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MHCtools 1.5: Analysis of MHC Sequencing Data in R
The genes of the major histocompatibility complex (MHC) play a vital role in the vertebrate immune system and have attracted considerable interest in...
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Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects
The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on the cell surface, which provided the immune system with...
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Neoself Antigens Presented on MHC Class II Molecules in Autoimmune Diseases
Major histocompatibility complex (MHC) class II molecules play a crucial role in immunity by presenting peptide antigens to helper T cells. Immune...
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MHC II immunogenicity shapes the neoepitope landscape in human tumors
Despite advances in predicting physical peptide-major histocompatibility complex I (pMHC I) binding, it remains challenging to identify functionally...
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Antiallergic Effects of Technologically Processed Antibodies to MHC II
The risk of develo** anaphylactic reactions to medications introduces additional difficulties for effective pharmacotherapy. Using a model of...
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Loss of heterozygosity impacts MHC expression on the immune microenvironment in CDK12-mutated prostate cancer
BackgroundIn prostate cancer (PCa), well-established biomarkers such as MSI status, TMB high, and PDL1 expression serve as reliable indicators for...
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Cryptic MHC-E epitope from influenza elicits a potent cytolytic T cell response
The extent to which unconventional forms of antigen presentation drive T cell immunity is unknown. By convention, CD8 T cells recognize viral...
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LATS1/2 loss promote tumor immune evasion in endometrial cancer through downregulating MHC-I expression
BackgroundLATS1/2 are frequently mutated and down-regulated in endometrial cancer (EC), but the contributions of LATS1/2 in EC progression remains...
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How to Predict Binding Specificity and Ligands for New MHC-II Alleles with MixMHC2pred
MHC-II molecules are key mediators of antigen presentation in vertebrate species and bind to their ligands with high specificity. The very high...
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Modulation of MHC and MHC-Like Molecules by Varicella Zoster Virus
Varicella zoster virus (VZV) is a medically important human herpesvirus that has co-evolved with the human host to become a highly successful and...
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Tumor-associated macrophage-derived exosomes LINC01592 induce the immune escape of esophageal cancer by decreasing MHC-I surface expression
BackgroundTAMs (tumor-associated macrophages) infiltration promotes the progression of esophageal cancer (EC). However, the underlying mechanisms...
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TIMP-1 is an activator of MHC-I expression in myeloid dendritic cells with implications for tumor immunogenicity
Immune checkpoint therapies (ICT) for advanced solid tumors mark a new milestone in cancer therapy. Yet their efficacy is often limited by poor...
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Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration
BackgroundRecent studies have discovered an emerging role of IL11 in various colitis-associated cancers, suggesting that IL11 mainly promotes tumor...
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Targeting PCSK9 to upregulate MHC-II on the surface of tumor cells in tumor immunotherapy
BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9), the last member of the proprotein convertase family, functions as a classic...
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Designing High Binding Affinity Peptides for MHC Class I Using MAM: An In Silico Approach
The availability of extensive MHC-peptide binding data has boosted machine learning-based approaches for predicting binding affinity and identifying...
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Blockade of histamine receptor H1 augments immune checkpoint therapy by enhancing MHC-I expression in pancreatic cancer cells
BackgroundAlthough immune checkpoint blockade (ICB) therapy has proven to be extremely effective at managing certain cancers, its efficacy in...
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The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes
The chicken major histocompatibility complex (MHC, also known as the BF-BL region of the B locus) is notably small and simple with few genes, most of...
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Clinical, Immunological, and Genetic Findings in Iranian Patients with MHC-II Deficiency: Confirmation of c.162delG RFXANK Founder Mutation in the Iranian Population
PurposeMajor histocompatibility complex class II (MHC-II) deficiency is a rare inborn error of immunity (IEI). Impaired antigen presentation to...
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MHC class I links with severe pathogenicity in C57BL/6N mice infected with SARS-CoV-2/BMA8
BackgroundThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes non-symptomatic infection, mild influenza-like symptoms to...
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Patterns of evolution in MHC class II DQA and DQB exon 2 genes of Alpine mountain hares, Lepus timidus varronis, and sympatric and parapatric brown hares, L. europaeus, from Switzerland
In natural populations, hybridization is known to occur between a wide range of species. However, its evolutionary significance is less clear. Genes...
