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Linkage disequilibrium under polysomic inheritance
Linkage disequilibrium (LD) is the non-random association of alleles at different loci. Squared LD coefficients r 2 (for phased genotypes) and
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Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies
Linkage disequilibrium (LD) is the correlation among nearby genetic variants. In genetic association studies, LD is often modeled using large...
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Estimation of cell-free fetal DNA fraction from maternal plasma based on linkage disequilibrium information
Cell-free fetal DNA fraction (FF) in maternal plasma is a key parameter affecting the performance of noninvasive prenatal testing (NIPT). Accurate...
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Scalable bias-corrected linkage disequilibrium estimation under genotype uncertainty
Linkage disequilibrium (LD) estimates are often calculated genome-wide for use in many tasks, such as SNP pruning and LD decay estimation. However,...
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Transmission disequilibrium analysis of whole genome data in childhood-onset systemic lupus erythematosus
Childhood-onset systemic lupus erythematosus (cSLE) patients are unique, with hallmarks of Mendelian disorders (early-onset and severe disease) and...
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The first linkage map for Australo-Papuan Treefrogs (family: Pelodryadidae) reveals the sex-determination system of the Green-eyed Treefrog (Litoria serrata)
Amphibians represent a useful taxon to study the evolution of sex determination because of their highly variable sex-determination systems. However,...
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A linkage disequilibrium-based statistical test for Genome-Wide Epistatic Selection Scans in structured populations
The quest for signatures of selection using single nucleotide polymorphism (SNP) data has proven efficient to uncover genes involved in conserved...
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Evaluating the Genetic Correlations Between Left-Handedness and Mental Disorder Using Linkage Disequilibrium Score Regression and Transcriptome-Wide Association Study
Handedness is an elusive human behavioral phenotypes and the genetic basis of it remains unclear until now. The aim of this study is to evaluate the...
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Noninvasive fetal genoty** of single nucleotide variants and linkage analysis for prenatal diagnosis of monogenic disorders
BackgroundHigh-cost, time-consuming and complex processes of several current approaches limit the use of noninvasive prenatal diagnosis (NIPD) for...
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Current Views on Chr10q26 Contribution to Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is the leading cause of blindness in the global aging population. Familial aggregation and genome-wide...
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25(OH)Vitamin D and autism spectrum disorder: genetic overlap and causality
ObjectiveTo identify whether there exists a genetic correlation and causal relationship between 25(OH)D and autism spectrum disorder (ASD).
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Temporal and genomic analysis of additive genetic variance in breeding programmes
Genetic variance is a central parameter in quantitative genetics and breeding. Assessing changes in genetic variance over time as well as the genome...
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Long Non-coding RNA Genes Polymorphisms H19 (rs2251375) and MALAT1 (rs3200401) Association with Rheumatoid Arthritis and Their Correlation with Disease Activity in a Cohort of Egyptian Patients: A Pilot Study
Rheumatoid arthritis (RA) is a chronic, progressive, inflammatory, autoimmune disease that could be disabling throughout its course. It affects...
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In-silico mining to glean SNPs of pharmaco-clinical importance: an investigation with reference to the Indian populated SNPs
Drugs pharmacology is defined by pharmacokinetics and pharmacodynamics and both of them are affected by genetic variability. Genetic variability...
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Next-generation data filtering in the genomics era
Genomic data are ubiquitous across disciplines, from agriculture to biodiversity, ecology, evolution and human health. However, these datasets often...
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Poor statistical power in population-based association study of gene interaction
BackgroundStatistical epistasis, or “gene–gene interaction” in genetic association studies, means the nonadditive effects between the polymorphic...
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Analysis of Molecular Genetic Variants of Lgals4 in Esophageal Cancer: A Preliminary Report
Esophageal cancer is the eighth most common cancer worldwide and fourth most common in develo** countries. Altered glycosylation pattern of cell...
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The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals
Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the...
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Associations of Polymorphisms in Leptin and Leptin Receptor Genes with Meat Quality in Pigs of the Ukrainian Large White Breed
AbstractThe associations of SNP in leptin gene ( LEP g.2845A>T, LEP g.3996T>C, LEP g.3469T>C) and leptin receptor gene ( LEPR c.232A>T, LEPR ...
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Heterogeneity in the extent of linkage disequilibrium among exonic, intronic, non-coding RNA and intergenic chromosome regions
Whole-genome sequence data enable construction of high-resolution linkage disequilibrium (LD) maps revealing the LD structure of functional elements...
