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Sulfonamide derivatives of cis-imidazolines as potent p53-MDM2/MDMX protein-protein interaction inhibitors
p53-MDM2/MDMX interaction inhibitors represent the prospective agents for targeted anticancer therapy in tumors expressing wild-type p53 protein....
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First in class dual MDM2/MDMX inhibitor ALRN-6924 enhances antitumor efficacy of chemotherapy in TP53 wild-type hormone receptor-positive breast cancer models
BackgroundMDM2/MDMX proteins are frequently elevated in hormone receptor-positive (ER+) breast cancer. We sought to determine the antitumor efficacy...
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Translating p53-based therapies for cancer into the clinic
Inactivation of the most important tumour suppressor gene TP53 occurs in most, if not all, human cancers. Loss of functional wild-type p53 is...
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The DNA damage sensor ATM kinase interacts with the p53 mRNA and guides the DNA damage response pathway
BackgroundThe ATM kinase constitutes a master regulatory hub of DNA damage and activates the p53 response pathway by phosphorylating the MDM2...
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Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells
IntroductionMany human breast cancers overexpress the E3 ubiquitin ligase MDM2 and its homolog MDMX. Expression of MDM2 and MDMX occurs in estrogen...
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Applications of Molecular Biology and Biomedical Advances in Ocular Oncology
Retinoblastoma, one of the first cancers for which a genetic basis has been explained, has been the prototype of genetic cancers. In addition to the...
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Tumor Models of Retinoblastoma: In Vivo, Ex Vivo, and In Vitro Models
In the initial simplistic understanding, childhood retinal cancer retinoblastoma is due to the defect in the retinoblastoma gene. However, the deep...
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MDM2: current research status and prospects of tumor treatment
Mousedouble minute 2 (MDM2) is one of the molecules activated by p53 and plays an important role in the regulation of p53. MDM2 is generally believed...
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Therapeutic Approaches and Models in Retinoblastoma
In cancer research, animal models constitute an essential aspect of preclinical investigations. In various human malignancies, such as ovarian,...
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Tumor Models of Retinoblastoma: In Vivo, Ex Vivo, and In Vitro Models
In the initial simplistic understanding, childhood retinal cancer retinoblastoma is due to the defect in the retinoblastoma gene. However, the deep...
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Targeted therapy using nanocomposite delivery systems in cancer treatment: highlighting miR34a regulation for clinical applications
The clinical application of microRNAs in modern therapeutics holds great promise to uncover molecular limitations and conquer the unbeatable castle...
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p53 regulation by ubiquitin and ubiquitin-like modifications
The tumor suppressor p53 plays a central role in stress responses and tumor suppression. The increasingly complex p53 network is controlled by...
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Targeting GNAQ/11 through PKC inhibition in uveal melanoma
Uveal melanoma is a rare malignancy affecting 5.1 patients/million per year with definitive treatment options of enucleation or radiation therapy to...
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Genetics in ophthalmology: molecular blueprints of retinoblastoma
This review presents current knowledge on the molecular biology of retinoblastoma (RB). Retinoblastoma is an intraocular tumor with hereditary and...
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The therapeutic potential of targeting regulated non-apoptotic cell death
Cell death is critical for the development and homeostasis of almost all multicellular organisms. Moreover, its dysregulation leads to diverse...
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Therapeutic Approaches and Models in Retinoblastoma
In cancer research, animal models constitute an essential aspect of preclinical investigations. In various human malignancies, such as ovarian,...
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Post-translational modifications on the retinoblastoma protein
The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour...
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A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish
BackgroundUbiquitin-related rare diseases are generally characterized by developmental delays and mental retardation, but the exact incidence or...
