) Histocompatibility testing. Munksgaard, Copenhagen

    Google Scholar 

  • Amos DB, Gorer PA, Mikulska BM, Billingham RE, Sparrow EM (1954) An antibody response to skin homographs in mice. Br J Exp Path 35:203–208

    CAS  Google Scholar 

  • Amos DB, Gorer PA, Mikulska ZB (1955) An analysis of an antigenic system in the mouse (the H-2 system). Proc Royal Society 144:369–380

    CAS  Google Scholar 

  • Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC (1987) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329(506–12):96

    Google Scholar 

  • Bodmer W (1977) Histocompatibility testing. Munksgaard, Copenhagen

    Google Scholar 

  • Campbell RD, Trowsdale J (1993) Map of the human MHC. Immunol Today 14(7):349–352

    Article  CAS  PubMed  Google Scholar 

  • Charron D (1996) Genetic diversity of HLA. Functional and medical implication, Vol. 1 and 2. EDK Medical and Scientific International Publisher, Paris

    Google Scholar 

  • Claas FH (1991) Jon van Rood: retired, but not tired of HLA. Hum Immunol 30(4):234–235. https://doi.org/10.1016/0198-8859(91)90001-P

    Article  CAS  PubMed  Google Scholar 

  • Curtoni ES, Mattiuz PL, Tosi RM (1967) Histocompatibility testing. Munksgaard, Copenhagen

    Google Scholar 

  • Dausset J (1954) Leucoagglutinins IV.- Leucoagglutinins and blood transfusions. Vox Sang 4:190–194

    Google Scholar 

  • Dausset J (1958) Iso-leuco-anticorps. Acta Haematol (Basel) 20:156–160

    Article  CAS  Google Scholar 

  • Dausset J (1962) The leukoagglutinins. Transfusion 2:209–215

    Article  CAS  PubMed  Google Scholar 

  • Dausset J (1980) Nobel lecture. The Major Histocompatibility Complex in man past, present, and future concepts. 8 December

    Google Scholar 

  • Dausset J (1984) The birth of MAC. Vox Sang 46(4):235–237

    Article  CAS  PubMed  Google Scholar 

  • Dausset J (1998) Un Clin d’oeil a la vie: La grande aventure HLA. Edition Odile Jacob 75005 Paris. ISBN 2-7381-0570-X

    Google Scholar 

  • Dausset J, Colombani J (eds) (1973) Histocompatibility testing. Munksgaard, Copenhagen

    Google Scholar 

  • David CS (1987) H-2 antigens: genes, molecules, function, NATO ASI series, series a: life sciences, 144. Plenum Press, New York

    Google Scholar 

  • David CS, Shreffler D, Frelinger J (1973) New lymphocyte antigen system (LNA) controlled by the Ir region of the mouse H-2 complex. Proc Natl Acad Sci (PNAS) 70:2509

    Article  CAS  PubMed  Google Scholar 

  • Demant P, Snell G, Hess M, Lemonnier F, Neauport-Sautes C, Kourilsky P (1975) Separate and polymorphic loci controlling two types of polypeptides specificities chains bearing the H-2 private and public specificities. J Immunogenet 2:263–271

    Article  Google Scholar 

  • Dupont B (ed) (1989) Immunobiology of HLA, Vol. 1 and 2. Springer-Verlag, New York

    Google Scholar 

  • Gorer PA (1936a) The detection of a hereditary antigenic difference in the blood of mice by means of human group a serum. J Genet 32:17–32

    Article  Google Scholar 

  • Gorer PA (1936b) The detection of antigenic differences in mouse erythrocytes by the employment of immune sera. Br J Exp Path 17:42–50

    CAS  Google Scholar 

  • Gorer PA (1937a) Further studies on antigenic differences in mouse erythrocytes. Br J Exp Path 18:31–36

    CAS  Google Scholar 

  • Gorer PA (1937b) The genetic and antigenic basis of tumour transplantation. J Path Bac 44:691–697

    Article  Google Scholar 

  • Gorer PA (1938) The antigenic basis of tumour transplantation. J Path Bac 47:231–252

    Article  Google Scholar 

  • Gorer PA (1942) The role of antibodies in immunity to transplanted leukæmia in mice. J Pathol Bacteriol., January 576.809.73:616.155.392. https://doi.org/10.1002/path.1700540107

  • Gorer P, Mikulska ZB (1954) The antibody response to tumour inoculation. Cancer Res 14:651

    CAS  PubMed  Google Scholar 

  • Gorer P, O’Gorman P (1956) The cytotoxic activity of isoantibodies in mice. Transplantation Bull 3:142–143

    Google Scholar 

  • Gorer PA, Lyman S, Snell GD (1948) Studies on the genetic and antigenic basis of tumour transplantation—linkage between a histocompatibility gene and fused in mice. Proc R Soc Ser B-Biol 135(881):499–505

    Article  Google Scholar 

  • Hansen J (2006) Immunobiology of the human MHC. In: Hansen J (ed) Proceedings of the 13th international histocompatibility workshop and conference, Victoria BC 2002. IHWC Press

