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MSTN is an important myokine for weight-bearing training to attenuate bone loss in ovariectomized rats
Weight-bearing training, as one of resistance exercises, is beneficial to bone health. Myostatin (MSTN) is a negative regulator of skeletal muscle...
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Individual Responses to Creatine Supplementation on Muscular Power is Modulated by Gene Polymorphisms in Military Recruits
PurposeThe aim was to explore five established SNPs (rs1815739, rs1805086, rs2700352, rs28497577, and rs28357094) that are known to modulate skeletal...
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Recent advances in the delivery and applications of nonviral CRISPR/Cas9 gene editing
The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 genome editing system has been a major technological breakthrough that...
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Ostarine blunts the effect of endurance training on submaximal endurance in rats
The purpose of this study is to study the effects of ostarine alone and in combination with endurance training in sexually mature, male Wistar rats....
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Similar sequences but dissimilar biological functions of GDF11 and myostatin
Growth differentiation factor 11 (GDF11) and myostatin (MSTN) are closely related TGFβ family members that are often believed to serve similar...
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Weight-bearing exercise prevents skeletal muscle atrophy in ovariectomized rats
Skeletal muscle atrophy (SMA) is a dominant symptom induced by estrogen deficiency which can lead to severe health problems of postmenopausal women....
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Gene expression of bovine endometrial epithelial cells cultured in matrigel
Glandular epithelial cells (GE) in the endometrium are thought to support the elongation and survival of ruminant embryos by secreting histotrophs....
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Detection of non-targeted transgenes by whole-genome resequencing for gene-do** control
Gene do** has raised concerns in human and equestrian sports and the horseracing industry. There are two possible types of gene do** in the...
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A Genome-Wide Search of New Meat-Productivity Candidate Genes in a North Caucasian Meat and Wool Sheep Breed
AbstractThe search for new genes that affect the growth and development of muscle tissue and are associated with meat productivity traits in sheep is...
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Regulatorische Dysfunktion hemmt die Entwicklung und Anwendung von transgenen Nutztieren in der Landwirtschaft
Seit der Erzeugung der ersten transgenen Nutztiere ist die Technologie zur Erzeugung der Tiere und zur Kontrolle der Transgenexpression ausgereift....
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Insertion/deletion variants within the IGF2BP2 gene identified in reported genome-wide selective sweep analysis reveal a correlation with goat litter size
Insulin-like growth factor 2 mRNA-binding protein 2 ( IGF2BP2 , also called IMP2 ) plays an essential role in the development and maturation of germ...
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Improvement of muscular atrophy by AAV–SaCas9-mediated myostatin gene editing in aged mice
Muscle mass and area usually decrease with age, and this phenomenon is known as sarcopenia. This age-related atrophy correlates with insufficient...
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Gene expressions in cerebral palsy subjects reveal structural and functional changes in the gastrocnemius muscle that are closely associated with passive muscle stiffness
Cerebral palsy (CP) is a non-progressive motor disorder that affects posture and gait due to contracture development. The purpose of this study is to...
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Idiopathic Pulmonary Fibrosis
The unknown aetiology of irreversible fibrotic scarring of lung tissues in Idiopathic Pulmonary Fibrosis (IPF) has resulted in the lack of a gold...
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Genetics and sports performance: the present and future in the identification of talent for sports based on DNA testing
The impact of genetics on physiology and sports performance is one of the most debated research aspects in sports sciences. Nearly 200 genetic...
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DNA-Nukleasen und ihre Verwendung in der Viehzucht
DNA-Nukleasen, darunter Zink-Finger-Nukleasen (ZFN), Transkriptionsaktivator-ähnliche Endonukleasen (TALENS) und Meganukleasen, besitzen lange...
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Expression of hub genes of endothelial cells in glioblastoma-A prognostic model for GBM patients integrating single-cell RNA sequencing and bulk RNA sequencing
BackgroundThis study aimed to use single-cell RNA-seq (scRNA-seq) to discover marker genes in endothelial cells (ECs) and construct a prognostic...
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Sex-specific genetic architecture of blood pressure
The genetic and genomic basis of sex differences in blood pressure (BP) traits remain unstudied at scale. Here, we conducted sex-stratified and...
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Increasing the resting time between drop jumps lessens delayed-onset muscle soreness and limits the extent of prolonged low-frequency force depression in human knee extensor muscles
PurposeUnaccustomed eccentric contractions generally result in a long-lasting contractile impairment, referred to as prolonged low-frequency force...