    Google Scholar 

  • Hansen J, Dupont B (eds) (2006) Immunobiology of the human MHC, vol 1 and 2. International Histocompatibility Working Group Press, Seattle

    Google Scholar 

  • Jager M, Brand A, Claas F (2019) Jon van Rood: the pioneer and his personal view on the early developments of HLA and immunogenetics. Transpl Immunol 52:1–26

    Article  PubMed  Google Scholar 

  • Kissmeyer-Nielsen F (1975) Histocompatibility testing 1975. Munksgaard, Copenhagen

    Google Scholar 

  • Kissmeyer-Nielsen F, Svejgaard A, Hauge M (1968) Genetics of the human HLA-transplantation system. Nature 219:1116–1119

    Article  CAS  PubMed  Google Scholar 

  • Klein J (1986) Seeds of time: fifty years ago Peter a Gorer discovered the H-2 complex. Immunogenetics 24:331–338

    Article  CAS  PubMed  Google Scholar 

  • Klein J (1996) George D. Snell (1903–96) Obituary, 382,402 August. Nature, news and views

    Google Scholar 

  • Klein J, Sato A (2000a) The HLA system: first of two parts. N Engl J Med:702–709

    Google Scholar 

  • Klein J, Sato A (2000b) The HLA system: second of two parts. N Engl J Med:782–786

    Google Scholar 

  • Medawar P (1961) Peter Gorer obituary 1907–1961. The Royal Society Publishing. https://doi.org/10.1098/rsbm.1961.0008

  • Mitchinson A (2003) George Davis Snell 1903–1996, a biographical memory, vol 83. The National Academic Press, Washinton DC

    Google Scholar 

  • Park I, Terasaki P (1970) Origins of the first HLA specificities. Hum Immunol 61:185–189

    Article  Google Scholar 

  • Payne R, Hackel (1961) Inheritance of human leukocyte antigens. Am J Hum Genet 13:306–319

    CAS  PubMed  PubMed Central  Google Scholar 

  • Payne R, Rolfs MR (1958) Fetomaternal leukocyte incompatibility. J Clin Invest 37(12):1756–1763

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Payne R, Tripp M, Weigle J, Bodmer W, Bodmer J (1964) A new leukocyte isoantigen system in man, cold spring Harb. Symp Quant Biol 29:285–295

    Article  CAS  Google Scholar 

  • Payne R, Bodmer WF, Troup GM, Walford RL (1967) Serologic activities and specificities of eleven human leukocyte antisera produced by planned immunization. Transplantation 5(4):597–605

    Article  CAS  PubMed  Google Scholar 

  • Shreffler D, David CS (1975) The H-2 major histocompatibility complex and the I immune response region: genetic variation, function and organization. Adv Immunol 20:125

    Article  CAS  PubMed  Google Scholar 

  • Snell GD (1941) In: Snell GD (ed) The biology of the laboratory mouse. Blakiston, Philadelphia

    Google Scholar 

  • Snell GD (1980) Studies in histocompatibility. Nobel lecture

    Google Scholar 

  • Terasaki PI (1980) Histocompatibility testing, Edited by UCLA Tissue Ty** Laboratory

    Google Scholar 

  • Terasaki P (1990) History of HLA: ten recollections. Published by UCLA Tissue Ty** Laboratory, 1000 Veteran Avenue, Los Angeles, California 90024, ISBN 0-9604606-6-7

    Google Scholar 

  • Terasaki PI, McClelland JD (1964) Microdroplet assay of human serum cytotoxins. Nature 204:998–1000

    Article  CAS  PubMed  Google Scholar 

  • Thorsby E (2009) A short history of HLA. Tissue Antigens 74:101–116

    Article  CAS  PubMed  Google Scholar 

  • Tsuji K, Aizawa M, Sasazuki T (1991) HLA. Oxford University Press, New York. 1992

    Google Scholar 

  • Van Leeuwen A, Eernisse JG, Van Rood JJ (1964) A new leucocyte group with two alleles: leucocyte group five. Vox Sang 9:431–446

    Article  CAS  PubMed  Google Scholar 

  • Van Rood JJ (1962) Leucocyte Grou**: a method and its application. Doctoral thesis, Leiden University

    Google Scholar 

  • Van Rood JJ (1993) HLA and I. Annu Rev Immunol 1:1–28

    Article  Google Scholar 

  • Van Rood JJ, van Leeuwen A (1963) Leucocyte grou**. A method and its application. J Clin Invest 142:1382–1390

    Article  Google Scholar 

  • Van Rood JJ, Eernisse JG, Van Leeuwen A (1958) Leucocyte antibodies in sera from pregnant women. Nature 181(4625):1735–1736

    Article  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Biochemistry, Molecular Biology and Immunology, University of Granada, Granada, Spain

    Federico Garrido

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  1. Federico Garrido
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Garrido, F. (2024). The Discovery of the Major Histocompatibility Complex (MHC): The H-2 in Mice and the HLA in Man. In: The Major Histocompatibility Complex (MHC/ HLA) in Medicine . Springer, Cham. https://doi.org/10.1007/978-3-031-59866-1_1

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